KEGG   PATHWAY: cabi03040
Entry
cabi03040                   Pathway                                
Name
Spliceosome - Chelonoidis abingdonii (Abingdon island giant tortoise)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
cabi03040  Spliceosome
cabi03040

Other DBs
GO: 0005681
Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116814662  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
116814883  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
116814942  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
116815178  [KO:K14280]
116815217  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
116815358  [KO:K14278]
116815534  [KO:K14280]
116815585  [KO:K14280]
116815731  [KO:K14277]
116815774  [KO:K14279]
116815776  [KO:K14280]
116815807  [KO:K14278]
116815822  [KO:K14280]
116815839  ALYREF; THO complex subunit 4 [KO:K12881]
116815871  [KO:K14277]
116816010  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
116816207  [KO:K14277]
116816331  [KO:K14279]
116816418  [KO:K14276]
116816419  [KO:K14277]
116816551  [KO:K14280]
116816585  [KO:K14280]
116816617  [KO:K14276]
116816619  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
116816674  [KO:K14276]
116816771  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
116816935  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
116816996  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
116817267  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
116817390  [KO:K14276]
116817567  [KO:K14280]
116817588  [KO:K14278]
116817669  [KO:K14280]
116817915  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
116817929  MAGOH; protein mago nashi homolog [KO:K12877]
116817951  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
116818052  [KO:K14279]
116818090  [KO:K14278]
116818185  [KO:K14279]
116818260  [KO:K14276]
116818591  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
116818639  [KO:K14280]
116818692  [KO:K14280]
116818975  [KO:K14280]
116819080  [KO:K14280]
116819140  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
116819183  [KO:K14280]
116819377  [KO:K14276]
116819392  [KO:K14279]
116819399  [KO:K14280]
116819483  [KO:K14280]
116819511  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846]
116819539  [KO:K14280]
116819813  [KO:K14280]
116819889  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
116820049  [KO:K14276]
116820154  [KO:K14276]
116820179  TRA2B; transformer-2 protein homolog beta [KO:K12897]
116820186  [KO:K14278]
116820194  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
116820335  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
116820515  [KO:K14279]
116820590  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
116820608  [KO:K14277]
116820609  [KO:K14278]
116820857  RBM17; splicing factor 45 [KO:K12840]
116820859  [KO:K14276]
116820913  SRSF9; serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123]
116821008  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
116821028  [KO:K14280]
116821069  [KO:K14278]
116821447  [KO:K14279]
116821501  [KO:K12893]
116821515  [KO:K12893]
116821542  [KO:K14278]
116821580  [KO:K14280]
116821631  [KO:K14280]
116821639  [KO:K14280]
116821645  AQR; RNA helicase aquarius [KO:K12874]
116821671  [KO:K14276]
116821674  [KO:K14279]
116821819  [KO:K14278]
116821853  [KO:K14280]
116821974  [KO:K14276]
116822154  [KO:K14280]
116822498  [KO:K14277]
116822585  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
116822696  XAB2; pre-mRNA-splicing factor SYF1 isoform X1 [KO:K12867]
116822915  [KO:K12883]
116822928  PRPF18; pre-mRNA-splicing factor 18 [KO:K12817]
116822996  [KO:K14279]
116823001  [KO:K14279]
116823004  [KO:K14279]
116823118  [KO:K14278]
116823140  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
116823382  [KO:K14278]
116823627  [KO:K11097]
116823707  [KO:K14278]
116823800  [KO:K14278]
116823945  RP9; retinitis pigmentosa 9 protein [KO:K19604]
116823954  PQBP1; polyglutamine-binding protein 1 [KO:K12865]
116823988  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
116824079  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
116824130  [KO:K12896]
116824132  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
116824137  [KO:K12896]
116824237  SRSF1; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1 [KO:K12890]
116824385  [KO:K14280]
116824479  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
116824515  [KO:K14276]
116824556  [KO:K14280]
116824777  [KO:K14280]
116825139  [KO:K14278]
116825301  [KO:K14277]
116825386  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
116825390  [KO:K14280]
116825672  [KO:K14280]
116826224  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
116826260  [KO:K14279]
116826319  BUD31; protein BUD31 homolog [KO:K12873]
116826331  [KO:K14276]
116826375  [KO:K14280]
116826546  [KO:K14278]
116826649  [KO:K12811] [EC:5.6.2.7]
116826818  [KO:K14278]
116827090  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
116827116  [KO:K14276]
116827146  [KO:K14276]
116827234  [KO:K14280]
116827264  WBP11; WW domain-binding protein 11 [KO:K12866]
116827392  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
116827471  FUS; RNA-binding protein FUS [KO:K13098]
116827675  [KO:K14277]
116827785  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
116827917  SNRPE; small nuclear ribonucleoprotein E isoform X1 [KO:K11097]
116828006  [KO:K14280]
116828068  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
116828296  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
116828350  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
116828456  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
116828555  [KO:K14278]
116828775  SNU13; NHP2-like protein 1 [KO:K12845]
116828816  CDC40; pre-mRNA-processing factor 17 isoform X1 [KO:K12816]
116828883  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
116828968  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
116829047  [KO:K14279]
116829059  [KO:K14277]
116829060  [KO:K14278]
116829061  [KO:K14278]
116829062  [KO:K14278]
116829063  [KO:K14278]
116829066  [KO:K14278]
116829067  [KO:K14278]
116829068  [KO:K14278]
116829085  [KO:K14276]
116829333  [KO:K14276]
116829368  [KO:K14280]
116829445  PRPF8; pre-mRNA-processing-splicing factor 8 isoform X1 [KO:K12856]
116829802  [KO:K14277]
116829831  [KO:K14276]
116829832  [KO:K14279]
116829895  [KO:K12812] [EC:5.6.2.7]
116829929  [KO:K14280]
116830027  [KO:K14280]
116830112  THOC3; THO complex subunit 3 [KO:K12880]
116830198  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
116830214  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
116830239  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
116830321  [KO:K14280]
116830327  [KO:K14276]
116830359  [KO:K14277]
116830436  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
116830456  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
116830557  [KO:K14276]
116830570  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
116830592  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
116830700  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
116830816  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
116830844  [KO:K14276]
116830854  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
116830895  [KO:K14276]
116831144  [KO:K11098]
116831163  [KO:K14277]
116831250  [KO:K14276]
116831505  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
116831538  [KO:K14277]
116831736  [KO:K14276]
116831764  [KO:K14280]
116831856  RBM8A; RNA-binding protein 8A [KO:K12876]
116831862  [KO:K03283]
116831869  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
116831989  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
116832033  [KO:K14276]
116832090  [KO:K11098]
116832129  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
116832220  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
116832293  [KO:K14276]
116832295  [KO:K14277]
116832339  PRPF31; LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
116832359  U2AF2; splicing factor U2AF 65 kDa subunit [KO:K12837]
116832554  [KO:K14279]
116832662  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
116833108  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
116833142  [KO:K14277]
116833233  [KO:K14280]
116833283  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
116833378  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
116833499  [KO:K14280]
116833633  [KO:K14278]
116833655  [KO:K14276]
116833721  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
116833727  [KO:K14277]
116833728  [KO:K14277]
116833766  [KO:K14278]
116833801  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
116833814  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
116833870  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
116833913  [KO:K14278]
116833924  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
116833969  [KO:K14280]
116834030  [KO:K14276]
116834061  CRNKL1; crooked neck-like protein 1 [KO:K12869]
116834114  [KO:K14277]
116834184  [KO:K11098]
116834272  [KO:K14276]
116834292  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
116834508  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
116834727  [KO:K14278]
116834817  [KO:K14280]
116834894  [KO:K14280]
116834926  [KO:K14276]
116835281  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
116835325  [KO:K14277]
116835425  [KO:K14280]
116835917  [KO:K12887]
116835975  LSM2; LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
116836183  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
116836308  [KO:K14277]
116836350  [KO:K14277]
116836354  [KO:K14277]
116836540  [KO:K14279]
116836626  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
116836817  [KO:K14280]
116836933  [KO:K14278]
116837019  HNRNPU; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein U [KO:K12888]
116837081  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
116837138  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
116837201  [KO:K14277]
116837259  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
116837260  [KO:K14278]
116837338  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
116837404  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
116837527  SNW1; SNW domain-containing protein 1 [KO:K06063]
116837547  [KO:K14277]
116837560  CDC5L; cell division cycle 5-like protein [KO:K12860]
116837638  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
116837724  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
116837771  [KO:K14278]
116837832  [KO:K14280]
116837960  [KO:K03283]
116838017  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
116838172  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
116838295  [KO:K14277]
116838307  ACIN1; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
116838436  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
116838441  [KO:K14280]
116838484  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
116838511  [KO:K14276]
116838522  [KO:K14280]
116838535  [KO:K14278]
116838675  [KO:K14276]
116838687  DHX38; LOW QUALITY PROTEIN: pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
116838740  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
116838820  SART1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984]
116839069  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
116839136  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
116839340  [KO:K14280]
116839432  [KO:K14277]
116839521  ISY1; pre-mRNA-splicing factor ISY1 homolog isoform X1 [KO:K12870]
116839584  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
116839596  [KO:K14277]
116839720  [KO:K14280]
116839723  [KO:K14280]
116840059  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
116840078  [KO:K11098]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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