Entry Name B cell receptor signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map iti04662 B cell receptor signaling pathway
Other DBs Organism Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:
iti ]
Gene 101956154 Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II-b isoform X2 [KO:K12560 ]
101956975 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
101958429 Vav2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730 ]
101958717 Cd79a; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
101962360 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101964684 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101965203 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
101967440 Card11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
101970348 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8 [KO:K04348 ] [EC:3.1.3.16 ]
101970750 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101971784 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2 [KO:K07369 ] [EC:3.4.22.-]
101972573 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580 ]
101972903 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
101973345 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101974764 Cd79b; B-cell antigen receptor complex-associated protein beta chain [KO:K06507 ]
101975512 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101975690 Dapp1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
101976353 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101977694 Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730 ]
101978230 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related iti04610 Complement and coagulation cascades
iti04810 Regulation of actin cytoskeleton
KO pathway
