KEGG   PATHWAY: cfa04115
Entry
cfa04115                    Pathway                                
Name
p53 signaling pathway - Canis lupus familiaris (dog)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
cfa04115  p53 signaling pathway
cfa04115

Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
479450  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
486338  CHEK2; serine/threonine-protein kinase Chk2 isoform X3 [KO:K06641] [EC:2.7.11.1]
100856315  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
609767  CHEK1; serine/threonine-protein kinase Chk1 isoform X8 [KO:K02216] [EC:2.7.11.1]
490349  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
403693  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
478939  MDM4; protein Mdm4 isoform X1 [KO:K10127]
403869  TP53; cellular tumor antigen p53 [KO:K04451]
612286  PPP1R13L; relA-associated inhibitor isoform X1 [KO:K27356]
474890  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
449028  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
611782  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
608847  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
481131  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
612475  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
609920  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
484610  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
487057  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100855704  CDK2; cyclin-dependent kinase 2 isoform X3 [KO:K02206] [EC:2.7.11.22]
487351  SFN; 14-3-3 protein sigma [KO:K06644]
119867787  RPRM; protein reprimo [KO:K10128]
608420  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
487020  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
478324  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100856079  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
484198  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
485069  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100855728  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X2 [KO:K04402]
608855  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
477591  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
486469  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
483649  PIDD1; p53-induced death domain-containing protein 1 isoform X4 [KO:K10130]
100688321  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
488473  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100683675  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
403523  BAX; apoptosis regulator BAX [KO:K02159]
100502558  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
612153  BBC3; bcl-2-binding component 3 [KO:K10132]
612693  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
106559278  LOW QUALITY PROTEIN: apoptosis regulatory protein Siva-like [KO:K22744]
403618  BCL2L1; bcl-2-like protein 1 [KO:K04570]
403416  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
610825  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
489301  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
609054  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
476218  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
100855542  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
100856496  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
475258  CYCS; cytochrome c [KO:K08738]
100689004  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
482620  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
487432  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
403567  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
479236  AIFM2; ferroptosis suppressor protein 1 isoform X3 [KO:K22745]
100855619  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
610255  IGF1; insulin-like growth factor I precursor [KO:K05459]
403476  SERPINE1; plasminogen activator inhibitor 1 precursor [KO:K03982]
100683150  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
487486  THBS1; thrombospondin-1 [KO:K16857]
476177  SERPINB5; serpin B5 isoform X2 [KO:K10139]
483626  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
481988  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X4 [KO:K10808] [EC:1.17.4.1]
482963  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
481956  SESN1; sestrin-1 isoform X2 [KO:K10141]
485118  SESN3; sestrin-3 isoform X2 [KO:K10141]
487335  SESN2; sestrin-2 [KO:K20394]
403832  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
479883  TSC2; tuberin isoform X1 [KO:K07207]
483885  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
480060  COP1; E3 ubiquitin-protein ligase COP1 isoform X6 [KO:K10143] [EC:2.3.2.27]
612746  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X7 [KO:K10144] [EC:2.3.2.27]
479303  CCNG1; cyclin-G1 [KO:K10145]
100683637  LOW QUALITY PROTEIN: cyclin-G1-like [KO:K10145]
478442  CCNG2; cyclin-G2 [KO:K10146]
612934  PPM1D; protein phosphatase 1D isoform X2 [KO:K10147] [EC:3.1.3.16]
489620  TP73; tumor protein p73 isoform X28 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
cfa04110  Cell cycle
cfa04210  Apoptosis
cfa04218  Cellular senescence
KO pathway
ko04115   
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