KEGG    Network variation - NLR signaling
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ENTRYnt06521
NameNLR signaling
CategoryPathway view; Immune system
Pathwayhsa04621 NOD-like receptor signaling pathway
Display drug-target relation   disease type
N00940        (NOD1,NOD2)RIPK2IKKNFKBIANFKB
    IBD1     NOD2*
    Blau syndrome     NOD2*
N00941    Shigella       (IpaH9.8+TNIP1)IKBKG
N01112    SopE/E2CDC42NOD1RIPK2IKKNFKBIANFKB
N01567        (NLRP1+PYCARD)CASP1(IL1B,IL18)
    NAIAD/VAMAS1     NLRP1*
N00742        (NLRP3+PYCARD)CASP1(IL1B,IL18,IL33)
    MWS/CINCA/FCAS1/DFNA34     NLRP3*
N00743    IAV   NS1(NLRP3+PYCARD)
N00864    Yersinia   YopK(NLRP3+PYCARD)
N00933    Escherichia   NleA(NLRP3+PYCARD)
N00948    Shigella IpaH7.8GLMN(NLRP3+PYCARD)CASP1IL1B
N01127      SopERAC1CASP1(IL1B,IL18)
N01126        SipBCASP1(IL1B,IL18)
N00863    Yersinia     YopMCASP1
N01568      (CARD8,GPSM3,IRGM,..(NLRP3+PYCARD)
    IBD30   CARD8*
    IBD19   IRGM*
N01569        (NLRP12+PYCARD)CASP1(IL1B,IL18)
    FCAS2     NALP12*
N00867        (NLRC4+PYCARD)CASP1(IL1B,IL18)
    FCAS4/AIFEC     NLRC4*
N00865    Yersinia   YopK(NLRC4+PYCARD)
N00949    Shigella IpaBK+(NLRC4+PYCARD)CASP1IL1B
N00868        (MEFV+PYCARD)CASP1(IL1B,IL18)
    FMF/AFND     MEFV*
N01570      PSTPIP1MEFV
    PAPA   PSTPIP1*
N00866    Yersinia YopM(PKN1,PKN2)(MEFV+PYCARD)
N00934    LPSCASP4/5(NLRP3+PYCARD+CASP..(IL1B,IL18)
N00935    Escherichia NleFCASP4
N00515      OAS2-5ARNASEL
N00273    HCV NS5AOAS
N00574    HSV US11OAS
N00724    IAV NS1OAS

Disease nameDisease category
IBD1H01227Inflammatory bowel disease (IBD)Immune system disease
Blau syndromeH00285Blau syndromeImmune system disease
ShigellaH00299ShigellosisBacterial infectious disease
SalmonellaH00113SalmonellosisBacterial infectious disease
NAIAD/VAMAS1H02588NLRP1-associated autoinflammation with arthritis and dyskeratosisImmune system disease
H01372VitiligoSkin disease
MWS/CINCA/FCAS1/DFNA34H02555Muckle-Wells syndromeImmune system disease
H02556CINCA syndromeImmune system disease
H02159Familial cold autoinflammatory syndromeImmune system disease
H00604Deafness, autosomal dominantNervous system disease
IAVH00398InfluenzaViral infectious disease
YersiniaH00297PlagueBacterial infectious disease
H00298YersiniosisBacterial infectious disease
EscherichiaH00277Enterohemorrhagic Escherichia coli (EHEC) infectionBacterial infectious disease
H00278Enteropathogenic Escherichia coli (EPEC) infectionBacterial infectious disease
IBD30H01227Inflammatory bowel disease (IBD)Immune system disease
IBD19H01227Inflammatory bowel disease (IBD)Immune system disease
FCAS2H02159Familial cold autoinflammatory syndromeImmune system disease
FCAS4/AIFECH02159Familial cold autoinflammatory syndromeImmune system disease
H01748NLRC4 inflammasomopathyImmune system disease
FMF/AFNDH00288Familial Mediterranean feverImmune system disease
H02590Acute febrile neutrophilic dermatosisImmune system disease
PAPAH00287Pyogenic sterile arthritis, pyoderma gangrenosum, and acne syndromeImmune system disease
HCVH00048Hepatocellular carcinomaCancer
HSVH00365Herpes simplex virus infectionViral infectious disease