KEGG   PATHWAY: anu04020
Entry
anu04020                    Pathway                                
Name
Calcium signaling pathway - Arvicanthis niloticus (African grass rat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
anu04020  Calcium signaling pathway
anu04020

Other DBs
GO: 0019722
Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117693356  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
117693487  Mst1; hepatocyte growth factor-like protein [KO:K23441]
117693702  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
117694485  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
117694487  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
117694519  Grm5; metabotropic glutamate receptor 5 [KO:K04604]
117694535  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
117694574  Htr2c; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
117694663  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
117694706  Fgf16; fibroblast growth factor 16 [KO:K04358]
117694813  Grpr; gastrin-releasing peptide receptor [KO:K04169]
117695345  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
117695364  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
117695376  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
117695387  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
117695519  Fgf19; fibroblast growth factor 19 [KO:K22603]
117696107  Gna15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
117696155  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
117696350  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
117696420  Avpr1a; vasopressin V1a receptor [KO:K04226]
117696425  Fgf22; fibroblast growth factor 22 [KO:K04358]
117696450  Orai3; protein orai-3 [KO:K16058]
117696453  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
117696458  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
117696517  Tbxa2r; thromboxane A2 receptor [KO:K04264]
117696768  Fgf3; fibroblast growth factor 3 [KO:K04358]
117696945  Bdkrb2; B2 bradykinin receptor [KO:K03916]
117697008  Fgf4; fibroblast growth factor 4 [KO:K04358]
117697141  Slc8a3; sodium/calcium exchanger 3 [KO:K05849]
117697373  Bdkrb1; B1 bradykinin receptor [KO:K03915]
117697522  Calm1; calmodulin-1 [KO:K02183]
117697636  P2rx4; P2X purinoceptor 4 [KO:K05218]
117697644  Orai2; protein orai-2 [KO:K16057]
117697649  P2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
117697669  Orai1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
117697779  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117697839  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
117697847  Fgf21; fibroblast growth factor 21 [KO:K22429]
117697928  Tpcn1; two pore calcium channel protein 1 [KO:K16896]
117697935  Nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
117697965  Mcoln1; mucolipin-1 [KO:K04992]
117697985  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
117698148  P2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
117698163  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117698187  Tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
117698523  [KO:K05863]
117698610  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
117699053  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
117699236  Sln; sarcolipin [KO:K22642]
117699878  Pdgfd; platelet-derived growth factor D [KO:K05450]
117699942  Fgf5; fibroblast growth factor 5 [KO:K04358]
117700268  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
117700330  F2r; proteinase-activated receptor 1 [KO:K03914]
117700456  Calm3; calmodulin-3 [KO:K02183]
117700594  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
117701003  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117701071  Trdn; triadin [KO:K23449]
117701559  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117701820  [KO:K06268]
117702521  Tnnc2; troponin C, skeletal muscle [KO:K12042]
117702942  Ryr3; ryanodine receptor 3 [KO:K04963]
117703017  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117703121  P2rx3; P2X purinoceptor 3 [KO:K05217]
117703247  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
117703351  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
117703352  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
117703422  Fgf7; fibroblast growth factor 7 [KO:K04358]
117703435  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
117703529  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117703732  [KO:K04632]
117703734  [KO:K04632]
117703830  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
117703908  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
117703946  Ntsr1; neurotensin receptor type 1 [KO:K04211]
117703949  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117704121  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
117704198  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117704931  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
117704945  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
117704978  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
117704993  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
117705045  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117705062  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
117705132  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117705222  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
117705266  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
117705311  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117705334  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117705417  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
117705440  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117705452  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
117705469  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
117705533  Ednrb; endothelin receptor type B [KO:K04198]
117705560  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117705569  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
117705699  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
117705787  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
117706022  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
117706062  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
117706309  Fgf9; fibroblast growth factor 9 [KO:K04358]
117706566  Ngf; beta-nerve growth factor [KO:K02582]
117706598  C4H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
117706625  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117706647  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117706708  Grin2d; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
117706759  Fgf2; fibroblast growth factor 2 [KO:K18497]
117706968  Mcoln3; mucolipin-3 [KO:K04994]
117707131  Mcoln2; mucolipin-2 [KO:K04993]
117707138  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
117707235  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117707297  Agtr1; type-1 angiotensin II receptor [KO:K04166]
117707319  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
117707501  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
117707520  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
117707556  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
117707719  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
117707723  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117707829  Casq2; calsequestrin-2 [KO:K23445]
117707889  Tacr3; neuromedin-K receptor [KO:K04224]
117707912  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
117708831  Stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
117709021  Ptafr; platelet-activating factor receptor [KO:K04279]
117709331  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
117709538  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
117709539  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
117709867  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
117709948  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
117709997  Smim6; small integral membrane protein 6 [KO:K26468]
117710098  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
117710141  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
117710364  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
117710649  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
117710677  Nos2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
117710680  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
117710708  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
117710734  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
117710818  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117710870  Adora2b; adenosine receptor A2b [KO:K04267]
117710953  Fgf18; fibroblast growth factor 18 [KO:K04358]
117710955  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
117711430  Vdac1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
117711591  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
117711804  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117712005  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
117712027  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
117712038  P2rx5; P2X purinoceptor 5 [KO:K05219]
117712039  P2rx1; P2X purinoceptor 1 [KO:K05215]
117712457  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117712505  Drd5; D(1B) dopamine receptor [KO:K05840]
117712554  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117712590  Adcy1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
117712605  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
117712652  Stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
117712744  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117712829  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117712867  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
117712999  Cckar; cholecystokinin receptor type A [KO:K04194]
117713012  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
117713323  [KO:K04166]
117713333  Calml3; calmodulin-like protein 3 [KO:K02183]
117713400  Ryr2; ryanodine receptor 2 [KO:K04962]
117713440  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
117713532  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117713655  Camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
117713753  [KO:K05863]
117713886  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
117713892  Calml5; calmodulin-like protein 5 [KO:K02183]
117714098  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
117714206  Drd1; D(1A) dopamine receptor [KO:K04144]
117714375  Hrh2; histamine H2 receptor isoform X1 [KO:K04150]
117714391  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
117714682  Camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
117714693  Oxtr; oxytocin receptor [KO:K04229]
117714720  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
117714743  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117714778  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
117714976  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
117715086  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
117715132  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
117715153  Tacr1; substance-P receptor [KO:K04222]
117715216  [KO:K02183]
117715252  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
117715353  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
117715525  Fgf6; fibroblast growth factor 6 [KO:K04358]
117715613  Fgf23; fibroblast growth factor 23 [KO:K22428]
117715660  Tgfa; protransforming growth factor alpha [KO:K08774]
117715766  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117716078  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
117716104  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117716113  Atp2b4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
117716165  [KO:K04161]
117716225  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
117716334  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
117716563  Avpr1b; vasopressin V1b receptor [KO:K04227]
117716579  Camk1g; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
117716811  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117716931  Calm2; calmodulin-2 [KO:K02183]
117717043  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
117717067  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
117717149  Lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
117717499  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
117717634  [KO:K05862]
117717685  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117717686  Cckbr; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
117718445  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
117718548  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
117718712  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
117718733  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117718866  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
117719510  Adrb2; beta-2 adrenergic receptor [KO:K04142]
117719604  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
117719688  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117719853  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
117719854  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117720104  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117720109  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
117720132  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
117720319  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
117720320  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
117720523  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
117720551  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117720586  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
117720661  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
117720753  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
117720828  Gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
117720949  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
117721236  Vegfc; vascular endothelial growth factor C [KO:K05449]
117721474  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
117721707  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117721842  Fgf20; fibroblast growth factor 20 [KO:K04358]
117721874  Adrb3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
117721894  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
117721963  Casq1; calsequestrin-1 [KO:K23468]
117722071  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117722213  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
117722369  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
117722538  [KO:K02183]
117722602  Tfeb; transcription factor EB isoform X1 [KO:K15590]
117722924  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
117722946  Ptger1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
117723055  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117723064  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117723170  Ntrk3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
117723273  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
117723315  [KO:K04282]
117723386  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
117723408  Ednra; endothelin-1 receptor [KO:K04197]
117723492  Phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
117723537  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117723666  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
117723703  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
117724025  Fgf10; fibroblast growth factor 10 [KO:K04358]
117724294  Adrb1; beta-1 adrenergic receptor [KO:K04141]
117724336  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
117724452  Adora2a; adenosine receptor A2a [KO:K04266]
117724643  Tacr2; substance-K receptor [KO:K04223]
117724780  Pln; cardiac phospholamban [KO:K05852]
117724869  Mrln; myoregulin [KO:K22643]
117724924  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
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Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
anu04010  MAPK signaling pathway
anu04070  Phosphatidylinositol signaling system
anu04210  Apoptosis
anu04720  Long-term potentiation
anu04730  Long-term depression
KO pathway
ko04020   

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