KEGG   PATHWAY: mcf04115
Entry
mcf04115                    Pathway                                
Name
p53 signaling pathway - Macaca fascicularis (crab-eating macaque)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
mcf04115  p53 signaling pathway
mcf04115

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101865074  SESN3; sestrin-3 isoform X1 [KO:K10141]
101865103  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101865354  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101865419  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
101865579  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
101865689  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
101865915  SESN1; sestrin-1 isoform X2 [KO:K10141]
101865999  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101866042  CCNG1; cyclin-G1 [KO:K10145]
101866059  SHISA5; protein shisa-5 isoform X3 [KO:K10135]
101866115  SESN2; sestrin-2 isoform X1 [KO:K20394]
101866991  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
101867036  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101925383  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
101925733  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101925942  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101926004  CHEK1; serine/threonine-protein kinase Chk1 isoform X3 [KO:K02216] [EC:2.7.11.1]
101926636  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101926839  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102115080  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102117102  [KO:K08738]
102118559  PPP1R13L; RelA-associated inhibitor [KO:K27356]
102119572  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102119825  BBC3; bcl-2-binding component 3 isoform X3 [KO:K10132]
102120192  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 isoform X2 [KO:K10131]
102120205  [KO:K08738]
102120315  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
102120841  [KO:K08738]
102122330  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
102122897  RPRM; protein reprimo [KO:K10128]
102122988  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
102123656  CCNG2; cyclin-G2 isoform X1 [KO:K10146]
102123704  [KO:K08738]
102124623  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
102124774  TP73; tumor protein p73 isoform X2 [KO:K10148]
102125088  [KO:K08738]
102126830  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102127614  [KO:K08738]
102128018  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
102128083  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102128861  [KO:K10134]
102129770  ADGRB1; adhesion G protein-coupled receptor B1 isoform X3 [KO:K04596]
102129859  MDM4; protein Mdm4 isoform X2 [KO:K10127]
102130245  THBS1; thrombospondin-1 [KO:K16857]
102130435  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
102133727  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
102133867  SFN; 14-3-3 protein sigma [KO:K06644]
102134073  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
102134214  CD82; CD82 antigen isoform X1 [KO:K06509]
102135100  COP1; E3 ubiquitin-protein ligase COP1 isoform X3 [KO:K10143] [EC:2.3.2.27]
102135329  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102135480  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102135720  EI24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
102135939  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
102135998  TP53; cellular tumor antigen P53 [KO:K04451]
102136063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102136323  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102136392  [KO:K08738]
102136678  SERPINB5; serpin B5 [KO:K10139]
102137473  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
102137525  ATM; serine-protein kinase ATM isoform X3 [KO:K04728] [EC:2.7.11.1]
102137575  AIFM2; ferroptosis suppressor protein 1 isoform X1 [KO:K22745]
102137662  TP53AIP1; LOW QUALITY PROTEIN: p53-regulated apoptosis-inducing protein 1 [KO:K13773]
102137714  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
102138212  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102138564  CCNE2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
102139233  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102139392  TP53I3; quinone oxidoreductase PIG3 isoform X2 [KO:K10133] [EC:1.-.-.-]
102139560  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
102140628  TSC2; tuberin isoform X1 [KO:K07207]
102140874  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
102141749  SIVA1; apoptosis regulatory protein Siva isoform X2 [KO:K22744]
102141866  [KO:K08738]
102142638  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102143770  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X4 [KO:K04506] [EC:2.3.2.27]
102144139  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102144301  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
102147003  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
102147140  [KO:K04506] [EC:2.3.2.27]
107127908  [KO:K08738]
107130218  [KO:K08738]
135964343  FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
mcf04110  Cell cycle
mcf04210  Apoptosis
mcf04218  Cellular senescence
KO pathway
ko04115   

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