KEGG   PATHWAY: cpoc04666
Entry
cpoc04666                   Pathway                                
Name
Fc gamma R-mediated phagocytosis - Cavia porcellus (domestic guinea pig)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
cpoc04666  Fc gamma R-mediated phagocytosis
cpoc04666

Other DBs
GO: 0006909
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100721479  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100722313  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100722862  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100723692  putative high affinity immunoglobulin gamma Fc receptor IC [KO:K06498]
101787193  Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X2 [KO:K06472]
101788791  low affinity immunoglobulin gamma Fc region receptor IV isoform X1 [KO:K06463]
100730564  Ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
100714976  Hck; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
100714653  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100716985  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100720622  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100727986  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100735084  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100734206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100730242  Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100734044  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100719925  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714724  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100724315  Akt3; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100727216  Rps6kb1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100722430  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100716986  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100726796  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100726624  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
100721814  Prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
100720110  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100712888  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100715719  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100735123  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100734841  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100721732  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100726758  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X4 [KO:K16343] [EC:3.1.1.4]
100728244  Marcksl1; MARCKS-related protein [KO:K13536]
100734216  Pld1; LOW QUALITY PROTEIN: phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100721224  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100734582  Plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
100713443  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
100135603  Plpp1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
100730608  Sphk2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100727266  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100713627  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100717697  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100733947  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100726055  Ncf1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
100726389  Scin; adseverin [KO:K05768]
100722590  Gsn; gelsolin isoform X1 [KO:K05768]
100713221  Vav1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
100714719  Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100728155  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100717195  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100730969  Was; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein [KO:K05747]
100722137  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100726741  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
100713982  Actr3; actin-related protein 3 isoform X1 [KO:K18584]
100716996  Actr3b; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
100723268  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100723542  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100723870  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100727633  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100718918  Arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
100733699  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100731671  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100727219  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100731468  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
100716147  Wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
100723274  Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
100718803  Wasf3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
100714662  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100712921  Limk1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
100720658  Limk2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
100727405  Cfl2; cofilin-2 isoform X1 [KO:K05765]
100732287  Cfl1; cofilin-1 [KO:K05765]
100715277  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
100728992  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100717867  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100726124  Arf6; ADP-ribosylation factor 6 [KO:K07941]
100718486  Crk; adapter molecule crk [KO:K04438]
100723968  Crkl; crk-like protein [KO:K04438]
100734315  Dock1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
100714955  Asap3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
100722888  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
100726170  Asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
100192391  Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II precursor [KO:K12560]
100722743  Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
100725170  Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
100732375  Gab2; GRB2-associated-binding protein 2 [KO:K08091]
100723774  Lat; linker for activation of T-cells family member 1 isoform X3 [KO:K07362]
100717689  Dnm2; dynamin-2 isoform X5 [KO:K23484] [EC:3.6.5.5]
100717746  Amph; amphiphysin isoform X1 [KO:K12562]
100722858  Bin1; myc box-dependent-interacting protein 1 [KO:K12562]
100721140  Myo10; unconventional myosin-X isoform X1 [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
cpoc04020  Calcium signaling pathway
cpoc04142  Lysosome
cpoc04144  Endocytosis
cpoc04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
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