KEGG   PATHWAY: iti04151
Entry
iti04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
iti04151  PI3K-Akt signaling pathway
iti04151

Other DBs
GO: 0043491
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954294  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2 [KO:K16340] [EC:3.1.3.16]
101954451  Bdnf; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101954454  Epo; erythropoietin [KO:K05437]
101954478  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
101954537  Col4a3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101954599  Ywhah; 14-3-3 protein eta isoform X2 [KO:K16198]
101954667  Fgf18; fibroblast growth factor 18 [KO:K04358]
101954727  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
101954822  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
101954847  [KO:K04545]
101954979  [KO:K06253]
101955096  Itgb8; integrin beta-8 isoform X2 [KO:K06591]
101955098  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101955124  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101955133  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
101955169  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
101955252  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101955264  Ikbkg; NF-kappa-B essential modulator isoform X5 [KO:K07210]
101955315  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101955316  Rela; transcription factor p65 [KO:K04735]
101955352  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
101955384  Vegfc; vascular endothelial growth factor C [KO:K05449]
101955392  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101955522  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101955606  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101955693  Col1a2; collagen alpha-2(I) chain [KO:K06236]
101955790  [KO:K16197]
101955806  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101955809  [KO:K05096] [EC:2.7.10.1]
101955970  Ghr; growth hormone receptor [KO:K05080]
101955981  Il6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
101956019  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
101956042  Reln; reelin [KO:K06249] [EC:3.4.21.-]
101956072  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101956164  Cd19; B-lymphocyte antigen CD19 [KO:K06465]
101956286  Nrtn; neurturin [KO:K25414]
101956319  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101956398  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101956589  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
101956689  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101956739  [KO:K05439]
101956748  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
101956834  Brca1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
101956917  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101957086  Myc; myc proto-oncogene protein [KO:K04377]
101957141  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
101957209  Kit; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101957220  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101957333  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101957392  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101957398  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101957564  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
101957629  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101957631  F2r; proteinase-activated receptor 1 [KO:K03914]
101957648  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101957687  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101957738  Tp53; cellular tumor antigen p53 [KO:K04451]
101957833  Fgf20; fibroblast growth factor 20 [KO:K04358]
101957870  Bcl2l11; bcl-2-like protein 11 isoform X4 [KO:K16341]
101957872  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101957921  Foxo3; forkhead box protein O3 [KO:K09408]
101958021  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X2 [KO:K21290]
101958100  Itga4; integrin alpha-4 [KO:K06483]
101958117  Ccne1; G1/S-specific cyclin-E1 isoform X2 [KO:K06626]
101958119  [KO:K04374]
101958546  Ppp2cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101958576  Osmr; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
101958580  Rheb; GTP-binding protein Rheb isoform X1 [KO:K07208]
101958591  [KO:K04659]
101958723  Pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
101958728  Tnr; tenascin-R isoform X1 [KO:K06252]
101958853  [KO:K04358]
101959071  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
101959193  Artn; artemin [KO:K25415]
101959298  Tnn; tenascin-N isoform X1 [KO:K06252]
101959359  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
101959389  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
101959440  Pspn; persephin [KO:K25416]
101959459  Itgb6; integrin beta-6 isoform X2 [KO:K06589]
101959612  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
101959615  Il4r; interleukin-4 receptor subunit alpha [KO:K05071]
101959621  Gdnf; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
101959639  Il6r; interleukin-6 receptor subunit alpha [KO:K05055]
101959670  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101959820  Vtn; vitronectin isoform X1 [KO:K06251]
101959829  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
101959966  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
101959985  Hras; GTPase HRas isoform X2 [KO:K02833]
101959986  Chad; chondroadherin [KO:K06248]
101960094  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
101960134  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
101960211  Vegfb; vascular endothelial growth factor B [KO:K16858]
101960280  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
101960285  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
101960429  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101960481  Lama5; laminin subunit alpha-5 [KO:K06240]
101960598  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
101960709  Il3; interleukin-3 [KO:K04736]
101960744  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101960867  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101961072  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101961192  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101961209  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
101961238  Itgav; integrin alpha-V isoform X1 [KO:K06487]
101961479  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101961610  Pgf; placenta growth factor isoform X1 [KO:K16859]
101961621  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
101961679  Il2rg; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070]
101961798  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101961818  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
101961877  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
101961937  Vegfd; vascular endothelial growth factor D [KO:K05449]
101962025  Fgf4; fibroblast growth factor 4 [KO:K04358]
101962123  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
101962346  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X5 [KO:K06276] [EC:2.7.11.1]
101962360  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101962445  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584]
101962502  Areg; amphiregulin [KO:K09782]
101962660  [KO:K00922] [EC:2.7.1.153]
101962695  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101962705  [KO:K05631]
101962761  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
101962777  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101962780  Ereg; proepiregulin [KO:K09784]
101962827  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101962835  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
101962866  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
101962956  [KO:K06238]
101962971  Fn1; fibronectin isoform X1 [KO:K05717]
101963110  Tsc1; hamartin isoform X1 [KO:K07206]
101963124  Sos2; son of sevenless homolog 2 [KO:K03099]
101963135  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
101963235  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
101963242  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
101963246  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
101963400  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
101963459  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
101963523  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
101963540  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101963674  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101963701  Prlr; prolactin receptor [KO:K05081]
101963760  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101963776  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101963815  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
101963872  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101963921  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101963929  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101964114  Kras; GTPase KRas isoform X1 [KO:K07827]
101964126  Efna2; ephrin-A2 [KO:K05462]
101964196  Ywhag; 14-3-3 protein gamma [KO:K16198]
101964289  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101964304  Efna4; ephrin-A4 [KO:K05462]
101964329  Lama1; laminin subunit alpha-1 [KO:K05637]
101964364  Col1a1; collagen alpha-1(I) chain [KO:K06236]
101964440  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
101964481  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
101964484  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
101964547  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101964645  [KO:K04545]
101964672  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
101964684  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101964691  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101964766  Efna1; ephrin-A1 [KO:K05462]
101964768  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101964841  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
101965032  Mtcp1; protein p13 MTCP-1 [KO:K16837]
101965108  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101965194  Col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
101965246  [KO:K16197]
101965489  Mlst8; target of rapamycin complex subunit LST8 isoform X3 [KO:K08266]
101965569  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101965571  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101965688  Itga2; integrin alpha-2 [KO:K06481]
101965711  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101965740  Itgb3; integrin beta-3 [KO:K06493]
101965867  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101965906  [KO:K00922] [EC:2.7.1.153]
101965997  Lamc3; laminin subunit gamma-3 [KO:K06247]
101966090  Itga1; integrin alpha-1 [KO:K06480]
101966092  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101966158  Tcl1b; T-cell leukemia/lymphoma protein 1B [KO:K16836]
101966207  Ins; insulin precursor [KO:K04526]
101966263  Lama4; laminin subunit alpha-4 isoform X2 [KO:K06241]
101966264  Fgf16; fibroblast growth factor 16 [KO:K04358]
101966388  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
101966419  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101966453  Tcl1a; T-cell leukemia/lymphoma protein 1A [KO:K10167]
101966465  Rps6; 40S ribosomal protein S6 [KO:K02991]
101966469  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
101966501  Igf2; insulin-like growth factor II isoform X2 [KO:K13769]
101966565  Csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
101966712  Irs1; insulin receptor substrate 1 [KO:K16172]
101966765  Vwf; von Willebrand factor isoform X1 [KO:K03900]
101966876  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101966884  [KO:K03258]
101966934  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101966977  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101967013  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
101967025  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
101967027  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101967128  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
101967335  Ntf3; neurotrophin-3 [KO:K04356]
101967383  Itga5; integrin alpha-5 [KO:K06484]
101967417  Tsc2; tuberin isoform X1 [KO:K07207]
101967423  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
101967598  Fgf23; fibroblast growth factor 23 [KO:K22428]
101967608  Il2; interleukin-2 [KO:K05429]
101967614  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101967724  Lamc2; laminin subunit gamma-2 [KO:K06246]
101967745  Hsp90b1; endoplasmin [KO:K09487]
101967780  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
101967887  Fgf6; fibroblast growth factor 6 [KO:K04358]
101968002  Lamc1; laminin subunit gamma-1 [KO:K05635]
101968098  Fgf10; fibroblast growth factor 10 [KO:K04358]
101968159  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101968259  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101968271  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
101968287  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101968385  Il7; interleukin-7 [KO:K05431]
101968497  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
101968522  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101968576  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101968588  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101968688  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101968765  Ifnb1; interferon beta [KO:K05415]
101968856  Ntrk2; BDNF/NT-3 growth factors receptor isoform X4 [KO:K04360] [EC:2.7.10.1]
101968890  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
101968896  [KO:K00922] [EC:2.7.1.153]
101969021  [KO:K05438]
101969049  [KO:K05414]
101969116  Ywhaq; 14-3-3 protein theta [KO:K16197]
101969128  Tlr2; toll-like receptor 2 [KO:K10159]
101969226  Fgf3; fibroblast growth factor 3 [KO:K04358]
101969278  Tgfa; protransforming growth factor alpha isoform X2 [KO:K08774]
101969327  [KO:K05414]
101969397  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101969446  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101969458  Phlpp1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101969487  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
101969501  Fgf19; fibroblast growth factor 19 [KO:K22603]
101969789  Fgf22; fibroblast growth factor 22 isoform X3 [KO:K04358]
101969946  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
101969965  Col6a3; collagen alpha-3(VI) chain isoform X5 [KO:K06238]
101969979  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101969987  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101970097  [KO:K05414]
101970300  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101970320  Csf3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
101970392  [KO:K05414]
101970466  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101970499  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
101970616  Thbs2; thrombospondin-2 [KO:K04659]
101970679  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101970683  [KO:K05414]
101970700  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101970750  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101970758  Them4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
101970798  [KO:K04570]
101970818  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101970848  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
101970868  Itga9; integrin alpha-9 [KO:K06585]
101970891  Pkn3; serine/threonine-protein kinase N3 isoform X2 [KO:K23692]
101970905  [KO:K12457]
101971148  Pkn1; serine/threonine-protein kinase N1 isoform X7 [KO:K06071] [EC:2.7.11.13]
101971255  [KO:K05414]
101971364  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101971535  [KO:K05414]
101971676  [KO:K06643] [EC:2.3.2.27]
101971812  G6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
101971816  [KO:K06240]
101971818  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101971819  Lamb3; laminin subunit beta-3 [KO:K06244]
101971846  [KO:K05415]
101972098  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101972502  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101972525  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
101972573  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101972668  Kitlg; kit ligand isoform X1 [KO:K05461]
101972729  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101972732  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
101972847  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X4 [KO:K11584]
101972903  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101973034  Tnc; tenascin [KO:K06252]
101973035  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
101973091  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101973150  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
101973163  Egf; pro-epidermal growth factor [KO:K04357]
101973218  [KO:K02991]
101973662  Itga7; integrin alpha-7 isoform X7 [KO:K06583]
101973809  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
101973838  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101973855  Epor; erythropoietin receptor isoform X2 [KO:K05079]
101973874  [KO:K04570]
101973940  Angpt2; angiopoietin-2 [KO:K05466]
101974186  Sgk3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
101974269  Bcl2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101974316  [KO:K05414]
101974357  G6pc1; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
101974399  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
101974403  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
101974621  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101974705  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101974742  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
101974776  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101974952  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
101974985  Itgb5; integrin beta-5 [KO:K06588]
101975051  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101975090  [KO:K04354]
101975134  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101975152  [KO:K05415]
101975184  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101975221  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
101975227  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
101975241  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101975245  [KO:K04079]
101975259  Fgf7; fibroblast growth factor 7 [KO:K04358]
101975277  Lamb1; laminin subunit beta-1 [KO:K05636]
101975370  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101975401  Itgb7; integrin beta-7 isoform X2 [KO:K06590]
101975416  Prl; prolactin [KO:K05439]
101975434  [KO:K05415]
101975438  Fgf21; fibroblast growth factor 21 [KO:K22429]
101975529  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101975616  Stk11; serine/threonine-protein kinase STK11 isoform X5 [KO:K07298] [EC:2.7.11.1]
101975653  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
101975748  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101975791  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
101975819  Itga11; integrin alpha-11 [KO:K06587]
101975906  Nras; GTPase NRas [KO:K07828]
101975998  [KO:K05415]
101976082  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101976129  Angpt4; angiopoietin-4 isoform X2 [KO:K05467]
101976168  Itga2b; integrin alpha-IIb isoform X2 [KO:K06476]
101976174  Thbs4; thrombospondin-4 [KO:K04659]
101976233  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
101976283  [KO:K05414]
101976353  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101976372  Col9a1; collagen alpha-1(IX) chain [KO:K08131]
101976425  Osm; oncostatin-M [KO:K05418]
101976548  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101976552  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101976555  [KO:K04079]
101976957  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101977052  Fgf9; fibroblast growth factor 9 [KO:K04358]
101977091  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101977109  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
101977141  Tnxb; tenascin-X isoform X1 [KO:K06252]
101977233  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
101977249  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
101977282  Sgk2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
101977299  Itga8; integrin alpha-8 [KO:K06584]
101977479  Ngf; beta-nerve growth factor [KO:K02582]
101977507  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101977572  Efna3; ephrin-A3 [KO:K05462]
101977585  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101977662  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101977768  Cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101977828  Eif4e; eukaryotic translation initiation factor 4E isoform X3 [KO:K03259]
101977965  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101978133  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101978230  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101978245  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101978298  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101978392  Efna5; ephrin-A5 [KO:K05462]
101978429  Ntf4; neurotrophin-4 [KO:K12457]
101978449  Lamb4; laminin subunit beta-4 [KO:K06245]
101978468  Spp1; osteopontin isoform X1 [KO:K06250]
101978576  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
101978586  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101978587  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
106144716  [KO:K05450]
106145241  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
120889960  [KO:K02991]
120889971  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
120890343  Il3ra; interleukin-3 receptor subunit alpha [KO:K04737]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
iti00010  Glycolysis / Gluconeogenesis
iti04010  MAPK signaling pathway
iti04012  ErbB signaling pathway
iti04062  Chemokine signaling pathway
iti04064  NF-kappa B signaling pathway
iti04068  FoxO signaling pathway
iti04110  Cell cycle
iti04115  p53 signaling pathway
iti04150  mTOR signaling pathway
iti04210  Apoptosis
iti04370  VEGF signaling pathway
iti04510  Focal adhesion
iti04620  Toll-like receptor signaling pathway
iti04630  JAK-STAT signaling pathway
iti04662  B cell receptor signaling pathway
iti04910  Insulin signaling pathway
KO pathway
ko04151   

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