ERK signaling |
| | | | | | | | | | | | | | | | | | D7 | |
N00001 |
![](/tmp/network_17220457532013247/1_N00001_ds.png) |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | D1,D2,D3,D4,D5,D6 | | | | | | | | | | | | | |
N00002 |
![](/tmp/network_17220457532013247/2_N00002_ds.png) |
| | BCR-ABL | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
PI3K signaling |
N00033 |
![](/tmp/network_17220457532013247/4_N00033_ds.png) |
EGF | → | EGFR | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
| | D1,D2,D3,D4,D5,D6 | | | | | | | | | | | |
N00048 |
![](/tmp/network_17220457532013247/5_N00048_ds.png) |
BCR-ABL | → | (CRKL+CBL+CRK) | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
TGFB signaling |
N00063 |
![](/tmp/network_17220457532013247/7_N00063_ds.png) |
TGFB | → | (TGFBR2+TGFBR1) | → | (SMAD2,SMAD3) | = | SMAD4 |
N00106 |
![](/tmp/network_17220457532013247/8_N00106_ds.png) |
| | AML1-EVI1 | ⊣ | SMAD3 | = | SMAD4 |
N00107 |
![](/tmp/network_17220457532013247/9_N00107_ds.png) |
| | EVI1* | ⊣ | SMAD3 | = | SMAD4 |
JAK-STAT signaling |
N00053 |
![](/tmp/network_17220457532013247/11_N00053_ds.png) |
Cytokine | → | Receptor | → | JAK | → | STAT | ⇒ | PIM1 |
| | | | | | D1,D2,D3,D4,D5,D6 | | | | | |
N00055 |
![](/tmp/network_17220457532013247/12_N00055_ds.png) |
| | | | BCR-ABL | → | STAT5 | ⇒ | BCL2L1 |
Cell cycle |
| | | | | | | | | | D7 | | | | | |
N00066 |
![](/tmp/network_17220457532013247/14_N00066_ds.png) |
CDKN2A | ⊣ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
| | | | | | | | | | D7 | | | | | |
N00067 |
![](/tmp/network_17220457532013247/15_N00067_ds.png) |
CDKN2A* | ⌿ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
| | | | | | | | | | D7 | | | | | |
N00070 |
![](/tmp/network_17220457532013247/16_N00070_ds.png) |
| | | | | | CDKN2A* | ⌿ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00074 |
![](/tmp/network_17220457532013247/17_N00074_ds.png) |
| | | | | | | | | | RB1* | ⌿ | E2F |
Transcription |
N00115 |
![](/tmp/network_17220457532013247/19_N00115_ds.png) |
TP53* | ⌿ | (CDKN1A,GADD45,BAX.. |
|