KEGG   PATHWAY: mcoc05012
Entry
mcoc05012                   Pathway                                
Name
Parkinson disease - Mastomys coucha (southern multimammate mouse)
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mcoc05012  Parkinson disease
mcoc05012

Disease
H00057  Parkinson disease
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116068035  [KO:K05863]
116068251  [KO:K02266]
116068387  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
116068749  [KO:K05863]
116069012  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116069234  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116069264  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116069335  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
116069436  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
116069469  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
116069534  [KO:K00419]
116069684  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116069833  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
116069997  [KO:K02183]
116070128  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 isoform X1 [KO:K03038]
116070294  [KO:K02263]
116070367  Tubb3; tubulin beta-3 chain [KO:K07375]
116071098  Uchl1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
116071167  [KO:K02271]
116071446  Slc18a1; chromaffin granule amine transporter [KO:K08155]
116071698  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
116071976  [KO:K02264]
116072321  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
116073065  [KO:K00414]
116073071  Uba7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
116073091  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
116073180  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
116073347  [KO:K02270]
116073401  Uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
116073403  Drd2; D(2) dopamine receptor isoform X1 [KO:K04145]
116073523  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116073836  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
116073905  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
116074216  [KO:K02927]
116074256  Slc39a7; zinc transporter SLC39A7 [KO:K14713]
116074272  Tubb4a; tubulin beta-4A chain [KO:K07375]
116074595  [KO:K00413]
116074609  Tubb; tubulin beta chain [KO:K07375]
116074817  Ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
116074836  Klc4; kinesin light chain 4 isoform X1 [KO:K10407]
116074922  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
116075043  Adora2a; adenosine receptor A2a [KO:K04266]
116075120  Daxx; death domain-associated protein 6 [KO:K02308]
116075130  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
116075282  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
116075300  Txn2; thioredoxin, mitochondrial [KO:K03671]
116075389  [KO:K07375]
116075536  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116075723  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
116075740  [KO:K00420]
116075741  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
116076048  Kif5a; kinesin heavy chain [KO:K10396]
116076129  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116076143  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
116076179  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
116076188  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
116076237  Slc39a3; zinc transporter ZIP3 [KO:K14709]
116076307  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
116076417  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
116076451  Slc39a5; zinc transporter ZIP5 isoform X1 [KO:K14711]
116076583  Atp5f1d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
116076712  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
116076748  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076805  Prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
116076830  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116076902  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
116077049  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
116077055  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
116077116  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
116077266  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
116077281  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
116077290  [KO:K00418]
116077347  Slc39a11; zinc transporter ZIP11 isoform X1 [KO:K14717]
116077484  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
116077859  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
116077868  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
116077881  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
116077899  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
116078213  Lrrk2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
116078286  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116078462  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
116078655  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116079278  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
116079645  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
116079709  Slc39a9; zinc transporter ZIP9 [KO:K14715]
116079733  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
116079784  Slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
116079808  Calm1; calmodulin-1 [KO:K02183]
116079993  Calm2; calmodulin-2 [KO:K02183]
116080060  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116080102  Psma6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
116080143  [KO:K04551]
116080165  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
116080263  [KO:K02273]
116080462  [KO:K02270]
116080645  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
116080751  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
116080991  [KO:K03949]
116081410  Slc39a4; zinc transporter ZIP4 [KO:K14710]
116081777  [KO:K02183]
116081974  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
116082198  [KO:K00411] [EC:7.1.1.8]
116082347  [KO:K00417]
116082411  [KO:K02183]
116082435  Drd1; D(1A) dopamine receptor [KO:K04144]
116082439  [KO:K02268]
116082443  [KO:K04551]
116082579  [KO:K02136]
116082583  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
116082796  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
116083177  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
116083193  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
116083218  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
116083615  [KO:K02272]
116083700  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
116084153  Trap1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
116084380  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116084433  Slc39a14; zinc transporter ZIP14 isoform X1 [KO:K14720]
116084504  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
116084513  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
116084704  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
116084777  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116084823  Slc39a2; zinc transporter ZIP2 isoform X1 [KO:K14709]
116084899  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116085649  Ube2l3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
116085697  Septin5; septin-5 isoform X1 [KO:K04557]
116085728  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
116085856  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116085890  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
116086109  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
116086146  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
116086810  Kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
116086864  Psma8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
116086926  Slc39a6; zinc transporter ZIP6 [KO:K14712]
116087026  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
116087159  Sncaip; synphilin-1 isoform X1 [KO:K04558]
116087223  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116087292  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
116087298  Tubb6; tubulin beta-6 chain [KO:K07375]
116087380  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
116087411  [KO:K04552] [EC:2.3.2.23]
116087665  [KO:K04551]
116087988  [KO:K02271]
116087989  Ube2j1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
116088312  [KO:K02265]
116088418  Slc39a10; zinc transporter ZIP10 isoform X1 [KO:K14716]
116088464  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
116088686  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
116088778  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
116088857  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
116088942  [KO:K07374]
116089452  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
116089797  Tubb4b; tubulin beta-4B chain [KO:K07375]
116090044  Hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
116090075  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
116090105  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
116090151  Kif5c; kinesin heavy chain [KO:K10396]
116090221  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
116090323  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
116090338  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
116090342  [KO:K08738]
116090402  Ube2l6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
116090451  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
116090454  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
116090456  Slc39a13; zinc transporter ZIP13 isoform X1 [KO:K14719]
116090647  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
116091179  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
116091233  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
116091317  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116091495  [KO:K04632]
116091496  [KO:K04632]
116091502  Tubb1; tubulin beta-1 chain [KO:K07375]
116091503  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
116091522  Psma7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
116091526  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
116091802  Maob; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
116091857  Slc39a12; zinc transporter ZIP12 [KO:K14718]
116092456  [KO:K02263]
116093213  Slc39a1; zinc transporter ZIP1 [KO:K14709]
116093378  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
116093388  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
116093578  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
116093617  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116093624  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
116093748  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116093826  Slc39a8; zinc transporter ZIP8 [KO:K14714]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116094815  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
116095059  Mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
116095068  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
116095820  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
116096063  Txn; thioredoxin [KO:K03671]
116096453  [KO:K00416]
116096591  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
116096647  Psmb2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
116096899  Pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
116096943  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
116096967  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
116097001  Mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
116097068  Park7; protein/nucleic acid deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
116097166  Ube2j2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
116097497  [KO:K04630]
116097517  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
116097922  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
116098456  [KO:K07374]
116098557  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
116098581  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
116098636  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
116098640  Gpr37; prosaposin receptor GPR37 [KO:K04243]
116098773  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
116098897  [KO:K08738]
116098989  [KO:K02136]
116098998  Snca; alpha-synuclein [KO:K04528]
116099029  [KO:K05862]
116099053  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
116099123  Htra2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
116099362  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116099526  Tuba8; tubulin alpha-8 chain [KO:K07374]
116099610  [KO:K07374]
116099623  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
116099794  [KO:K07374]
116099798  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116100325  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
116100436  [KO:K02270]
116100918  [KO:K02266]
116100960  [KO:K02273]
116101375  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
116101528  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
116101559  [KO:K02267]
116101711  Calm3; calmodulin-3 [KO:K02183]
116101752  Klc3; kinesin light chain 3 [KO:K10407]
116101900  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
116101988  [KO:K02267]
116102201  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
116102591  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
116102663  [KO:K02183]
116102829  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
116102887  [KO:K00415]
116102910  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
116103242  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
116103251  Th; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
116103302  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
116103309  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
116103322  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
116103359  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
116103373  Klc2; kinesin light chain 2 [KO:K10407]
116103484  [KO:K02273]
116103899  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
116104058  Slc18a2; synaptic vesicular amine transporter isoform X1 [KO:K08155]
34682989  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
34682993  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
34682999  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
34683002  COX2; cytochrome c oxidase subunit II [KO:K02261]
34683004  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
34683005  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
34683006  COX3; cytochrome c oxidase subunit III [KO:K02262]
34683008  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
34683010  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
34683011  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
34683015  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
34683016  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
34683018  CYTB; cytochrome b [KO:K00412]
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
Reference
PMID:16495942
  Authors
Abou-Sleiman PM, Muqit MM, Wood NW
  Title
Expanding insights of mitochondrial dysfunction in Parkinson's disease.
  Journal
Nat Rev Neurosci 7:207-19 (2006)
DOI:10.1038/nrn1868
Reference
PMID:12938733
  Authors
Lim KL, Lim TM
  Title
Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
  Journal
IUBMB Life 55:315-22 (2003)
DOI:10.1080/1521654031000153030
Reference
PMID:26501339
  Authors
Bobela W, Aebischer P, Schneider BL
  Title
Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
  Journal
Biomolecules 5:2675-700 (2015)
DOI:10.3390/biom5042675
Reference
PMID:15767499
  Authors
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  Title
Molecular pathogenesis of Parkinson disease.
  Journal
Arch Neurol 62:353-7 (2005)
DOI:10.1001/archneur.62.3.353
Reference
PMID:16972273
  Authors
Olanow CW, McNaught KS
  Title
Ubiquitin-proteasome system and Parkinson's disease.
  Journal
Mov Disord 21:1806-23 (2006)
DOI:10.1002/mds.21013
Reference
PMID:18047737
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Lim KL, Tan JM
  Title
Role of the ubiquitin proteasome system in Parkinson's disease.
  Journal
BMC Biochem 8 Suppl 1:S13 (2007)
DOI:10.1186/1471-2091-8-S1-S13
Reference
PMID:29090092
  Authors
Maiti P, Manna J, Dunbar GL
  Title
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.
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Transl Neurodegener 6:28 (2017)
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Reference
PMID:12814656
  Authors
Dev KK, van der Putten H, Sommer B, Rovelli G
  Title
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Neuropharmacology 45:1-13 (2003)
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Reference
PMID:20495568
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  Title
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  Journal
Nat Med 16:653-61 (2010)
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Reference
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  Authors
Cali T, Ottolini D, Brini M
  Title
Calcium signaling in Parkinson's disease.
  Journal
Cell Tissue Res 357:439-54 (2014)
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Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:28468938
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  Title
The role of Ca(2+) signaling in Parkinson's disease.
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Dis Model Mech 10:519-535 (2017)
DOI:10.1242/dmm.028738
Reference
PMID:28838811
  Authors
Ludtmann MHR, Abramov AY
  Title
Mitochondrial calcium imbalance in Parkinson's disease.
  Journal
Neurosci Lett 663:86-90 (2018)
DOI:10.1016/j.neulet.2017.08.044
Reference
PMID:19663908
  Authors
Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Minguez A
  Title
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
  Journal
FEBS J 276:5041-52 (2009)
DOI:10.1111/j.1742-4658.2009.07201.x
Reference
PMID:23352769
  Authors
Mercado G, Valdes P, Hetz C
  Title
An ERcentric view of Parkinson's disease.
  Journal
Trends Mol Med 19:165-75 (2013)
DOI:10.1016/j.molmed.2012.12.005
Reference
PMID:27103567
  Authors
Mercado G, Castillo V, Soto P, Sidhu A
  Title
ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
  Journal
Brain Res 1648:626-632 (2016)
DOI:10.1016/j.brainres.2016.04.042
Reference
PMID:26297973
  Authors
Tsujii S, Ishisaka M, Hara H
  Title
Modulation of endoplasmic reticulum stress in Parkinson's disease.
  Journal
Eur J Pharmacol 765:154-6 (2015)
DOI:10.1016/j.ejphar.2015.08.033
Reference
PMID:31100053
  Authors
Shah A, Chao J, Legido-Quigley C, Chang RC
  Title
Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
  Journal
Nutr Neurosci 1-16 (2019)
DOI:10.1080/1028415X.2019.1613764
Reference
PMID:24548101
  Authors
Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA
  Title
Protective and toxic roles of dopamine in Parkinson's disease.
  Journal
J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686
Reference
PMID:31587020
  Authors
Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
  Journal
Acta Neurobiol Exp (Wars) 79:276-289 (2019)
Reference
PMID:15189334
  Authors
Perez RG, Hastings TG
  Title
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
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J Neurochem 89:1318-24 (2004)
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Reference
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  Authors
Segura-Aguilar J
  Title
A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
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Neural Regen Res 10:1225-7 (2015)
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Reference
PMID:27546335
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  Title
Mitochondrial dysfunction in Parkinson's disease.
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J Neurochem 139 Suppl 1:216-231 (2016)
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Reference
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  Title
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness.
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Biochem Biophys Res Commun 483:1020-1030 (2017)
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PMID:27829983
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Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD
  Title
Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
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Oxid Med Cell Longev 2016:3472032 (2016)
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Reference
PMID:21674642
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Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.
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Reference
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Gaki GS, Papavassiliou AG
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Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease.
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Neuromolecular Med 16:217-30 (2014)
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Reference
PMID:25761946
  Authors
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The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
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Neuroscientist 22:266-77 (2016)
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Reference
PMID:22926193
  Authors
de Vries RL, Przedborski S
  Title
Mitophagy and Parkinson's disease: be eaten to stay healthy.
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Mol Cell Neurosci 55:37-43 (2013)
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Reference
PMID:20736035
  Authors
Deas E, Wood NW, Plun-Favreau H
  Title
Mitophagy and Parkinson's disease: the PINK1-parkin link.
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Biochim Biophys Acta 1813:623-33 (2011)
DOI:10.1016/j.bbamcr.2010.08.007
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
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Neuron 85:257-73 (2015)
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Reference
PMID:27911343
  Authors
Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W
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PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
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J Parkinsons Dis 7:13-29 (2017)
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Reference
PMID:28823929
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Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
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Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
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Neurobiol Dis 108:65-72 (2017)
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Reference
PMID:29147906
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Oh SE, Mouradian MM
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Regulation of Signal Transduction by DJ-1.
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Adv Exp Med Biol 1037:97-131 (2017)
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Reference
PMID:31054074
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Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
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Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
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J Bioenerg Biomembr 51:175-188 (2019)
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Reference
PMID:30370500
  Authors
Melo TQ, Copray SJCVM, Ferrari MFR
  Title
Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
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Neurochem Res 43:2212-2223 (2018)
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Reference
PMID:30937538
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Zhai S, Shen W, Graves SM, Surmeier DJ
  Title
Dopaminergic modulation of striatal function and Parkinson's disease.
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J Neural Transm (Vienna) 126:411-422 (2019)
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Reference
PMID:29720658
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Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ
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Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
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Nature 557:177-182 (2018)
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Related
pathway
mcoc00190  Oxidative phosphorylation
mcoc00350  Tyrosine metabolism
mcoc03050  Proteasome
mcoc04020  Calcium signaling pathway
mcoc04120  Ubiquitin mediated proteolysis
mcoc04137  Mitophagy - animal
mcoc04141  Protein processing in endoplasmic reticulum
mcoc04210  Apoptosis
mcoc04728  Dopaminergic synapse
KO pathway
ko05012   

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