KEGG   PATHWAY: mcf04620
Entry
mcf04620                    Pathway                                
Name
Toll-like receptor signaling pathway - Macaca fascicularis (crab-eating macaque)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
mcf04620  Toll-like receptor signaling pathway
mcf04620

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101865354  CASP8; caspase-8 isoform X3 [KO:K04398] [EC:3.4.22.61]
101865975  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101866285  FADD; FAS-associated death domain protein [KO:K02373]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101866832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101867458  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101925060  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X4 [KO:K04433] [EC:2.7.12.2]
101925134  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
101926190  IFNAR1; interferon alpha/beta receptor 1 isoform X3 [KO:K05130]
101926590  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
102115289  [KO:K05414]
102115316  IL12A; interleukin-12 subunit alpha [KO:K05406]
102115368  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102115670  IFNB1; interferon beta [KO:K05415]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102116823  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102117046  TOLLIP; toll-interacting protein isoform X6 [KO:K05402]
102117457  IRF5; interferon regulatory factor 5 isoform X1 [KO:K09446]
102117861  [KO:K12964]
102118010  TLR5; toll-like receptor 5 [KO:K10168]
102118223  [KO:K05408]
102118398  LY96; lymphocyte antigen 96 isoform X6 [KO:K05400]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102118696  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
102119743  [KO:K05408]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102120416  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
102121169  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102122493  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102122857  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102123983  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102124806  LBP; lipopolysaccharide-binding protein isoform X1 [KO:K05399]
102124858  IL12B; interleukin-12 subunit beta [KO:K05425]
102125035  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102126428  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102126446  JUN; transcription factor Jun [KO:K04448]
102126975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
102127272  CXCL8; interleukin-8 [KO:K10030]
102128596  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102129342  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
102130894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
102132599  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132745  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102133020  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
102133945  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
102134351  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134708  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
102134829  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
102136134  CCL3; C-C motif chemokine 3 [KO:K05408]
102136805  [KO:K12964]
102136906  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102137879  SPP1; osteopontin [KO:K06250]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
102138517  TLR3; toll-like receptor 3 [KO:K05401]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102139002  TLR1; toll-like receptor 1 [KO:K05398]
102139628  TLR7; toll-like receptor 7 [KO:K05404]
102139631  TNF; tumor necrosis factor [KO:K03156]
102139888  TLR6; toll-like receptor 6 [KO:K10169]
102139990  TLR8; toll-like receptor 8 precursor [KO:K10170]
102140078  CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412]
102140083  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
102140231  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102140303  [KO:K05414]
102140498  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102140855  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102140954  [KO:K05414]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102141352  [KO:K05414]
102141355  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102141744  [KO:K05414]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102142148  [KO:K05414]
102142245  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
102142271  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102143043  [KO:K05414]
102143094  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102143716  FOS; protein C-Fos [KO:K04379]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102144479  [KO:K05414]
102144774  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102144833  [KO:K05414]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102145208  [KO:K05414]
102145962  [KO:K05414]
102146068  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
102146344  [KO:K05414]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102146717  [KO:K05414]
102147079  [KO:K05414]
102147235  CD86; T-lymphocyte activation antigen CD86 isoform X6 [KO:K05413]
107127795  CCL5; C-C motif chemokine 5 [KO:K12499]
123569038  [KO:K05414]
135964355  [KO:K07210]
135967426  [KO:K05414]
135967619  [KO:K05408]
135967628  [KO:K12964]
135967642  [KO:K12964]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
mcf04010  MAPK signaling pathway
mcf04060  Cytokine-cytokine receptor interaction
mcf04064  NF-kappa B signaling pathway
mcf04120  Ubiquitin mediated proteolysis
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04610  Complement and coagulation cascades
mcf04630  JAK-STAT signaling pathway
KO pathway
ko04620   

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