KEGG   PATHWAY: anu04070
Entry
anu04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Arvicanthis niloticus (African grass rat)
Class
Environmental Information Processing; Signal transduction
Pathway map
anu04070  Phosphatidylinositol signaling system
anu04070

Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117693287  Ip6k1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
117693294  Ip6k2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
117693356  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
117693421  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117693423  Sacm1l; phosphatidylinositol-3-phosphatase SAC1 [KO:K21797] [EC:3.1.3.-]
117694437  Ocrl; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
117694711  Mtm1; myotubularin isoform X2 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
117695239  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
117695366  Mtmr1; phosphatidylinositol-3-phosphate phosphatase MTMR1 isoform X3 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
117697279  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117702642  Cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
117702697  Ppip5k1; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1 [KO:K13024] [EC:2.7.4.24]
117703017  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8 [KO:K05858] [EC:3.1.4.11]
117703032  Dgkz; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
117703351  Plcb1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
117703352  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
117703529  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
117703949  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117704993  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
117705062  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3 [KO:K05857] [EC:3.1.4.11]
117705197  Pip4p1; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
117705385  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
117706125  Dgkh; diacylglycerol kinase eta isoform X2 [KO:K00901] [EC:2.7.1.107]
117706191  Mtmr6; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117706285  Inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
117706649  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117706658  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
117706875  Pi4kb; phosphatidylinositol 4-kinase beta isoform X1 [KO:K19801] [EC:2.7.1.67]
117707520  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
117708401  Inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X4 [KO:K01099] [EC:3.1.3.36]
117708562  Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
117708613  Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
117708961  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117708986  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117709948  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117710078  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
117710098  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2 [KO:K05857] [EC:3.1.4.11]
117710340  Pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
117710586  Mtmr4; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 isoform X2 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117710637  Dgke; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
117711510  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
117711522  Inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1 [KO:K20278] [EC:3.1.3.36]
117712005  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
117712487  Mtmr3; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117712545  Dgkq; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
117713013  Inpp5f; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
117713135  Pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
117713333  Calml3; calmodulin-like protein 3 [KO:K02183]
117713451  Ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
117713892  Calml5; calmodulin-like protein 5 [KO:K02183]
117713980  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
117714720  Itpr1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 [KO:K04958]
117714743  Itpr2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 [KO:K04959]
117714868  Mtmr14; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
117715270  Pik3c2g; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X4 [KO:K00923] [EC:2.7.1.154]
117715353  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
117715712  Inpp5a; inositol polyphosphate-5-phosphatase A isoform X2 [KO:K01106] [EC:3.1.3.56]
117716200  Pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
117716931  Calm2; calmodulin-2 [KO:K02183]
117717031  Dgkb; diacylglycerol kinase beta isoform X3 [KO:K00901] [EC:2.7.1.107]
117717067  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117717954  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
117717963  Pi4ka; phosphatidylinositol 4-kinase alpha isoform X2 [KO:K00888] [EC:2.7.1.67]
117718161  Dgkg; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
117718299  Synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
117719121  Impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
117719822  Impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
117720071  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
117720856  Dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
117721474  Itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
117721614  Mtmr7; phosphatidylinositol-3-phosphate phosphatase MTMR7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117721973  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117722225  Inpp4a; inositol polyphosphate-4-phosphatase type I A isoform X4 [KO:K01109] [EC:3.1.3.66]
117722248  Ppip5k2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2 [KO:K13024] [EC:2.7.4.24]
117722524  Dgkd; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
117722787  Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X2 [KO:K03084] [EC:3.1.3.86]
117723009  Inpp4b; inositol polyphosphate 4-phosphatase type II isoform X1 [KO:K01109] [EC:3.1.3.66]
117723064  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117723761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
117724336  Itpr3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X1 [KO:K04960]
117724426  Ipmk; inositol polyphosphate multikinase isoform X1 [KO:K00915] [EC:2.7.1.140 2.7.1.151]
117724571  Ip6k3; inositol hexakisphosphate kinase 3 [KO:K07756] [EC:2.7.4.21]
143435789  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
143436294  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
143436383  Dgka; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
143436852  Itpk1; inositol-tetrakisphosphate 1-kinase isoform X1 [KO:K00913] [EC:2.7.1.159 2.7.1.134]
143436876  Calm1; calmodulin-1 [KO:K02183]
143438514  Pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
143438567  Bpnt2; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase [KO:K15759] [EC:3.1.3.7]
143439388  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
143439678  Mtmr2; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
143439793  Cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
143440072  Synj2; synaptojanin-2 isoform X1 [KO:K20279] [EC:3.1.3.36]
143440491  Calm3; calmodulin-3 [KO:K02183]
143440904  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
anu04020  Calcium signaling pathway
anu04144  Endocytosis
anu04151  PI3K-Akt signaling pathway
anu04510  Focal adhesion
KO pathway
ko04070   

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