KEGG   PATHWAY: cpoc04020
Entry
cpoc04020                   Pathway                                
Name
Calcium signaling pathway - Cavia porcellus (domestic guinea pig)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
cpoc04020  Calcium signaling pathway
cpoc04020

Other DBs
GO: 0019722
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100724486  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
100135620  Slc8a1; sodium/calcium exchanger 1 precursor [KO:K05849]
100729052  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
100729216  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
100337639  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100337638  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
100728391  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100728041  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
100379235  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
100379240  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
100135473  Adora2a; adenosine receptor A2a [KO:K04266]
100727842  Adora2b; adenosine receptor A2b [KO:K04267]
100379595  Adrb1; beta-1 adrenergic receptor [KO:K04141]
100722663  Adrb2; beta-2 adrenergic receptor [KO:K04142]
100135478  Adrb3; beta-3 adrenergic receptor [KO:K04143]
100729180  Drd1; D(1A) dopamine receptor [KO:K04144]
100732538  Drd5; D(1B) dopamine receptor [KO:K05840]
100729734  Hrh2; histamine H2 receptor [KO:K04150]
100135548  Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
100715649  5-hydroxytryptamine receptor 5B-like [KO:K04161]
100379278  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
100723275  Htr6; 5-hydroxytryptamine receptor 6 isoform X2 [KO:K04162]
100135549  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100732158  neuroendocrine secretory protein 55-like [KO:K04632]
100732436  guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
100716796  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
100715672  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100731999  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100725667  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100715532  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100726699  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100722340  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100717226  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100735694  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100712694  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100721387  Pln; cardiac phospholamban [KO:K05852]
101787645  Sln; sarcolipin [KO:K22642]
106028476  Mrln; myoregulin [KO:K22643]
106027660  Smim6; small integral membrane protein 6 [KO:K26468]
100726234  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100174979  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
100174978  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100726451  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
100728201  Stim1; stromal interaction molecule 1 isoform X5 [KO:K16059]
100715969  Stim2; stromal interaction molecule 2 [KO:K18196]
100725803  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
111753263  Orai2; protein orai-2 isoform X2 [KO:K16057]
100715641  Orai3; protein orai-3 [KO:K16058]
100135490  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100726255  Cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100720484  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100734741  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100726277  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100735203  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100716749  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X6 [KO:K04852]
100728128  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X22 [KO:K04854]
100720102  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X3 [KO:K04855]
100735927  Cacna1i; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100720640  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100301989  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
100727265  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100731840  Grin2b; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100721967  Grin2c; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100731717  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100721429  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X2 [KO:K05213]
100726052  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
100727772  P2rx1; P2X purinoceptor 1 [KO:K05215]
100135591  P2rx2; P2X purinoceptor 2 [KO:K05216]
100722959  P2rx3; P2X purinoceptor 3 [KO:K05217]
100716323  P2rx4; P2X purinoceptor 4 [KO:K05218]
100731287  P2rx5; P2X purinoceptor 5 [KO:K05219]
100732430  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
100379234  P2rx7; P2X purinoceptor 7 [KO:K05220]
100727848  Ryr1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
100731307  Ryr2; ryanodine receptor 2 [KO:K04962]
100724592  Ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
100729509  Trdn; triadin [KO:K23449]
100730063  Casq1; calsequestrin-1 [KO:K23468]
100722777  Casq2; calsequestrin-2 [KO:K23445]
100726813  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X4 [KO:K00476] [EC:1.14.11.16]
100135514  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
100379529  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
100715343  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
100135474  Adra1a; alpha-1A adrenergic receptor [KO:K04135]
100735480  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
100735770  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
100192325  Agtr1; type-1 angiotensin II receptor [KO:K04166]
100723122  Ednra; LOW QUALITY PROTEIN: endothelin-1 receptor [KO:K04197]
100725686  Ednrb; LOW QUALITY PROTEIN: endothelin receptor type B [KO:K04198]
100719323  F2r; proteinase-activated receptor 1 [KO:K03914]
100730891  Grm1; metabotropic glutamate receptor 1 [KO:K04603]
100714109  metabotropic glutamate receptor 5 [KO:K04604]
100734491  Grpr; gastrin-releasing peptide receptor [KO:K04169]
100730517  Hrh1; histamine H1 receptor isoform X2 [KO:K04149]
100135545  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
100169693  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
100135546  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
100731114  Lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
100735331  Ntsr1; neurotensin receptor type 1 [KO:K04211]
100721402  Oxtr; oxytocin receptor isoform X1 [KO:K04229]
100733909  Avpr1a; vasopressin V1a receptor isoform X1 [KO:K04226]
100717018  Avpr1b; vasopressin V1b receptor [KO:K04227]
100735016  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
100720710  Ptafr; platelet-activating factor receptor [KO:K04279]
100719923  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100719742  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100735880  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
100135486  Bdkrb2; B2 bradykinin receptor [KO:K03916]
100135626  Tacr1; substance-P receptor isoform long [KO:K04222]
100720631  Tacr2; substance-K receptor [KO:K04223]
100135627  Tacr3; neuromedin-K receptor [KO:K04224]
100717592  Tbxa2r; thromboxane A2 receptor [KO:K04264]
100725810  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
100729898  thyrotropin-releasing hormone receptor-like [KO:K04282]
100719593  Cckar; cholecystokinin receptor type A [KO:K04194]
100720322  Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195]
100731341  Cxcr4; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4 [KO:K04189]
100714586  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100715351  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100731029  Gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100732697  guanine nucleotide-binding protein subunit alpha-15-like [KO:K04637]
100714518  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
100714471  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
100731469  Pdgfb; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100722571  Pdgfc; platelet-derived growth factor C [KO:K05450]
100713757  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
100727152  Fgf1; fibroblast growth factor 1 isoform X2 [KO:K18496]
100721182  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100722934  Fgf5; fibroblast growth factor 5 isoform X2 [KO:K04358]
100730085  Fgf10; fibroblast growth factor 10 [KO:K04358]
100723648  Fgf16; fibroblast growth factor 16 [KO:K04358]
100730876  Fgf6; fibroblast growth factor 6 [KO:K04358]
100727356  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100718957  Fgf7; fibroblast growth factor 7 [KO:K04358]
100715152  Fgf18; fibroblast growth factor 18 [KO:K04358]
100732836  Fgf20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
100727609  Fgf9; fibroblast growth factor 9 [KO:K04358]
100716446  Fgf3; fibroblast growth factor 3 [KO:K04358]
100730350  Fgf4; fibroblast growth factor 4 [KO:K04358]
100721186  Fgf22; fibroblast growth factor 22 [KO:K04358]
100728398  Fgf21; fibroblast growth factor 21 [KO:K22429]
100717518  Fgf23; fibroblast growth factor 23 [KO:K22428]
100713483  Vegfa; vascular endothelial growth factor A isoform X2 [KO:K05448]
100724743  Vegfb; vascular endothelial growth factor B isoform X2 [KO:K16858]
100724469  Vegfc; vascular endothelial growth factor C [KO:K05449]
100733371  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
100733367  Ngf; beta-nerve growth factor [KO:K02582]
100730730  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100734937  Mst1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100717276  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100725363  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100727657  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100712946  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100724678  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100726209  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100726506  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100731156  Fgfr1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100379152  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100732948  Fgfr3; fibroblast growth factor receptor 3 isoform X9 [KO:K05094] [EC:2.7.10.1]
100733523  Fgfr4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100732326  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100715831  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100726761  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100725325  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100723565  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
106028780  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
100731493  Ntrk3; NT-3 growth factor receptor isoform X2 [KO:K05101] [EC:2.7.10.1]
100718790  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100732415  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
100733392  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100726088  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4 [KO:K05857] [EC:3.1.4.11]
100715613  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
100724912  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3 [KO:K05857] [EC:3.1.4.11]
100729394  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100714143  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
100727662  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100730572  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100716986  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100726796  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100721203  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100716367  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
100713023  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100717278  Itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100729184  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
100726537  Cd38; LOW QUALITY PROTEIN: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
106026535  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100717872  Tpcn1; two pore calcium channel protein 1 [KO:K16896]
100729259  Tpcn2; two pore calcium channel protein 2 isoform X2 [KO:K14077]
100719219  Mcoln1; mucolipin-1 [KO:K04992]
100730589  Mcoln2; mucolipin-2 [KO:K04993]
100735790  Mcoln3; mucolipin-3 [KO:K04994]
100730608  Sphk2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100727266  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100715815  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
100723897  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100723838  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100728777  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
100728327  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
100722530  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
100722295  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
100725941  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100730526  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100727660  Tnnc2; troponin C, skeletal muscle [KO:K12042]
100728342  Calml3; calmodulin-like protein 3 [KO:K02183]
100730149  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100734544  Calm1; calmodulin-1 [KO:K02183]
100728625  calmodulin-4 [KO:K02183]
100729712  calmodulin-like [KO:K02183]
106027819  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100169692  Calm3; calmodulin [KO:K02183]
100724214  Calm2; calmodulin [KO:K02183]
100714336  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
100732648  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
100724099  Phkb; phosphorylase b kinase regulatory subunit beta [KO:K07190]
100726293  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
100719858  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100728232  Mylk3; myosin light chain kinase 3 isoform X3 [KO:K00907] [EC:2.7.11.18]
100724875  Mylk2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100721558  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100724747  Camk1d; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
100712760  Camk1g; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
100731166  Camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X4 [KO:K08794] [EC:2.7.11.17]
100727059  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
100725858  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100719406  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X12 [KO:K04515] [EC:2.7.11.17]
100717077  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
100723881  Camk4; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100727741  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100725315  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100728974  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
106027879  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100721882  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
100719617  Tfeb; transcription factor EB [KO:K15590]
100730044  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X4 [KO:K04446]
100722868  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
100728433  Nfatc3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100734178  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
100729682  Nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100135576  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100135577  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100726194  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
100527956  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
100527959  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
100734027  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100725789  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
100733156  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101787457  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100713627  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100717697  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100733947  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
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Ferrier GR, Howlett SE.
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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PMID:11698232
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Keef KD, Hume JR, Zhong J.
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
PMID:10997573
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Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
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Reference
PMID:10508738
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Grewal SS, York RD, Stork PJ.
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
PMID:12972622
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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PMID:14517314
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
PMID:21338471
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
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Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
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Reference
PMID:19434403
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
cpoc04010  MAPK signaling pathway
cpoc04070  Phosphatidylinositol signaling system
cpoc04210  Apoptosis
cpoc04720  Long-term potentiation
cpoc04730  Long-term depression
KO pathway
ko04020   
LinkDB

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