KEGG   PATHWAY: mcf04210
Entry
mcf04210                    Pathway                                
Name
Apoptosis - Macaca fascicularis (crab-eating macaque)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
mcf04210  Apoptosis
mcf04210

Other DBs
GO: 0006915
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864918  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101865017  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
101865354  CASP8; caspase-8 isoform X3 [KO:K04398] [EC:3.4.22.61]
101865389  ITPR1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X2 [KO:K04958]
101865529  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X13 [KO:K06114]
101865772  [KO:K07374]
101866078  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101866285  FADD; FAS-associated death domain protein [KO:K02373]
101866349  SEPTIN4; septin-4 isoform X2 [KO:K16943]
101866379  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101867077  CASP6; caspase-6 isoform X3 [KO:K04396] [EC:3.4.22.59]
101867105  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
101867183  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101867458  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101867500  TUBA1B; tubulin alpha-1B chain [KO:K07374]
101867512  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X4 [KO:K03173] [EC:2.3.2.27]
101925224  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X2 [KO:K02539]
101925362  PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.-]
101925386  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101925452  TUBA3E; tubulin alpha-3E chain [KO:K07374]
101925538  NOL3; nucleolar protein 3 isoform X2 [KO:K28177]
101925579  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070]
101925657  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101925802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101926590  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101926805  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
102115080  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102115368  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102115744  ITPR2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
102115795  [KO:K04741] [EC:3.4.22.-]
102115935  CTSH; pro-cathepsin H isoform X1 [KO:K01366] [EC:3.4.22.16]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102116003  ITPR3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X1 [KO:K04960]
102116193  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102116556  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
102116663  CTSW; cathepsin W isoform X2 [KO:K08569] [EC:3.4.22.-]
102116769  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102117102  [KO:K08738]
102117377  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
102117895  DAB2IP; disabled homolog 2-interacting protein isoform X2 [KO:K19901]
102117938  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102118153  [KO:K05692]
102118362  IL3; interleukin-3 [KO:K04736]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102118566  CTSZ; cathepsin Z isoform X1 [KO:K08568] [EC:3.4.18.1]
102118744  HRAS; GTPase HRas [KO:K02833]
102119825  BBC3; bcl-2-binding component 3 isoform X3 [KO:K10132]
102120192  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 isoform X2 [KO:K10131]
102120205  CYCS; cytochrome c [KO:K08738]
102120307  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
102120416  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
102120796  CTSS; cathepsin S isoform X2 [KO:K01368] [EC:3.4.22.27]
102121218  [KO:K07374]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121921  BAD; bcl2-associated agonist of cell death [KO:K02158]
102122565  BCL2A1; bcl-2-related protein A1 [KO:K02162]
102122692  [KO:K03853] [EC:3.4.22.53]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102123291  LMNB1; lamin-B1 [KO:K07611]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102124998  CTSF; LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
102125087  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
102125241  PTPN13; tyrosine-protein phosphatase non-receptor type 13 isoform X3 [KO:K02374]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102125635  CTSD; cathepsin D isoform X2 [KO:K01379] [EC:3.4.23.5]
102125659  LMNA; lamin isoform X1 [KO:K12641]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102126399  [KO:K04725] [EC:2.3.2.27]
102126403  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
102126446  JUN; transcription factor Jun [KO:K04448]
102126830  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102127067  PRF1; perforin-1 [KO:K07818]
102127213  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
102127614  [KO:K08738]
102128083  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102128712  CASP2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
102128802  [KO:K07374]
102129364  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102130260  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
102131393  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102131405  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102131632  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
102132255  BAX; apoptosis regulator BAX isoform X7 [KO:K02159]
102132327  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132992  PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X1 [KO:K10798] [EC:2.4.2.-]
102133727  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
102134073  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
102134104  CTSV; cathepsin L2 [KO:K01375] [EC:3.4.22.43]
102134266  DFFA; DNA fragmentation factor subunit alpha isoform X1 [KO:K02310]
102135074  BCL2L11; bcl-2-like protein 11 isoform X4 [KO:K16341]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102135480  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102135998  TP53; cellular tumor antigen P53 [KO:K04451]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102137473  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
102137478  DIABLO; diablo IAP-binding mitochondrial protein isoform X1 [KO:K10522]
102137525  ATM; serine-protein kinase ATM isoform X5 [KO:K04728] [EC:2.7.11.1]
102137662  TP53AIP1; LOW QUALITY PROTEIN: p53-regulated apoptosis-inducing protein 1 [KO:K13773]
102137780  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102137913  NRAS; GTPase NRas [KO:K07828]
102138168  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X5 [KO:K16060]
102138212  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
102139042  PARP2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K28005]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102139560  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
102139631  TNF; tumor necrosis factor [KO:K03156]
102139853  ACTB; actin, cytoplasmic 1 [KO:K05692]
102140222  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
102140855  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102141627  ENDOG; endonuclease G, mitochondrial isoform X1 [KO:K01173]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102142357  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142800  DFFB; DNA fragmentation factor subunit beta isoform X1 [KO:K02311] [EC:3.-.-.-]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102143353  CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102143716  FOS; protein C-Fos [KO:K04379]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102144792  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102145538  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
102145584  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102145991  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102145994  [KO:K05692]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102146995  LMNB2; lamin-B2 isoform X2 [KO:K07611]
107127908  [KO:K08738]
107130218  [KO:K08738]
123567596  HRK; activator of apoptosis harakiri [KO:K02512]
135964343  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
135964355  [KO:K07210]
141409492  [KO:K04737]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Reference
PMID:36652128
  Authors
Liu K, Lan D, Li C, Liu S, Dai X, Song T, Wang X, Kong Q, He Z, Tan J, Zhang J
  Title
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury.
  Journal
Apoptosis 28:313-325 (2023)
DOI:10.1007/s10495-022-01802-4
Related
pathway
mcf04010  MAPK signaling pathway
mcf04020  Calcium signaling pathway
mcf04064  NF-kappa B signaling pathway
mcf04115  p53 signaling pathway
mcf04141  Protein processing in endoplasmic reticulum
mcf04151  PI3K-Akt signaling pathway
mcf04650  Natural killer cell mediated cytotoxicity
mcf04668  TNF signaling pathway
KO pathway
ko04210   

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