KEGG   PATHWAY: mcoc04141
Entry
mcoc04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Mastomys coucha (southern multimammate mouse)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
mcoc04141  Protein processing in endoplasmic reticulum
mcoc04141

Other DBs
GO: 0030433 0034976
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116099225  Sec61a1; protein transport protein Sec61 subunit alpha [KO:K10956]
116082463  Sec61a2; protein transport protein Sec61 subunit alpha [KO:K10956]
116095985  Sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
116082292  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116094168  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116075960  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116068195  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116070121  Sec61g; LOW QUALITY PROTEIN: protein transport protein Sec61 subunit gamma [KO:K07342]
116090041  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116071338  protein transport protein Sec61 subunit gamma [KO:K07342]
116072510  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116095041  Sec62; translocation protein SEC62 isoform X1 [KO:K12275]
116075444  Sec63; translocation protein SEC63 homolog isoform X1 [KO:K09540]
116099218  Rpn1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
116091286  Rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
116084297  Dad1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
116096900  Ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
116073583  Stt3b; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
116071916  Stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1 [KO:K07151] [EC:2.4.99.18]
116087979  Magt1; magnesium transporter protein 1 [KO:K19478]
116069174  Tusc3; tumor suppressor candidate 3 isoform X1 [KO:K19478]
116093787  Ostc; oligosaccharyltransferase complex subunit OSTC [KO:K26501]
116103549  Tmem258; transmembrane protein 258 [KO:K26502]
116099128  Mogs; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
116076170  Ckap4; cytoskeleton-associated protein 4 [KO:K13999]
116091805  Rrbp1; ribosome-binding protein 1 [KO:K14000]
116086992  Sil1; nucleotide exchange factor SIL1 isoform X1 [KO:K14001]
116072969  Hyou1; hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
116090044  Hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
116085749  Dnajb11; dnaJ homolog subfamily B member 11 [KO:K09517]
116089743  Dnajc1; dnaJ homolog subfamily C member 1 [KO:K09521]
116084308  Dnajc3; dnaJ homolog subfamily C member 3 [KO:K09523]
116090376  Dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
116075702  Hsp90b1; endoplasmin [KO:K09487]
116103526  Ganab; neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
116072351  Prkcsh; glucosidase 2 subunit beta isoform X1 [KO:K08288]
116077844  Canx; calnexin [KO:K08054]
116090801  Pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
116096395  calreticulin-like isoform X1 [KO:K08057]
116069729  Calr; calreticulin [KO:K08057]
116096817  Man1c1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [KO:K01230] [EC:3.2.1.113]
116075084  Man1a1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
116093501  Man1a2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
116089811  Man1b1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
116081967  Lman2; vesicular integral-membrane protein VIP36 [KO:K10082]
116087278  Lman1; protein ERGIC-53 [KO:K10080]
116071966  Lman1l; protein ERGIC-53-like isoform X1 [KO:K10081]
116080051  Preb; prolactin regulatory element-binding protein isoform X1 [KO:K14003]
116074882  Sar1a; GTP-binding protein SAR1a [KO:K07953] [EC:3.6.5.-]
116077826  Sar1b; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
116099412  Sec13; protein SEC13 homolog [KO:K14004]
116103896  Sec31b; protein transport protein Sec31B isoform X1 [KO:K14005]
116067938  Sec31a; protein transport protein Sec31A isoform X1 [KO:K14005]
116079611  Sec23a; protein transport protein Sec23A [KO:K14006]
116091070  Sec23b; protein transport protein Sec23B [KO:K14006]
116084312  Sec24c; protein transport protein Sec24C isoform X1 [KO:K14007]
116093734  Sec24d; protein transport protein Sec24D isoform X1 [KO:K14007]
116093784  Sec24b; protein transport protein Sec24B isoform X1 [KO:K14007]
116076774  Sec24a; protein transport protein Sec24A [KO:K14007]
116084234  Uggt2; UDP-glucose:glycoprotein glucosyltransferase 2 [KO:K11718] [EC:2.4.1.-]
116088291  Uggt1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
116099366  Edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
116091245  Edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
116100905  Edem3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
116077565  P4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
116098842  Pdia4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
116080802  Pdia6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
116068343  Erp29; endoplasmic reticulum resident protein 29 [KO:K09586]
116082766  Txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
116084479  Ero1a; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
116082708  Ero1b; ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
116076136  Os9; protein OS-9 isoform X1 [KO:K10088]
116070558  Erlec1; endoplasmic reticulum lectin 1 [KO:K14008]
116081487  Ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
116093136  Ssr2; translocon-associated protein subunit beta [KO:K13250]
116092952  Ssr3; translocon-associated protein subunit gamma [KO:K13251]
116086016  Ssr4; translocon-associated protein subunit delta isoform X1 [KO:K04571]
116085998  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
116093742  Tram1l1; translocating chain-associated membrane protein 1-like 1 [KO:K14010]
116088185  Tram1; translocating chain-associated membrane protein 1 [KO:K14010]
116081723  Derl1; derlin-1 [KO:K11519]
116074241  Derl3; derlin-3 isoform X1 [KO:K13989]
116077015  Derl2; derlin-2 isoform X1 [KO:K13989]
116103522  Ubxn1; UBX domain-containing protein 1 [KO:K24348]
116098606  Ubxn4; UBX domain-containing protein 4 isoform X1 [KO:K24348]
116079979  Ubxn2a; LOW QUALITY PROTEIN: UBX domain-containing protein 2A [KO:K24349]
116075489  Ubxn6; UBX domain-containing protein 6 [KO:K14011]
116104773  Ubxn8; UBX domain-containing protein 8 [KO:K24351]
116091139  Nsfl1c; NSFL1 cofactor p47 isoform X1 [KO:K14012]
116102286  Svip; small VCP/p97-interacting protein isoform X1 [KO:K14014]
116095875  Vcp; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
116078806  Nploc4; nuclear protein localization protein 4 homolog [KO:K14015]
116085701  Ufd1; ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1 [KO:K14016]
116103294  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
116074790  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
116075039  heat shock 70 kDa protein 1A [KO:K03283]
116073211  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
116095824  Dnaja1; dnaJ homolog subfamily A member 1 [KO:K09502]
116067853  Dnaja2; dnaJ homolog subfamily A member 2 [KO:K09503]
116067849  Dnajb1; dnaJ homolog subfamily B member 1 [KO:K09507]
116088602  Dnajb2; dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
116074758  Dnajb12; dnaJ homolog subfamily B member 12 isoform X1 [KO:K09518]
116094982  Dnajc5b; dnaJ homolog subfamily C member 5B [KO:K09525]
116080226  Dnajc5g; dnaJ homolog subfamily C member 5G [KO:K09525]
116091573  Dnajc5; dnaJ homolog subfamily C member 5 [KO:K09525]
116074367  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
116081114  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
116095129  Hspa4l; heat shock 70 kDa protein 4L [KO:K09485]
116068806  Hsph1; heat shock protein 105 kDa isoform X1 [KO:K09485]
116095828  Bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
116088274  Bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
116101556  Hspbp1; hsp70-binding protein 1 isoform X1 [KO:K09562]
116074765  Cryaa; alpha-crystallin A chain isoform X1 [KO:K09541]
116073320  Cryab; alpha-crystallin B chain [KO:K09542]
116098739  Yod1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
116095728  Plaa; phospholipase A-2-activating protein [KO:K14018]
116096033  Rad23b; UV excision repair protein RAD23 homolog B isoform X1 [KO:K10839]
116069726  Rad23a; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
116102711  Ubqln3; ubiquilin-3 isoform X1 [KO:K04523]
116093134  Ubqln4; ubiquilin-4 [KO:K04523]
116090013  Ubqln2; ubiquilin-2 [KO:K04523]
116081611  Ubqln1; ubiquilin-1 isoform X1 [KO:K04523]
116085427  Ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
116079734  Atxn3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
116097033  Ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
116099053  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
116080060  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116090338  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
116076129  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116102205  Ppp1r15a; protein phosphatase 1 regulatory subunit 15A [KO:K14019]
116076417  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
116097315  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
116103242  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
116075007  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
116070479  Wfs1; wolframin [KO:K14020]
116070271  Mbtps1; membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
116090057  Mbtps2; membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
116069833  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
116076830  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116089826  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
116097922  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
116068848  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116102201  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
116075029  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
116103425  Capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
116068107  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
116073421  caspase-12 [KO:K04741] [EC:3.4.22.-]
116083791  Marchf6; E3 ubiquitin-protein ligase MARCH6 isoform X1 [KO:K10661] [EC:2.3.2.27]
116087989  Ube2j1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
116097166  Ube2j2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
116077899  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
116074817  Ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
116103427  Syvn1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
116069756  Rnf185; E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
116075333  Rnf5; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
116102350  Selenos; selenoprotein S isoform X1 [KO:K14025]
116079653  Sel1l; protein sel-1 homolog 1 isoform X1 [KO:K14026]
116091025  Sel1l2; protein sel-1 homolog 2 isoform X1 [KO:K14026]
116069899  Herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
116069886  Amfr; E3 ubiquitin-protein ligase AMFR isoform X1 [KO:K10636] [EC:2.3.2.36]
116076726  Stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
116101411  ubiquitin-conjugating enzyme E2-24 kDa-like [KO:K06689] [EC:2.3.2.23]
116074575  Ube2d1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
116093820  Ube2d3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
116094066  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
116068076  ubiquitin-conjugating enzyme E2 D2B [KO:K06689] [EC:2.3.2.23]
116087004  Ube2d2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
116069280  Ube2d4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
116076805  Prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
116076358  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
116098531  Cul1; cullin-1 [KO:K03347]
116078246  Skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
116095672  Fbxo2; F-box only protein 2 [KO:K10099]
116097010  Fbxo6; F-box only protein 6 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
mcoc00510  N-Glycan biosynthesis
mcoc03050  Proteasome
mcoc03060  Protein export
mcoc04210  Apoptosis
mcoc04930  Type II diabetes mellitus
mcoc05010  Alzheimer disease
mcoc05012  Parkinson disease
mcoc05020  Prion disease
KO pathway
ko04141   
LinkDB

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