KEGG   PATHWAY: mcf04145
Entry
mcf04145                    Pathway                                
Name
Phagosome - Macaca fascicularis (crab-eating macaque)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
mcf04145  Phagosome
mcf04145

Other DBs
GO: 0045335
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101866513  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
101865243  STX12; syntaxin-12 isoform X1 [KO:K13813]
101867315  STX7; syntaxin-7 [KO:K08488]
102139853  ACTB; actin, cytoplasmic 1 [KO:K05692]
102120642  actin, cytoskeletal 4-like [KO:K05692]
101925802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101866695  CORO1A; coronin-1A [KO:K13882]
102127507  STX18; syntaxin-18 isoform X1 [KO:K08492]
102125148  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
102122138  MAFA-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
102138874  popy class I histocompatibility antigen, alpha chain E isoform X3 [KO:K06751]
102141835  class I histocompatibility antigen, Gogo-B*0101 alpha chain isoform X1 [KO:K06751]
102123548  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
102138883  MAFA-B; class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
102117143  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-1 alpha chain [KO:K06751]
102120132  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
102140002  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
102116527  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
102136468  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
102137481  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
102140649  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
102139994  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
102145413  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102132662  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
102144414  HLA class II histocompatibility antigen, DR beta 5 chain isoform X1 [KO:K06752]
102144039  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
102136862  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
102133044  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
123572852  H-2 class II histocompatibility antigen, A-D alpha chain-like [KO:K06752]
123572854  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
123572909  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102144117  RAB5A; ras-related protein Rab-5A [KO:K07887]
101865961  RAB5B; ras-related protein Rab-5B [KO:K07888]
102116190  RAB5C; ras-related protein Rab-5C [KO:K07889]
102133230  ras-related protein Rab-5C-like [KO:K07889]
101926553  EEA1; early endosome antigen 1 isoform X2 [KO:K12478]
102136293  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
102136007  TFRC; transferrin receptor protein 1 [KO:K06503]
102130302  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
102128783  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102115629  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
101925257  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102139650  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
102137126  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101866706  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101925234  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102121520  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101866302  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102137390  V-type proton ATPase subunit E 1 [KO:K02150]
102116490  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102139482  V-type proton ATPase subunit F-like [KO:K02151]
102117757  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101926631  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
102146711  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
123567930  V-type proton ATPase subunit G 1-like [KO:K02152]
107130518  V-type proton ATPase subunit G 1-like [KO:K02152]
102118989  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
123571659  V-type proton ATPase subunit e 1-like [KO:K02153]
102127734  ATP6V0E2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153]
102118312  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102127448  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
102118234  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101867133  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
102130688  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102143246  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
101926423  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102138620  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
102134327  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102121430  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X3 [KO:K03661]
102142621  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102143515  RAB7A; ras-related protein Rab-7a [KO:K07897]
102137760  RAB7B; ras-related protein Rab-7b isoform X4 [KO:K07898]
102145716  rab-interacting lysosomal protein isoform X1 [KO:K13883]
101867466  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
101865173  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X5 [KO:K10415]
101865816  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
102138451  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
102143512  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
102145991  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102121218  tubulin alpha-3 chain [KO:K07374]
102128802  TUBA1C; tubulin alpha-1C chain isoform X2 [KO:K07374]
101925452  TUBA3E; tubulin alpha-3E chain [KO:K07374]
101867500  TUBA1B; tubulin alpha-1B chain [KO:K07374]
101867105  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
101865772  TUBA1A; tubulin alpha-1A chain isoform X2 [KO:K07374]
101926805  TUBA4A; tubulin alpha-4A chain isoform X2 [KO:K07374]
102125060  tubulin beta chain-like [KO:K07375]
102139269  tubulin beta-8 chain [KO:K07375]
102118944  TUBB1; tubulin beta-1 chain [KO:K07375]
102137566  tubulin beta-8 chain [KO:K07375]
101925816  TUBB; tubulin beta chain isoform X1 [KO:K07375]
101866438  TUBB4B; tubulin beta-4B chain [KO:K07375]
102116211  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
102114855  TUBB2A; tubulin beta-2A chain [KO:K07375]
101866604  tubulin beta-2B chain [KO:K07375]
101925940  TUBB3; tubulin beta-3 chain [KO:K07375]
102123543  LOW QUALITY PROTEIN: tubulin beta-8 chain-like [KO:K07375]
123569396  tubulin beta-4B chain isoform X1 [KO:K07375]
102129286  TUBB4A; tubulin beta-4A chain [KO:K07375]
102131065  uncharacterized protein LOC102131065 [KO:K07375]
101867227  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
102119735  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
102116640  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
101866280  M6PR; cation-dependent mannose-6-phosphate receptor isoform X3 [KO:K10089]
102123521  NOS1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
102130410  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
102116556  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
102118013  LOW QUALITY PROTEIN: putative inactive cathepsin L-like protein CTSL3P [KO:K01365] [EC:3.4.22.15]
102123755  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
102120796  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
102119298  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
102116756  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
102114907  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
102140351  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
102142346  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102143391  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102121336  CALR; calreticulin [KO:K08057]
101925077  CANX; calnexin isoform X1 [KO:K08054]
102145896  FCAR; immunoglobulin alpha Fc receptor isoform X1 [KO:K06513]
102147198  FCGR1A; LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
102143568  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
102139530  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
102140945  FCGR3A; LOW QUALITY PROTEIN: low affinity immunoglobulin gamma Fc region receptor III [KO:K06463]
102124047  uncharacterized protein LOC102124047 [KO:K06856]
102122532  immunoglobulin heavy variable 4-4 [KO:K06856]
107130290  uncharacterized protein LOC107130290 [KO:K06856]
123574606  uncharacterized protein LOC123574606 [KO:K06856]
101866354  complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
102135038  LOW QUALITY PROTEIN: complement C1r subcomponent-like [KO:K01330] [EC:3.4.21.41]
101866035  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101925124  ITGB2; integrin beta-2 [KO:K06464]
102131458  C3; complement C3 [KO:K03990]
101865948  COLEC11; collectin-11 isoform X1 [KO:K10066]
102143611  COLEC12; collectin-12 [KO:K10062]
102119426  mannose-binding protein A-like [KO:K03991]
102120567  MBL2; mannose-binding protein C isoform X2 [KO:K03991]
123575476  LOW QUALITY PROTEIN: mannose-binding protein A-like [KO:K03991]
102119686  pulmonary surfactant-associated protein A-like [KO:K10067]
102121713  pulmonary surfactant-associated protein A-like isoform X3 [KO:K10067]
102119798  SFTPA1; pulmonary surfactant-associated protein A1 isoform X1 [KO:K10067]
102119038  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
102116249  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
102133302  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
102114969  ITGA5; integrin alpha-5 [KO:K06484]
102144610  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102117791  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102123619  ITGB5; integrin beta-5 [KO:K06588]
102130245  THBS1; thrombospondin-1 [KO:K16857]
102120028  THBS3; thrombospondin-3 isoform X3 [KO:K04659]
102125342  THBS2; thrombospondin-2 [KO:K04659]
102129227  THBS4; thrombospondin-4 [KO:K04659]
101867220  cartilage oligomeric matrix protein [KO:K04659]
102146068  TLR2; toll-like receptor 2 [KO:K10159]
102139888  TLR6; toll-like receptor 6 [KO:K10169]
102136906  TLR4; toll-like receptor 4 isoform X2 [KO:K10160]
102129342  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
101925909  MRC1; macrophage mannose receptor 1 [KO:K06560]
101925075  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
102120986  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
102120328  CD209 antigen-like protein 2 isoform X1 [KO:K06563]
102121984  CD209 antigen isoform X3 [KO:K06563]
102115991  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
102134754  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
102137861  MARCO; macrophage receptor MARCO isoform X1 [KO:K13884]
102117699  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
102141434  SCARB1; scavenger receptor class B member 1 isoform X4 [KO:K13885]
101926577  CD36; platelet glycoprotein 4 [KO:K06259]
102143777  cytochrome b-245 light chain isoform X2 [KO:K08009]
102122418  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102134837  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102124562  NCF1; neutrophil cytosol factor 1 [KO:K08011]
102123175  NCF2; neutrophil cytosol factor 2 [KO:K08010]
102143747  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
mcf04142  Lysosome
mcf04144  Endocytosis
mcf04610  Complement and coagulation cascades
mcf04612  Antigen processing and presentation
mcf04620  Toll-like receptor signaling pathway
mcf04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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