KEGG   PATHWAY: dro04972
Entry
dro04972                    Pathway                                
Name
Pancreatic secretion - Desmodus rotundus (common vampire bat)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
dro04972  Pancreatic secretion
dro04972

Other DBs
GO: 0030157
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112296275  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
112296774  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112297750  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112298360  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112298654  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
112298992  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112298993  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112299008  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112299171  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
112299258  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
112299415  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112299499  [KO:K01346] [EC:3.4.21.71]
112299561  [KO:K01345] [EC:3.4.21.70]
112299660  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112299887  CPA2; carboxypeptidase A2 isoform X1 [KO:K01298] [EC:3.4.17.15]
112299888  CPA1; carboxypeptidase A1 [KO:K08779] [EC:3.4.17.1]
112299912  PRSS2; LOW QUALITY PROTEIN: trypsin-2 [KO:K01312] [EC:3.4.21.4]
112300186  PNLIPRP1; inactive pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
112300188  PNLIP; LOW QUALITY PROTEIN: pancreatic triacylglycerol lipase [KO:K14073] [EC:3.1.1.3]
112300190  PNLIPRP2; pancreatic lipase-related protein 2 [KO:K14075] [EC:3.1.1.3]
112300359  [KO:K04634]
112300407  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
112300586  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112300682  CTRB1; chymotrypsinogen B isoform X1 [KO:K01310] [EC:3.4.21.1]
112300813  CTRL; LOW QUALITY PROTEIN: chymotrypsin-like protease CTRL-1 [KO:K09632] [EC:3.4.21.-]
112300968  CPA3; mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
112300986  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
112300993  TRPC1; short transient receptor potential channel 1 [KO:K04964]
112301115  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112301133  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
112301457  RAB3D; ras-related protein Rab-3D [KO:K07884]
112301792  SLC26A3; chloride anion exchanger [KO:K14078]
112302101  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112303826  [KO:K04632]
112303827  [KO:K04632]
112304122  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304255  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304763  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112305194  RAB8A; ras-related protein Rab-8A [KO:K07901]
112305294  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
112305509  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
112305954  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
112306096  RYR2; ryanodine receptor 2 [KO:K04962]
112306553  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
112306844  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112307557  [KO:K04513]
112308281  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
112308396  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112308526  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
112309140  CLCA2; LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 2 [KO:K05028]
112309141  CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030]
112309142  [KO:K05030]
112309183  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
112309492  RHOA; transforming protein RhoA [KO:K04513]
112309625  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
112309989  CCK; cholecystokinin [KO:K05226]
112310342  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112310516  PLA2G3; LOW QUALITY PROTEIN: group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112310624  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112310676  CPB2; carboxypeptidase B2 isoform X1 [KO:K01300] [EC:3.4.17.20]
112310823  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
112311234  RAB11A; ras-related protein Rab-11A [KO:K07904]
112311437  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112313047  SCTR; secretin receptor [KO:K04588]
112313523  [KO:K01176] [EC:3.2.1.1]
112313714  RAP1A; ras-related protein Rap-1A [KO:K04353]
112313776  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
112314310  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
112314689  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
112314788  [KO:K01047] [EC:3.1.1.4]
112314975  SLC12A2; LOW QUALITY PROTEIN: solute carrier family 12 member 2 [KO:K10951]
112315487  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112315807  [KO:K01539] [EC:7.2.2.13]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112316691  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
112316692  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
112316868  CCKAR; cholecystokinin receptor type A [KO:K04194]
112317151  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112317329  TPCN2; two pore calcium channel protein 2 [KO:K14077]
112317429  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
112317734  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
112317852  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
112318382  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112318673  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
112318977  RAP1B; ras-related protein Rap-1b [KO:K07836]
112319549  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112320186  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
112320488  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112320764  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
112321008  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112321262  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112321412  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112322038  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575]
112322661  RAB27B; ras-related protein Rab-27B [KO:K07886]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
dro04020  Calcium signaling pathway
dro04530  Tight junction
dro04973  Carbohydrate digestion and absorption
dro04974  Protein digestion and absorption
dro04975  Fat digestion and absorption
dro04977  Vitamin digestion and absorption
KO pathway
ko04972   

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