KEGG   PATHWAY: eee04150
Entry
eee04150                    Pathway                                
Name
mTOR signaling pathway - Electrophorus electricus (electric eel)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
eee04150  mTOR signaling pathway
eee04150

Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113590208  slc7a5; LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 1 [KO:K13780]
113586009  4F2 cell-surface antigen heavy chain-like [KO:K06519]
113579831  4F2 cell-surface antigen heavy chain-like [KO:K06519]
113576778  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
113576113  atp6v1a; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
113570270  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
113586456  V-type proton ATPase subunit B, brain isoform [KO:K02147]
113576338  V-type proton ATPase subunit B, brain isoform [KO:K02147]
113580040  atp6v1c1; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 1 [KO:K02148]
113580828  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
113586258  V-type proton ATPase subunit E 1-like [KO:K02150]
113589250  V-type proton ATPase subunit E 1-like [KO:K02150]
113579976  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
113572462  V-type proton ATPase subunit G 1-like [KO:K02152]
113589420  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
113578731  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
113580007  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
113585844  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
113579987  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
113567501  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
113570667  flcn; folliculin [KO:K09594]
113578025  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
113586466  folliculin-interacting protein 2-like isoform X1 [KO:K20401]
113574170  ras-related GTP-binding protein A [KO:K16185]
113590643  ras-related GTP-binding protein D-like isoform X1 [KO:K16186]
113590870  ras-related GTP-binding protein C-like isoform X1 [KO:K16186]
113572219  rragc; ras-related GTP-binding protein C [KO:K16186]
113588361  sestrin-2-like isoform X1 [KO:K20394]
113577754  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
113573778  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
113567838  mios; GATOR complex protein MIOS isoform X1 [KO:K20407]
113585427  seh1l; nucleoporin SEH1 [KO:K14299]
113586584  wdr24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
113570871  wdr59; GATOR complex protein WDR59 [KO:K20409]
113583732  sec13; protein SEC13 homolog [KO:K14004]
113575131  depdc5; LOW QUALITY PROTEIN: GATOR complex protein DEPDC5 [KO:K20404]
113569228  nprl2; GATOR complex protein NPRL2 [KO:K20405]
113590706  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
113574196  skp2; S-phase kinase-associated protein 2 [KO:K03875]
113571975  rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
113578854  rptor; regulatory-associated protein of mTOR [KO:K07204]
113587138  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
113584326  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113572368  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
113570591  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
113574859  mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
113579384  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
113582357  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
113583741  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
113576913  clip1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
113589114  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
113586566  grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
113568114  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
113569658  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
113580120  lpin2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
113579854  lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
113584871  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
113573444  ulk1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
113569687  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
113587405  eukaryotic translation initiation factor 4E-1B isoform X1 [KO:K03259]
113591597  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
113589674  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
113585797  eukaryotic translation initiation factor 4E-like [KO:K03259]
113592188  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
113568457  eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
113584368  rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
113568160  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
113567992  eukaryotic translation initiation factor 4B-like [KO:K03258]
113582250  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
113585876  rps6; 40S ribosomal protein S6 [KO:K02991]
113569802  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
113570312  STE20-related kinase adapter protein beta-like isoform X1 [KO:K17532]
113582890  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
113577484  calcium-binding protein 39-like [KO:K08272]
113579241  calcium-binding protein 39-like [KO:K08272]
113591507  cab39; calcium-binding protein 39 [KO:K08272]
113589709  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
113570222  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
113573747  tsc1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
113577927  hamartin-like [KO:K07206]
113591344  tsc2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
113571852  TBC1 domain family member 7-like [KO:K20396]
113574246  GTP-binding protein Rheb-like [KO:K07208]
113572666  rheb; GTP-binding protein Rheb [KO:K07208]
113580945  DNA damage-inducible transcript 4 protein-like [KO:K08270]
113572807  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
113584444  wnt1; proto-oncogene Wnt-1 [KO:K03209]
113572035  wnt2b; protein Wnt-2b [KO:K00182]
113573613  wnt2; protein Wnt-2 [KO:K00182]
113583078  protein Wnt-2b-A-like [KO:K00182]
113584183  wnt3; proto-oncogene Wnt-3 [KO:K00312]
113587155  wnt3a; protein Wnt-3a [KO:K00312]
113574764  protein Wnt-4-like [KO:K00408]
113586658  wnt4; protein Wnt-4 [KO:K00408]
113578891  protein Wnt-5a-like [KO:K00444]
113584605  protein Wnt-5b isoform X1 [KO:K00444]
113591172  wnt6; protein Wnt-6 [KO:K00445]
113574053  protein Wnt-6-like [KO:K00445]
113583647  protein Wnt-7b [KO:K00572]
113572548  wnt7b; protein Wnt-7b [KO:K00572]
113586314  LOW QUALITY PROTEIN: protein Wnt-7a-like [KO:K00572]
113572305  wnt7a; protein Wnt-7a [KO:K00572]
113580952  protein Wnt-8b [KO:K00714]
113587179  protein Wnt-8c-like [KO:K00714]
113587180  protein Wnt-8a-like [KO:K00714]
113590801  wnt9a; protein Wnt-9a [KO:K01064]
113589912  protein Wnt-9b-like [KO:K01064]
113584450  wnt10b; protein Wnt-10b [KO:K01357]
113591173  wnt10a; protein Wnt-10a [KO:K01357]
113592140  protein Wnt-11-like [KO:K01384]
113590921  protein Wnt-11-like [KO:K01384]
113582698  wnt16; protein Wnt-16 [KO:K01558]
113571960  frizzled-1-like [KO:K02432]
113578539  frizzled-7-A-like [KO:K02432]
113584091  fzd7; frizzled-7 isoform X1 [KO:K02432]
113580237  fzd2; frizzled-2 [KO:K02235]
113578590  frizzled-3-like isoform X1 [KO:K02329]
113581029  frizzled-3-like isoform X1 [KO:K02329]
113588550  fzd4; frizzled-4 [KO:K02354]
113589849  fzd8; frizzled-8 [KO:K02375]
113576052  fzd6; frizzled-6 [KO:K02376]
113577450  fzd9; frizzled-9 [KO:K02842]
113584870  fzd10; frizzled-10 [KO:K02842]
113567826  frizzled-9-like [KO:K02842]
113567556  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
113586256  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
113581283  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
113567687  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
113570143  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
113578914  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
113576957  dvl3; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
113578561  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113586401  tumor necrosis factor-like [KO:K03156]
113575300  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113569968  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113584916  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113591428  ins; insulin [KO:K04526]
113584584  igf1; insulin-like growth factor I [KO:K05459]
113584152  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
113573593  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113586501  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113575233  growth factor receptor-bound protein 2 [KO:K04364]
113584789  growth factor receptor-bound protein 2-like [KO:K04364]
113577720  son of sevenless homolog 2-like isoform X1 [KO:K03099]
113578009  sos1; son of sevenless homolog 1 [KO:K03099]
113579694  GTPase HRas [KO:K02833]
113581312  hras; GTPase HRas [KO:K02833]
113588524  GTPase KRas isoform X1 [KO:K07827]
113589852  GTPase HRas-like [KO:K07827]
113577375  nras; GTPase NRas [KO:K07828]
113572532  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113580611  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
113572287  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
113588584  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113588939  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113584672  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113585589  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
113592047  mitogen-activated protein kinase 1-like isoform X1 [KO:K04371] [EC:2.7.11.24]
113570189  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
113591136  ribosomal protein S6 kinase 2 alpha-like [KO:K04373] [EC:2.7.11.1]
113573862  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
113574176  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
113585479  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
113591002  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
113588983  irs1; insulin receptor substrate 1 [KO:K16172]
113567981  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113587165  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
113588232  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113568728  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113584997  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113581289  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
113590406  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113579468  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113573804  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
113578461  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
113571342  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113578378  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113568414  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113579639  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113582078  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113590370  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
113573710  rictor; rapamycin-insensitive companion of mTOR [KO:K08267]
113585493  proline-rich protein 5-like isoform X1 [KO:K20411]
113579769  proline-rich protein 5-like [KO:K20411]
113582566  prr5l; proline-rich protein 5-like isoform X1 [KO:K20411]
113575836  rho-related GTP-binding protein RhoA-B [KO:K04513]
113582797  transforming protein RhoA-like [KO:K04513]
113587089  rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
113587285  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
113583072  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
113572085  rho-related GTP-binding protein RhoA-D [KO:K04513]
113575317  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
113590761  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113588773  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
113580901  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113571961  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
113582925  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
113591530  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
eee00561  Glycerolipid metabolism
eee04010  MAPK signaling pathway
eee04140  Autophagy - animal
eee04810  Regulation of actin cytoskeleton
eee04910  Insulin signaling pathway
KO pathway
ko04150   
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