KEGG   PATHWAY: eee04010
Entry
eee04010                    Pathway                                
Name
MAPK signaling pathway - Electrophorus electricus (electric eel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
eee04010  MAPK signaling pathway
eee04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113567547  [KO:K05462]
113567548  [KO:K05462]
113567934  [KO:K04380]
113568055  [KO:K04344]
113568060  mecom; MDS1 and EVI1 complex locus protein [KO:K04462] [EC:2.1.1.367]
113568131  [KO:K05462]
113568152  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
113568294  [KO:K03283]
113568362  [KO:K04358]
113568414  [KO:K04456] [EC:2.7.11.1]
113568537  [KO:K04864]
113568547  [KO:K05462]
113568701  [KO:K04448]
113569106  nrtn; neurturin [KO:K25414]
113569275  [KO:K04460] [EC:3.1.3.16]
113569758  [KO:K04429] [EC:2.7.11.1]
113569771  [KO:K04438]
113569804  [KO:K04869]
113569810  [KO:K04866]
113569825  [KO:K04429] [EC:2.7.11.1]
113569912  ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
113569914  [KO:K04468] [EC:2.7.11.24]
113569968  [KO:K03158]
113570037  [KO:K04437]
113570159  [KO:K04453]
113570174  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
113570189  [KO:K04373] [EC:2.7.11.1]
113570630  [KO:K04873]
113570633  [KO:K04872]
113570637  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
113570683  [KO:K02583]
113570740  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
113570756  crkl; crk-like protein [KO:K04438]
113570786  fgf10; fibroblast growth factor 10 [KO:K04358]
113570943  [KO:K04430] [EC:2.7.12.2]
113571041  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
113571058  efna5; ephrin-A5 [KO:K05462]
113571260  [KO:K04440] [EC:2.7.11.24]
113571264  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113571342  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113571483  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
113571530  [KO:K17534] [EC:2.7.11.25]
113571596  [KO:K04859]
113571777  [KO:K05466]
113571874  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113571898  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
113572077  rap1a; ras-related protein Rap-1A [KO:K04353]
113572170  [KO:K04381]
113572191  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
113572229  [KO:K04426] [EC:2.7.11.25]
113572287  [KO:K04366] [EC:2.7.11.1]
113572343  [KO:K04348] [EC:3.1.3.16]
113572528  rap1b; ras-related protein Rap-1b [KO:K07836]
113572532  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113572578  [KO:K05462]
113572585  [KO:K04393]
113572627  [KO:K05462]
113572791  [KO:K04461] [EC:3.1.3.16]
113572852  [KO:K04856]
113572862  [KO:K07860]
113572895  rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
113572902  mef2c; LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2C [KO:K04454]
113572972  [KO:K04457] [EC:3.1.3.16]
113573155  [KO:K17333]
113573338  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
113573427  [KO:K04849]
113573593  [KO:K05087] [EC:2.7.10.1]
113573801  [KO:K13375]
113573843  [KO:K04377]
113573862  [KO:K04373] [EC:2.7.11.1]
113573874  [KO:K05096] [EC:2.7.10.1]
113573982  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
113574052  [KO:K04865]
113574092  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
113574116  [KO:K04457] [EC:3.1.3.16]
113574122  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
113574176  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
113574218  [KO:K04411]
113574264  [KO:K07861]
113574265  [KO:K04440] [EC:2.7.11.24]
113574672  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
113574678  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
113574890  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
113574960  [KO:K12326]
113575026  stk3; serine/threonine-protein kinase 3 [KO:K04412]
113575099  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
113575198  [KO:K04347]
113575233  [KO:K04364]
113575300  [KO:K03158]
113575309  [KO:K04392]
113575317  [KO:K02677] [EC:2.7.11.13]
113575356  [KO:K04441] [EC:2.7.11.24]
113575357  [KO:K04441] [EC:2.7.11.24]
113575385  [KO:K04407] [EC:2.7.11.1]
113575388  [KO:K04386]
113575429  [KO:K04372] [EC:2.7.11.1]
113575458  [KO:K04393]
113575551  csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
113575581  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113575586  [KO:K04358]
113575754  rras2; ras-related protein R-Ras2 [KO:K07830]
113575795  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
113575834  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
113575949  [KO:K08774]
113576088  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113576161  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
113576222  fgf22; fibroblast growth factor 22 [KO:K04358]
113576292  [KO:K04872]
113576294  [KO:K04873]
113576367  [KO:K04410] [EC:2.7.11.1]
113576377  [KO:K04441] [EC:2.7.11.24]
113576463  [KO:K05462]
113576525  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
113576529  [KO:K21278] [EC:3.1.3.16 3.1.3.48]
113576556  [KO:K04850]
113576576  [KO:K04861]
113576712  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
113576764  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
113576794  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113576818  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
113576854  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
113576858  [KO:K02583]
113576959  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113577153  [KO:K04358]
113577168  [KO:K05460]
113577182  [KO:K04858]
113577239  [KO:K04381]
113577270  [KO:K04423] [EC:2.7.11.25]
113577345  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113577352  [KO:K04451]
113577375  nras; GTPase NRas [KO:K07828]
113577382  [KO:K04441] [EC:2.7.11.24]
113577546  hspb1; heat shock protein beta-1 [KO:K04455]
113577684  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
113577702  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
113577720  [KO:K03099]
113577848  fgf4; fibroblast growth factor 4 [KO:K04358]
113577940  [KO:K04849]
113577947  [KO:K03173] [EC:2.3.2.27]
113577953  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
113577966  [KO:K05103] [EC:2.7.10.1]
113577967  fgf3; fibroblast growth factor 3 [KO:K04358]
113578009  sos1; son of sevenless homolog 1 [KO:K03099]
113578011  ddit3; LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein [KO:K04452]
113578033  [KO:K04440] [EC:2.7.11.24]
113578087  [KO:K04358]
113578091  fgf23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
113578092  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
113578240  vegfd; vascular endothelial growth factor D [KO:K05449]
113578371  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
113578378  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113578453  [KO:K03283]
113578705  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
113578747  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
113578767  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113578783  [KO:K04443] [EC:2.7.11.1]
113578786  fgf19; fibroblast growth factor 19 [KO:K22603]
113578872  [KO:K04402]
113578873  [KO:K04402]
113578875  [KO:K05462]
113578882  [KO:K04860]
113578945  [KO:K04423] [EC:2.7.11.25]
113578974  [KO:K05448]
113579053  map3k10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
113579098  [KO:K04853]
113579129  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113579151  [KO:K04860]
113579158  [KO:K04851]
113579161  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
113579187  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
113579192  [KO:K05085] [EC:2.7.10.1]
113579240  fgf20; fibroblast growth factor 20 [KO:K04358]
113579280  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
113579372  [KO:K04410] [EC:2.7.11.1]
113579485  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113579639  [KO:K04456] [EC:2.7.11.1]
113579658  [KO:K06268]
113579694  [KO:K02833]
113579696  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113579707  [KO:K13769]
113579727  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
113579845  [KO:K04350]
113579858  [KO:K04453]
113579862  [KO:K04402]
113579878  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
113579942  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
113580060  [KO:K04852]
113580065  [KO:K04424] [EC:2.7.11.25]
113580169  epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
113580171  [KO:K04863]
113580207  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
113580221  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
113580228  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
113580273  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113580274  rras; ras-related protein R-Ras [KO:K07830]
113580284  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113580323  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
113580330  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113580342  [KO:K04856]
113580350  [KO:K04386]
113580442  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
113580519  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
113580561  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113580611  [KO:K04366] [EC:2.7.11.1]
113580677  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113580797  [KO:K04439]
113580846  [KO:K03283]
113580901  [KO:K19662] [EC:2.7.11.13]
113580910  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
113580979  ntf3; neurotrophin-3 [KO:K04356]
113581016  gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
113581084  [KO:K04857]
113581205  [KO:K04421] [EC:2.7.11.25]
113581255  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
113581312  hras; GTPase HRas [KO:K02833]
113581376  [KO:K05084] [EC:2.7.10.1]
113581424  map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
113581460  [KO:K04358]
113581478  [KO:K07831]
113581482  [KO:K25416]
113581484  [KO:K04359]
113581517  casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113581523  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
113581542  erbb3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
113581676  [KO:K13376]
113581708  [KO:K04446]
113581750  [KO:K04348] [EC:3.1.3.16]
113581790  [KO:K04434]
113581810  [KO:K04414] [EC:2.7.11.1]
113581832  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
113581910  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113582000  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113582024  vegfc; vascular endothelial growth factor C [KO:K05449]
113582078  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113582116  [KO:K04438]
113582128  [KO:K16510] [EC:2.7.11.1]
113582188  [KO:K04867]
113582331  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113582430  pdgfc; platelet-derived growth factor C [KO:K05450]
113582440  [KO:K05096] [EC:2.7.10.1]
113582828  tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
113582834  [KO:K04448]
113582951  [KO:K04429] [EC:2.7.11.1]
113583119  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
113583131  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
113583190  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
113583212  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
113583215  [KO:K04454]
113583287  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
113583341  kitlg; kit ligand isoform X1 [KO:K05461]
113583627  [KO:K04455]
113583646  [KO:K04429] [EC:2.7.11.1]
113583770  [KO:K04466] [EC:2.7.11.25]
113583820  [KO:K04859]
113584063  [KO:K04519]
113584100  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
113584152  [KO:K04527] [EC:2.7.10.1]
113584174  [KO:K04439]
113584194  [KO:K04735]
113584203  srf; LOW QUALITY PROTEIN: serum response factor [KO:K04378]
113584383  [KO:K12326]
113584395  [KO:K05461]
113584523  [KO:K08052]
113584584  igf1; insulin-like growth factor I [KO:K05459]
113584625  [KO:K04392]
113584672  [KO:K04369] [EC:2.7.12.2]
113584789  [KO:K04364]
113584916  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113584941  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
113584976  [KO:K04358]
113584980  [KO:K05099] [EC:2.7.10.1]
113584985  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
113585082  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113585128  [KO:K16342] [EC:3.1.1.4]
113585232  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
113585260  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
113585352  fgf7; fibroblast growth factor 7 [KO:K04358]
113585459  [KO:K04358]
113585479  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
113585519  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113585541  [KO:K04441] [EC:2.7.11.24]
113585589  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
113585612  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
113585643  [KO:K04433] [EC:2.7.12.2]
113585737  [KO:K17386]
113585758  [KO:K04414] [EC:2.7.11.1]
113585820  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
113585844  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
113585922  [KO:K04379]
113585931  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
113585960  jund; transcription factor jun-D [KO:K04449]
113586036  angpt2; angiopoietin-2 [KO:K05466]
113586062  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
113586113  [KO:K08018]
113586186  [KO:K04441] [EC:2.7.11.24]
113586200  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
113586255  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113586292  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
113586306  [KO:K04440] [EC:2.7.11.24]
113586321  [KO:K04468] [EC:2.7.11.24]
113586382  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113586383  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
113586384  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
113586401  [KO:K03156]
113586429  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
113586434  [KO:K04861]
113586457  [KO:K16342] [EC:3.1.1.4]
113586501  [KO:K05087] [EC:2.7.10.1]
113586523  [KO:K04353]
113586537  [KO:K02187] [EC:3.4.22.56]
113586627  [KO:K25415]
113586656  [KO:K04393]
113586749  [KO:K04344]
113586931  [KO:K04360] [EC:2.7.10.1]
113586976  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
113587029  [KO:K16859]
113587260  [KO:K04465]
113587279  [KO:K13769]
113587328  [KO:K17333]
113587421  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
113587446  [KO:K05090] [EC:2.7.10.1]
113587612  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
113587808  [KO:K02582]
113587836  [KO:K04380]
113587857  [KO:K04345] [EC:2.7.11.11]
113587946  [KO:K04361] [EC:2.7.10.1]
113587986  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113588015  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113588019  angpt1; angiopoietin-1 [KO:K05465]
113588037  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113588078  [KO:K03173] [EC:2.3.2.27]
113588109  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
113588173  [KO:K04362] [EC:2.7.10.1]
113588284  [KO:K05460]
113588287  [KO:K04858]
113588416  [KO:K04358]
113588458  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
113588459  [KO:K04372] [EC:2.7.11.1]
113588524  [KO:K07827]
113588549  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
113588584  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113588627  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
113588638  [KO:K16342] [EC:3.1.1.4]
113588681  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113588695  [KO:K04465]
113588773  [KO:K19662] [EC:2.7.11.13]
113588923  [KO:K16342] [EC:3.1.1.4]
113588939  [KO:K04369] [EC:2.7.12.2]
113589038  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113589084  [KO:K05453]
113589104  [KO:K04389]
113589106  [KO:K04448]
113589172  [KO:K22429]
113589212  [KO:K04852]
113589328  [KO:K04347]
113589335  [KO:K04402]
113589363  fgf2; fibroblast growth factor 2 [KO:K18497]
113589385  [KO:K04424] [EC:2.7.11.25]
113589387  fgf16; fibroblast growth factor 16 [KO:K04358]
113589460  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
113589461  [KO:K16342] [EC:3.1.1.4]
113589508  [KO:K13769]
113589577  [KO:K04348] [EC:3.1.3.16]
113589588  [KO:K04350]
113589593  [KO:K02582]
113589671  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
113589755  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
113589809  [KO:K04407] [EC:2.7.11.1]
113589813  [KO:K04348] [EC:3.1.3.16]
113589820  [KO:K04377]
113589852  [KO:K07827]
113589856  fgf5; fibroblast growth factor 5 [KO:K04358]
113589915  [KO:K04466] [EC:2.7.11.25]
113589932  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
113590096  [KO:K04441] [EC:2.7.11.24]
113590125  [KO:K04379]
113590136  [KO:K04379]
113590165  [KO:K08052]
113590405  [KO:K04390]
113590490  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
113590492  [KO:K13375]
113590517  [KO:K04358]
113590604  [KO:K04388] [EC:2.7.11.30]
113590621  [KO:K04358]
113590741  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
113590756  [KO:K04868]
113590761  [KO:K19662] [EC:2.7.11.13]
113590807  [KO:K04402]
113590829  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
113590834  [KO:K04869]
113590835  [KO:K04866]
113590856  [KO:K04347]
113591136  [KO:K04373] [EC:2.7.11.1]
113591278  [KO:K04345] [EC:2.7.11.11]
113591405  [KO:K04430] [EC:2.7.12.2]
113591428  ins; insulin [KO:K04526]
113591465  [KO:K25415]
113591515  [KO:K04388] [EC:2.7.11.30]
113591517  [KO:K04388] [EC:2.7.11.30]
113591558  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
113591595  [KO:K05091] [EC:2.7.10.1]
113591692  [KO:K04865]
113591719  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
113591752  relb; transcription factor RelB isoform X1 [KO:K09253]
113591863  mapkapk3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
113591899  [KO:K04419] [EC:2.7.11.25]
113591949  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
113592026  [KO:K04345] [EC:2.7.11.11]
113592047  [KO:K04371] [EC:2.7.11.24]
113592099  mras; ras-related protein M-Ras isoform X1 [KO:K07831]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
eee04070  Phosphatidylinositol signaling system
eee04110  Cell cycle
eee04115  p53 signaling pathway
eee04210  Apoptosis
eee04310  Wnt signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system