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ENTRY	nt06273
Name	Glioma
Category	Disease view; Cancer
Pathway	hsa05214 Glioma
Disease	H00042 Glioma
Display	drug-target relation   disease type

ERK signaling                       D3  |   D1,D2  |         N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1                       D3  |   D1,D2  |         N00513        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1                       D3  |   D1,D2  |     N00006        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK                       D3  |   D1,D2  |     N00041        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK                       D3  |   D1,D2  |     N00015    PDGF → PDGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                       D3  |   D1,D2  |     N00016    PDGF* → PDGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                       D3  |   D1,D2  |     N00018        PDGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK   PI3K signaling N00033    EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD N00514        EGFR* → PI3K → PIP3 → AKT ⊣ BAD N00035        EGFR* → PI3K → PIP3 → AKT → MTOR N00042        EGFR* → PI3K → PIP3 → AKT → MTOR → S6K N00039    PDGF → PDGFR → PI3K → PIP3 → AKT → MTOR → S6K N00040        PDGFR* → PI3K → PIP3 → AKT → MTOR N00220            PTEN ⊣ PIP3 → AKT N00051            PTEN* ⌿ PIP3 → AKT N00052            PTEN* ⌿ PIP3 → AKT   Calcium signaling N00026    EGF → EGFR → PLCG → IP3 → Ca2+ → CALM = CAMK N00027        EGFR* → PLCG → IP3 → Ca2+ → CALM = CAMK N00028    PDGF → PDGFR → PLCG → IP3 → Ca2+ → CALM = CAMK N00029        PDGFR* → PLCG → IP3 → Ca2+ → CALM = CAMK   Cell cycle N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00067    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00068        MDM2* ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00069                CDKN2A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00071                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00072                    (CCND+CDK4*) → RB1 ⌿ E2F N00074                        RB1* ⌿ E2F   Transcription N00115    TP53* ⌿ (CDKN1A,GADD45,BAX..

		Drug name
D1	D10024	Selumetinib sulfate (JAN/USAN)
D2	D11675	Mirdametinib (USAN)
D3	D12291	Tovorafenib (USAN/INN)