Entry Name mTOR signaling pathway - Hippoglossus hippoglossus (Atlantic halibut)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Hippoglossus hippoglossus (Atlantic halibut) [GN:
hhip ]
Gene 117752039 si:ch73-335l21.1; LOW QUALITY PROTEIN: insulin receptor substrate 1-B [KO:K16172 ]
117752050 dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
117752607 telo2; telomere length regulation protein TEL2 homolog [KO:K11137 ]
117756430 lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370 ]
117756630 eif4eb; eukaryotic translation initiation factor 4eb isoform X1 [KO:K03259 ]
117759311 wdr59; LOW QUALITY PROTEIN: GATOR complex protein WDR59 [KO:K20409 ]
117760130 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
117761090 si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
117761742 wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572 ]
117762744 lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
117763421 slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
117764692 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
117766449 grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364 ]
117766816 strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
117767951 rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
117768190 castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080 ]
117768291 clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
117771255 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
117771286 clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
117771417 slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995 ]
117771910 mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410 ]
117772752 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
117773867 castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081 ]
117775103 eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259 ]
117775424 atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
117776721 grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064 ]
117776812 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
117776813 wnt4b; wingless-type MMTV integration site family, member 4b isoform X1 [KO:K00408 ]
117777355 deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402 ]
117777997 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
117778066 eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
117779227 zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
117779240 eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related KO pathway
