KEGG   PATHWAY: dme00230
Entry
dme00230                    Pathway                                
Name
Purine metabolism - Drosophila melanogaster (fruit fly)
Class
Metabolism; Nucleotide metabolism
Pathway map
dme00230  Purine metabolism
dme00230

Module
dme_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:dme00230]
dme_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:dme00230]
dme_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:dme00230]
dme_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:dme00230]
dme_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:dme00230]
dme_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:dme00230]
dme_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:dme00230]
Other DBs
GO: 0006163 0042278
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG10078  Prat2; phosphoribosylamidotransferase 2, isoform B [KO:K00764] [EC:2.4.2.14]
Dmel_CG10143  Adgf-E; adenosine deaminase-related growth factor E [KO:K19572] [EC:3.5.4.4]
Dmel_CG10202  Pgm2b; phosphoglucomutase 2b [KO:K15779] [EC:5.4.2.2 5.4.2.7]
Dmel_CG10564  Ac78C; adenylyl cyclase 78C, isoform B [KO:K08048] [EC:4.6.1.1]
Dmel_CG10581  CG10581; uncharacterized protein [KO:K06928] [EC:3.6.1.15]
Dmel_CG11050  CG11050; uncharacterized protein, isoform A [KO:K07023] [EC:3.1.3.89]
Dmel_CG11089  CG11089; uncharacterized protein, isoform B [KO:K00602] [EC:2.1.2.3 3.5.4.10]
Dmel_CG11255  Adk2; adenosine kinase 2, isoform C [KO:K00856] [EC:2.7.1.20]
Dmel_CG11811  CG11811; uncharacterized protein [KO:K00942] [EC:2.7.4.8]
Dmel_CG11883  CG11883; uncharacterized protein, isoform C [KO:K01081] [EC:3.1.3.5]
Dmel_CG11900  Mesh1; metazoan SpoT homolog-1 [KO:K21138] [EC:3.1.7.2]
Dmel_CG1470  Gycbeta100B; guanylyl cyclase beta-subunit at 100B [KO:K12319] [EC:4.6.1.2]
Dmel_CG14885  Gyc89Da; guanylyl cyclase at 89Da, isoform C [KO:K01769] [EC:4.6.1.2]
Dmel_CG14886  Gyc89Db; guanylyl cyclase at 89Db [KO:K01769] [EC:4.6.1.2]
Dmel_CG1506  Ac3; adenylate cyclase 3, isoform C [KO:K08043] [EC:4.6.1.1]
Dmel_CG15547  CG15547; uncharacterized protein [KO:K00940] [EC:2.7.4.6]
Dmel_CG16758  CG16758; uncharacterized protein, isoform G [KO:K03783] [EC:2.4.2.1]
Dmel_CG17146  Ak1; adenylate kinase 1, isoform B [KO:K00939] [EC:2.7.4.3]
Dmel_CG17174  ACXB; adenylyl cyclase X B [KO:K01768] [EC:4.6.1.1]
Dmel_CG17176  ACXA; adenylyl cyclase X A, isoform C [KO:K01768] [EC:4.6.1.1]
Dmel_CG17178  ACXE; adenylyl cyclase X E [KO:K01768] [EC:4.6.1.1]
Dmel_CG17273  Adss; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
Dmel_CG1799  ras; raspberry, isoform D [KO:K00088] [EC:1.1.1.205]
Dmel_CG18128  CG18128; uncharacterized protein [KO:K03783] [EC:2.4.2.1]
Dmel_CG18143  DhpD; dihydropterin deaminase [KO:K01487] [EC:3.5.4.3]
Dmel_CG18315  Aprt; adenine phosphoribosyltransferase, isoform C [KO:K00759] [EC:2.4.2.7]
Dmel_CG1851  Adk3; adenosine kinase 3 [KO:K00856] [EC:2.7.1.20]
Dmel_CG18516  AOX4; aldehyde oxidase 4 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dmel_CG18519  AOX2; aldehyde oxidase 2 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dmel_CG18522  AOX1; aldehyde oxidase 1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dmel_CG1912  Gycalpha99B; guanylyl cyclase alpha-subunit at 99B [KO:K12318] [EC:4.6.1.2]
Dmel_CG2210  awd; abnormal wing discs, isoform E [KO:K00940] [EC:2.7.4.6]
Dmel_CG2867  Prat; phosphoribosylamidotransferase, isoform B [KO:K00764] [EC:2.4.2.14]
Dmel_CG30016  CG30016; uncharacterized protein [KO:K07127] [EC:3.5.2.17]
Dmel_CG30103  CG30103; uncharacterized protein [KO:K19970] [EC:3.1.3.5]
Dmel_CG30104  NT5E-2; Ecto-5'-nucleotidase 2, isoform A [KO:K19970] [EC:3.1.3.5]
Dmel_CG3059  NTPase; NTPase, isoform F [KO:K01511] [EC:3.6.1.6]
Dmel_CG31183  CG31183; uncharacterized protein, isoform B [KO:K12323] [EC:4.6.1.2]
Dmel_CG3140  Ak2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
Dmel_CG31628  Gart; GART trifunctional enzyme, isoform C [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
Dmel_CG31713  Datp; diadenosine tetraphosphatase [KO:K01518] [EC:3.6.1.17]
Dmel_CG3216  CG3216; uncharacterized protein, isoform D [KO:K12323] [EC:4.6.1.2]
Dmel_CG32178  Adgf-A2; adenosine deaminase-related growth factor A2, isoform B [KO:K19572] [EC:3.5.4.4]
Dmel_CG32301  CG32301; uncharacterized protein, isoform B [KO:K01768] [EC:4.6.1.1]
Dmel_CG32305  CG32305; uncharacterized protein [KO:K01768] [EC:4.6.1.1]
Dmel_CG32498  dnc; dunce, isoform F [KO:K13293] [EC:3.1.4.53]
Dmel_CG32549  Nt5b; 5' nucleotidase B, isoform D [KO:K01081] [EC:3.1.3.5]
Dmel_CG32626  AMPdeam; AMP deaminase, isoform H [KO:K01490] [EC:3.5.4.6]
Dmel_CG33114  Gyc32E; guanylyl cyclase at 32E, isoform D [KO:K01769] [EC:4.6.1.2]
Dmel_CG34341  Pde11; phosphodiesterase 11, isoform F [KO:K13298] [EC:3.1.4.17 3.1.4.35]
Dmel_CG34357  CG34357; uncharacterized protein, isoform D [KO:K12322] [EC:4.6.1.2]
Dmel_CG3461  pn; prune [KO:K01514] [EC:3.6.1.11]
Dmel_CG3590  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
Dmel_CG3809  Adk1; adenosine kinase 1 [KO:K00856] [EC:2.7.1.20]
Dmel_CG3989  Paics; PAICS bifunctional enzyme, isoform A [KO:K01587] [EC:4.1.1.21 6.3.2.6]
Dmel_CG4098  CG4098; uncharacterized protein [KO:K13988] [EC:3.6.1.13]
Dmel_CG4154  Gyc88E; guanylyl cyclase at 88E, isoform D [KO:K01769] [EC:4.6.1.2]
Dmel_CG42276  Pde9; phosphodiesterase 9, isoform E [KO:K13761] [EC:3.1.4.35]
Dmel_CG42636  Gyc76C; guanylyl cyclase at 76C, isoform A [KO:K01769] [EC:4.6.1.2]
Dmel_CG42637  CG42637; uncharacterized protein, isoform C [KO:K01769] [EC:4.6.1.2]
Dmel_CG44007  Pde1c; phosphodiesterase 1c, isoform B [KO:K13755] [EC:3.1.4.17]
Dmel_CG45019  Pde8; phosphodiesterase 8, isoform I [KO:K18437] [EC:3.1.4.53]
Dmel_CG4827  veil; veil, isoform B [KO:K19970] [EC:3.1.3.5]
Dmel_CG5165  Pgm1; phosphoglucose mutase 1 [KO:K01835] [EC:5.4.2.2]
Dmel_CG5276  CG5276; uncharacterized protein, isoform B [KO:K12304] [EC:3.6.1.6]
Dmel_CG5310  [KO:K00940] [EC:2.7.4.6]
Dmel_CG5371  RnrL; ribonucleoside diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
Dmel_CG5452  dnk; deoxyribonucleoside kinase, isoform B [KO:K05961] [EC:2.7.1.145]
Dmel_CG5712  ACXD; adenylyl cyclase X D, isoform B [KO:K01768] [EC:4.6.1.1]
Dmel_CG5983  ACXC; adenylyl cyclase X C, isoform B [KO:K01768] [EC:4.6.1.1]
Dmel_CG5992  Adgf-A; adenosine deaminase-related growth factor A, isoform A [KO:K19572] [EC:3.5.4.4]
Dmel_CG5998  Adgf-B; adenosine deaminase-related growth factor B [KO:K19572] [EC:3.5.4.4]
Dmel_CG6045  AOX3; aldehyde oxidase 3, isoform B [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dmel_CG6106  CG6106; uncharacterized protein, isoform B [KO:K01466] [EC:3.5.2.5]
Dmel_CG6612  Ak3; adenylate kinase 3, isoform C [KO:K00944] [EC:2.7.4.10]
Dmel_CG6767  Prps; phosphoribosyl pyrophosphate synthetase, isoform C [KO:K00948] [EC:2.7.6.1]
Dmel_CG7171  Uro; urate oxidase [KO:K00365] [EC:1.7.3.3]
Dmel_CG7642  ry; rosy [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dmel_CG7978  Ac76E; adenylyl cyclase 76E, isoform A [KO:K08042] [EC:4.6.1.1]
Dmel_CG8073  Pgm2a; phosphoglucomutase 2a [KO:K01835] [EC:5.4.2.2]
Dmel_CG8279  Pde6; phosphodiesterase 6, isoform D [KO:K13763] [EC:3.1.4.35]
Dmel_CG8362  [KO:K00940] [EC:2.7.4.6]
Dmel_CG8363  Papss; PAPS synthetase, isoform F [KO:K13811] [EC:2.7.7.4 2.7.1.25]
Dmel_CG8816  Ak6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
Dmel_CG8891  CG8891; uncharacterized protein [KO:K01519] [EC:3.6.1.66]
Dmel_CG8975  RnrS; ribonucleoside diphosphate reductase small subunit [KO:K10808] [EC:1.17.4.1]
Dmel_CG9127  Pfas; phosphoribosylformylglycinamidine synthase, isoform A [KO:K01952] [EC:6.3.5.3]
Dmel_CG9210  Ac13E; adenylyl cyclase 13E, isoform B [KO:K08049] [EC:4.6.1.1]
Dmel_CG9242  bur; burgundy, isoform C [KO:K01951] [EC:6.3.5.2]
Dmel_CG9296  PrBP; Prenyl-binding protein [KO:K13758]
Dmel_CG9345  Adgf-C; adenosine deaminase-related growth factor C [KO:K19572] [EC:3.5.4.4]
Dmel_CG9533  rut; rutabaga, isoform A [KO:K08041] [EC:4.6.1.1]
Dmel_CG9621  Adgf-D; adenosine deaminase-related growth factor D [KO:K19572] [EC:3.5.4.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
dme00030  Pentose phosphate pathway
dme00220  Arginine biosynthesis
dme00250  Alanine, aspartate and glutamate metabolism
dme00260  Glycine, serine and threonine metabolism
dme00340  Histidine metabolism
dme00630  Glyoxylate and dicarboxylate metabolism
dme00730  Thiamine metabolism
dme00740  Riboflavin metabolism
dme00790  Folate biosynthesis
KO pathway
ko00230   

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