KEGG   PATHWAY: cjc04218
Entry
cjc04218                    Pathway                                
Name
Cellular senescence - Callithrix jacchus (white-tufted-ear marmoset)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
cjc04218  Cellular senescence
cjc04218

Other DBs
GO: 0090398
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385008  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100385528  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
100385604  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100385650  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
100385763  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100386369  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
100386452  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100386453  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100386590  ZFP36L2; mRNA decay activator protein ZFP36L2 [KO:K18753]
100386626  [KO:K07830]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100387000  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
100387059  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100387811  CAJA-E; patr class I histocompatibility antigen, alpha chain E precursor [KO:K06751]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100388085  [KO:K05868]
100388148  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100388209  [KO:K06751]
100388293  CCNA2; cyclin-A2 [KO:K06627]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100388551  [KO:K10752]
100388842  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
100389218  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
100389596  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100390172  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100390180  CALM1; calmodulin-1 [KO:K02183]
100390190  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
100390235  E2F3; transcription factor E2F3 isoform X4 [KO:K06620]
100390244  HIPK4; homeodomain-interacting protein kinase 4 isoform X1 [KO:K08826] [EC:2.7.11.1]
100390332  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
100390586  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100390587  CXCL8; interleukin-8 [KO:K10030]
100390664  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
100390719  TRAF3IP2; E3 ubiquitin ligase TRAF3IP2 isoform X1 [KO:K21124]
100390843  [KO:K04960]
100391291  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
100391612  [KO:K06269] [EC:3.1.3.16]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100392363  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100392463  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100392509  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100392986  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100393051  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100393258  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100393460  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100393808  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
100393906  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100394189  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100394399  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100394435  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100394742  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
100395149  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
100395618  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100396059  HUS1; checkpoint protein HUS1 [KO:K10903]
100396301  [KO:K06643] [EC:2.3.2.27]
100396453  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100396487  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
100396520  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100396826  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100397122  MYBL2; myb-related protein B isoform X1 [KO:K21769]
100397220  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100397389  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
100397393  FOXO1; forkhead box protein O1 [KO:K07201]
100397928  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100397940  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
100398162  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100398346  RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
100398361  [KO:K06751]
100398593  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100398703  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100399078  [KO:K06751]
100399481  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100399873  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
100400537  [KO:K07830]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100400963  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
100401153  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
100401286  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100401891  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
100401979  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100402258  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100402300  FBXW11; F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
100402387  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100403262  [KO:K10867]
100403424  [KO:K05863]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100403750  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100403881  LIN54; protein lin-54 homolog isoform X1 [KO:K21776]
100404125  LIN9; protein lin-9 homolog isoform X2 [KO:K21773]
100404154  [KO:K21769]
100404359  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100404435  TRPV4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100404537  [KO:K05863]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100404949  CHEK2; serine/threonine-protein kinase Chk2 isoform X5 [KO:K06641] [EC:2.7.11.1]
100405035  RAD9A; cell cycle checkpoint control protein RAD9A isoform X2 [KO:K10994] [EC:3.1.11.2]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100405128  [KO:K06751]
100405187  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100405215  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100405281  ZFP36L1; mRNA decay activator protein ZFP36L1 [KO:K18753]
100405303  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100405400  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
100405490  [KO:K05863]
100405678  NBN; nibrin isoform X1 [KO:K10867]
100405844  [KO:K05863]
100406017  HRAS; GTPase HRas [KO:K02833]
100406081  CALM3; calmodulin-3 [KO:K02183]
100406240  [KO:K06751]
100406246  HIPK2; homeodomain-interacting protein kinase 2 isoform X6 [KO:K08826] [EC:2.7.11.1]
100406401  IL1A; interleukin-1 alpha [KO:K04383]
100406446  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
100406608  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100406801  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100406981  RAD9B; cell cycle checkpoint control protein RAD9B isoform X4 [KO:K10995]
100407357  HIPK3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
100407741  TSC1; hamartin isoform X2 [KO:K07206]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100408249  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100408259  LIN37; protein lin-37 homolog isoform X1 [KO:K21774]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100408304  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100408321  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100408832  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
100409380  [KO:K05863]
100409607  [KO:K05864] [EC:5.2.1.8]
100410298  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100410315  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
100410496  [KO:K06269] [EC:3.1.3.16]
100410955  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
100411069  [KO:K06751]
100411097  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
100411213  ETS1; protein C-ets-1 isoform X6 [KO:K02678]
100411371  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100411448  LIN52; protein lin-52 homolog isoform X1 [KO:K21775]
100411549  HIPK1; homeodomain-interacting protein kinase 1 isoform X3 [KO:K08826] [EC:2.7.11.1]
100411931  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
100412164  FOXM1; forkhead box protein M1 isoform X2 [KO:K09406]
100412321  ATR; serine/threonine-protein kinase ATR isoform X4 [KO:K06640] [EC:2.7.11.1]
100412572  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100413772  RRAS; ras-related protein R-Ras [KO:K07829]
100413890  E2F4; transcription factor E2F4 isoform X2 [KO:K04682]
100414261  E2F1; transcription factor E2F1 [KO:K17454]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100414776  E2F2; transcription factor E2F2 [KO:K09389]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
100414856  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100415559  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
100415620  [KO:K06643] [EC:2.3.2.27]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108588103  [KO:K05863]
108591807  [KO:K07828]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118144170  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
118148021  [KO:K02183]
118151094  [KO:K06751]
118151319  [KO:K06751]
128930731  [KO:K05863]
128931276  [KO:K07830]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
cjc04020  Calcium signaling pathway
cjc04068  FoxO signaling pathway
cjc04110  Cell cycle
cjc04115  p53 signaling pathway
cjc04150  mTOR signaling pathway
KO pathway
ko04218   

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