KEGG   PATHWAY: hgl00590
Entry
hgl00590                    Pathway                                
Name
Arachidonic acid metabolism - Heterocephalus glaber (naked mole-rat)
Class
Metabolism; Lipid metabolism
Pathway map
hgl00590  Arachidonic acid metabolism
hgl00590

Other DBs
GO: 0019369
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101708051  Pla2g3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
101699902  Pla2g1b; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
101696546  Pla2g10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
101702299  Pla2g12b; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
101711308  Pla2g5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
101725417  Pla2g2e; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
101725805  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101726523  Pla2g2f; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
101696389  Pla2g2c; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
101710939  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101711672  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101706727  Pla2g12a; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
101705849  Pla2g4e; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
101706202  Pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
101703792  Pla2g4b; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
101717491  Pla2g4d; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
101713091  Pla2g4c; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
101704061  Pla2g4a; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
101710669  Pla2g6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
101699397  Plb1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101712273  Pla2g16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101713128  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101698854  Ptgs1; prostaglandin-endoperoxide synthase 1 [KO:K00509] [EC:1.14.99.1]
101704771  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
101703245  Ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
101712155  Ptges2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
101701326  Ptges3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
101709698  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101707305  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101726221  carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
101697950  Cbr3; carbonyl reductase 3 [KO:K00084] [EC:1.1.1.184]
101722975  Fam213b; family with sequence similarity 213 member B [KO:K15717] [EC:1.11.1.20]
101714528  Hpgd; hydroxyprostaglandin dehydrogenase 15-(NAD) [KO:K00069] [EC:1.1.1.141]
101697368  Tbxas1; thromboxane A synthase 1 [KO:K01832] [EC:5.3.99.5]
101699559  Ptgds; prostaglandin D2 synthase [KO:K01830] [EC:5.3.99.2]
101706734  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
101702106  aldo-keto reductase family 1 member C23-like protein [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101700601  Ptgis; prostaglandin I2 synthase [KO:K01831] [EC:5.3.99.4]
101700210  Alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101700383  Lta4h; leukotriene A4 hydrolase [KO:K01254] [EC:3.3.2.6]
101706941  Zadh2; zinc binding alcohol dehydrogenase domain containing 2 [KO:K07119] [EC:1.3.1.48]
101708944  Ptgr2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
101699930  Ptgr1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
101722474  Ltc4s; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
101722156  Ggt1; gamma-glutamyltransferase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101723554  Ggt5; gamma-glutamyltransferase 5 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101708875  Gpx4; glutathione peroxidase 4 [KO:K05361] [EC:1.11.1.12]
101722366  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101719021  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101719368  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101708291  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
101696405  cytochrome P450 4A4-like [KO:K07425] [EC:1.14.14.80]
101699948  cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
101700306  cytochrome P450 4A4-like [KO:K07425] [EC:1.14.14.80]
101702123  Alox12; arachidonate 12-lipoxygenase, 12S type [KO:K00458] [EC:1.13.11.31]
101709560  Aloxe3; arachidonate lipoxygenase 3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
101708945  Alox12b; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
101698545  arachidonate 15-lipoxygenase B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101713256  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
101700457  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
101708592  cytochrome P450 2C55 [KO:K07413] [EC:1.14.14.1]
101710990  cytochrome P450 2C5 [KO:K07413] [EC:1.14.14.1]
101715352  Ephx2; epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
hgl00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

DBGET integrated database retrieval system