KEGG   PATHWAY: mcoc05020
Entry
mcoc05020                   Pathway                                
Name
Prion disease - Mastomys coucha (southern multimammate mouse)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mcoc05020  Prion disease
mcoc05020

Disease
H00061  Prion disease
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116068035  [KO:K05863]
116068251  [KO:K02266]
116068387  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116068749  [KO:K05863]
116069012  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116069234  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116069354  [KO:K21421] [EC:1.-.-.-]
116069436  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116069534  [KO:K00419]
116069682  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116069684  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116069938  Csnk2a2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
116070128  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 isoform X1 [KO:K03038]
116070294  [KO:K02263]
116070330  [KO:K08009]
116070367  Tubb3; tubulin beta-3 chain [KO:K07375]
116071167  [KO:K02271]
116071362  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
116071976  [KO:K02264]
116073065  [KO:K00414]
116073091  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
116073180  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
116073211  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
116073347  [KO:K02270]
116073421  [KO:K04741] [EC:3.4.22.-]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116073836  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
116073852  Ncam1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116074272  Tubb4a; tubulin beta-4A chain [KO:K07375]
116074547  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
116074574  Fyn; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
116074595  [KO:K00413]
116074609  Tubb; tubulin beta chain [KO:K07375]
116074790  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
116074836  Klc4; kinesin light chain 4 isoform X1 [KO:K10407]
116074922  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
116074950  Csnk2b; casein kinase II subunit beta isoform X1 [KO:K03115]
116075007  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
116075039  [KO:K03283]
116075101  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116075130  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
116075282  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
116075335  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
116075389  [KO:K07375]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116075516  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116075536  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116075723  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
116075740  [KO:K00420]
116075741  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
116076048  Kif5a; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
116076095  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
116076129  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116076143  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
116076179  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
116076188  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
116076210  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
116076307  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
116076417  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
116076583  Atp5f1d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
116076712  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
116076748  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116077049  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
116077055  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
116077266  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
116077281  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
116077290  [KO:K00418]
116077484  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
116077650  Ccl5; C-C motif chemokine 5 [KO:K12499]
116077765  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077791  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077859  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
116077868  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
116077881  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
116078169  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
116078462  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
116078655  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116079278  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
116079645  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
116079733  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
116080060  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116080102  Psma6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
116080165  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
116080263  [KO:K02273]
116080462  [KO:K02270]
116080645  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
116080751  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
116080991  [KO:K03949]
116081429  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
116081974  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
116082198  [KO:K00411] [EC:7.1.1.8]
116082347  [KO:K00417]
116082439  [KO:K02268]
116082579  [KO:K02136]
116082583  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
116082796  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
116083193  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
116083218  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
116083233  C6; complement component C6 [KO:K03995]
116083417  C7; complement component C7 [KO:K03996]
116083615  [KO:K02272]
116083700  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116083932  C9; complement component C9 isoform X1 [KO:K04000]
116084124  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084337  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
116084380  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116084504  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
116084513  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
116084704  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
116084832  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084899  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
116084963  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116085415  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116085728  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
116085890  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
116085894  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116086077  Ncam2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
116086109  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
116086146  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
116086810  Kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
116086864  Psma8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
116086984  Egr1; early growth response protein 1 [KO:K09203]
116087026  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
116087298  Tubb6; tubulin beta-6 chain [KO:K07375]
116087380  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
116087988  [KO:K02271]
116088312  [KO:K02265]
116088464  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
116088513  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
116088686  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
116088778  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
116088857  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
116088942  [KO:K07374]
116089452  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
116089786  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116089797  Tubb4b; tubulin beta-4B chain [KO:K07375]
116089804  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116089825  C8g; complement component C8 gamma chain isoform X1 [KO:K03999]
116089856  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
116090044  Hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:5.6.1.10]
116090054  [KO:K03994]
116090075  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
116090105  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
116090151  Kif5c; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
116090221  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
116090323  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
116090342  [KO:K08738]
116090451  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
116090454  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
116090490  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
116090647  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
116090915  Il1a; interleukin-1 alpha [KO:K04383]
116090916  Il1b; interleukin-1 beta [KO:K04519]
116090968  Prnp; major prion protein [KO:K05634]
116091160  Csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
116091233  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
116091502  Tubb1; tubulin beta-1 chain [KO:K07375]
116091503  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
116091522  Psma7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
116091526  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
116091666  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
116092456  [KO:K02263]
116093212  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
116093378  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
116093388  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
116093578  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
116093624  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
116093830  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116094815  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116095068  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
116095468  C8b; complement component C8 beta chain isoform X1 [KO:K03998]
116095470  C8a; complement component C8 alpha chain isoform X1 [KO:K03997]
116095616  [KO:K03986]
116095820  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
116095903  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
116096011  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
116096012  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
116096453  [KO:K00416]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116096591  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
116096647  Psmb2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
116096943  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
116096967  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097436  Il6; interleukin-6 [KO:K05405]
116097517  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
116098287  Cav3; caveolin-3 [KO:K12959]
116098456  [KO:K07374]
116098557  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
116098581  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
116098598  Cav2; caveolin-2 isoform X1 [KO:K12958]
116098599  Cav1; caveolin-1 isoform X1 [KO:K06278]
116098636  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
116098735  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
116098773  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
116098897  [KO:K08738]
116098936  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
116098989  [KO:K02136]
116099029  [KO:K05862]
116099053  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
116099362  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116099482  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116099526  Tuba8; tubulin alpha-8 chain [KO:K07374]
116099610  [KO:K07374]
116099623  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
116099710  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116099794  [KO:K07374]
116099798  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116100325  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
116100436  [KO:K02270]
116100918  [KO:K02266]
116100960  [KO:K02273]
116101207  Ncf2; neutrophil cytosol factor 2 [KO:K08010]
116101239  Lamc1; laminin subunit gamma-1 [KO:K05635]
116101375  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
116101528  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
116101559  [KO:K02267]
116101752  Klc3; kinesin light chain 3 [KO:K10407]
116101900  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
116101936  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
116101988  [KO:K02267]
116102201  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
116102223  Grin2d; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
116102419  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116102591  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
116102829  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
116102887  [KO:K00415]
116102910  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116103294  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
116103302  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
116103309  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
116103322  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
116103359  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
116103373  Klc2; kinesin light chain 2 [KO:K10407]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116103476  Stip1; stress-induced-phosphoprotein 1 [KO:K09553]
116103484  [KO:K02273]
116103899  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
116104663  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
34682989  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
34682993  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
34682999  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
34683002  COX2; cytochrome c oxidase subunit II [KO:K02261]
34683004  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
34683005  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
34683006  COX3; cytochrome c oxidase subunit III [KO:K02262]
34683008  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
34683010  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
34683011  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
34683015  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
34683016  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
34683018  CYTB; cytochrome b [KO:K00412]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
  Authors
Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
  Journal
Expert Rev Mol Med 18:e5 (2016)
DOI:10.1017/erm.2016.8
Reference
PMID:25584786
  Authors
Goold R, McKinnon C, Tabrizi SJ
  Title
Prion degradation pathways: Potential for therapeutic intervention.
  Journal
Mol Cell Neurosci 66:12-20 (2015)
DOI:10.1016/j.mcn.2014.12.009
Reference
PMID:20889378
  Authors
Soto C, Satani N
  Title
The intricate mechanisms of neurodegeneration in prion diseases.
  Journal
Trends Mol Med 17:14-24 (2011)
DOI:10.1016/j.molmed.2010.09.001
Reference
PMID:27060771
  Authors
Mays CE, Soto C
  Title
The stress of prion disease.
  Journal
Brain Res 1648:553-560 (2016)
DOI:10.1016/j.brainres.2016.04.009
Reference
PMID:32565065
  Authors
Jones E, Mead S
  Title
Genetic risk factors for Creutzfeldt-Jakob disease.
  Journal
Neurobiol Dis 142:104973 (2020)
DOI:10.1016/j.nbd.2020.104973
Reference
PMID:18245809
  Authors
Kovacs GG, Budka H
  Title
Prion diseases: from protein to cell pathology.
  Journal
Am J Pathol 172:555-65 (2008)
DOI:10.2353/ajpath.2008.070442
Reference
PMID:15695097
  Authors
Campana V, Sarnataro D, Zurzolo C
  Title
The highways and byways of prion protein trafficking.
  Journal
Trends Cell Biol 15:102-11 (2005)
DOI:10.1016/j.tcb.2004.12.002
Reference
PMID:17051207
  Authors
Caughey B, Baron GS
  Title
Prions and their partners in crime.
  Journal
Nature 443:803-10 (2006)
DOI:10.1038/nature05294
Reference
PMID:11592845
  Authors
Chiesa R, Harris DA
  Title
Prion diseases: what is the neurotoxic molecule?
  Journal
Neurobiol Dis 8:743-63 (2001)
DOI:10.1006/nbdi.2001.0433
Reference
PMID:17085779
  Authors
Fasano C, Campana V, Zurzolo C
  Title
Prions: protein only or something more? Overview of potential prion cofactors.
  Journal
J Mol Neurosci 29:195-214 (2006)
DOI:10.1385/JMN:29:3:195
Reference
PMID:14705136
  Authors
Roucou X, Gains M, LeBlanc AC
  Title
Neuroprotective functions of prion protein.
  Journal
J Neurosci Res 75:153-61 (2004)
DOI:10.1002/jnr.10864
Reference
PMID:10398674
  Authors
Harris DA
  Title
Cellular biology of prion diseases.
  Journal
Clin Microbiol Rev 12:429-44 (1999)
Reference
PMID:15890824
  Authors
Novakofski J, Brewer MS, Mateus-Pinilla N, Killefer J, McCusker RH
  Title
Prion biology relevant to bovine spongiform encephalopathy.
  Journal
J Anim Sci 83:1455-76 (2005)
DOI:10.2527/2005.8361455x
Reference
PMID:27581199
  Authors
Peggion C, Bertoli A, Sorgato MC
  Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
  Journal
Biochem Biophys Res Commun 483:1148-1155 (2017)
DOI:10.1016/j.bbrc.2016.07.118
Reference
PMID:31618844
  Authors
Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
  Title
Prion Protein in Glioblastoma Multiforme.
  Journal
Int J Mol Sci 20:E5107 (2019)
DOI:10.3390/ijms20205107
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:30710214
  Authors
Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
  Title
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
  Journal
Mol Neurobiol 56:6035-6045 (2019)
DOI:10.1007/s12035-019-1505-6
Reference
PMID:23439666
  Authors
Song Z, Zhao D, Yang L
  Title
Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
DOI:10.1093/abbs/gmt014
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:29194372
  Authors
Hughes D, Halliday M
  Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
  Journal
Pathogens 6:63 (2017)
DOI:10.3390/pathogens6040063
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:29476642
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
  Journal
FEBS J 286:342-355 (2019)
DOI:10.1111/febs.14422
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:18420416
  Authors
Ferreiro E, Oliveira CR, Pereira CM
  Title
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
  Journal
Neurobiol Dis 30:331-42 (2008)
DOI:10.1016/j.nbd.2008.02.003
Reference
PMID:16844381
  Authors
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM
  Title
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
  Journal
Neurobiol Dis 23:669-78 (2006)
DOI:10.1016/j.nbd.2006.05.011
Reference
PMID:21980554
  Authors
Torres M, Encina G, Soto C, Hetz C
  Title
Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.
  Journal
Commun Integr Biol 4:258-61 (2011)
DOI:10.4161/cib.4.3.15019
Reference
PMID:25766616
  Authors
Ciechanover A, Kwon YT
  Title
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
  Journal
Exp Mol Med 47:e147 (2015)
DOI:10.1038/emm.2014.117
Reference
PMID:17466621
  Authors
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ
  Title
Disease-associated prion protein oligomers inhibit the 26S proteasome.
  Journal
Mol Cell 26:175-88 (2007)
DOI:10.1016/j.molcel.2007.04.001
Reference
PMID:10195903
  Authors
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
  Title
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
  Journal
Science 284:339-43 (1999)
DOI:10.1126/science.284.5412.339
Reference
PMID:14532116
  Authors
Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C
  Title
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
  Journal
EMBO J 22:5435-45 (2003)
DOI:10.1093/emboj/cdg537
Reference
PMID:31417367
  Authors
Zamponi E, Pigino GF
  Title
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
  Journal
Front Cell Neurosci 13:350 (2019)
DOI:10.3389/fncel.2019.00350
Reference
PMID:29261664
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
DOI:10.1371/journal.pone.0188340
Reference
PMID:21196165
  Authors
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
  Title
Understanding the neurospecificity of Prion protein signaling.
  Journal
Front Biosci (Landmark Ed) 16:169-86 (2011)
DOI:10.2741/3682
Reference
PMID:23479001
  Authors
Didonna A
  Title
Prion protein and its role in signal transduction.
  Journal
Cell Mol Biol Lett 18:209-30 (2013)
DOI:10.2478/s11658-013-0085-0
Reference
PMID:28507517
  Authors
Shah SZA, Zhao D, Hussain T, Yang L
  Title
The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
  Journal
Front Aging Neurosci 9:120 (2017)
DOI:10.3389/fnagi.2017.00120
Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
  Journal
J Biol Chem 280:1529-34 (2005)
DOI:10.1074/jbc.M410966200
Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
  Journal
Proc Natl Acad Sci U S A 102:886-91 (2005)
DOI:10.1073/pnas.0408612101
Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
DOI:10.1186/1750-1326-5-6
Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
DOI:10.1007/s12035-018-1193-7
Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
mcoc00190  Oxidative phosphorylation
mcoc03050  Proteasome
mcoc04020  Calcium signaling pathway
mcoc04140  Autophagy - animal
mcoc04141  Protein processing in endoplasmic reticulum
mcoc04142  Lysosome biogenesis
mcoc04144  Endocytosis
mcoc04210  Apoptosis
mcoc04330  Notch signaling pathway
mcoc04610  Complement and coagulation cascades
mcoc04668  TNF signaling pathway
KO pathway
ko05020   

DBGET integrated database retrieval system