KEGG   PATHWAY: mjv04530
Entry
mjv04530                    Pathway                                
Name
Tight junction - Manis javanica (Malayan pangolin)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mjv04530  Tight junction
mjv04530

Other DBs
GO: 0005923
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383250  RHOA; transforming protein RhoA [KO:K04513]
108383375  [KO:K07374]
108383453  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
108383873  [KO:K07374]
108384016  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
108384044  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
108384352  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
108384353  OCLN; occludin isoform X3 [KO:K06088]
108384506  POPDC1; popeye domain-containing protein 1 isoform X1 [KO:K21108]
108384584  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
108384793  RUNX1; runt-related transcription factor 1 isoform X2 [KO:K08367]
108384893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108384981  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
108385455  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
108385635  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
108385957  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
108385962  CLDN23; claudin-23 [KO:K06087]
108386155  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
108386659  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108386764  CGN; cingulin isoform X1 [KO:K06102]
108386817  JUN; transcription factor Jun [KO:K04448]
108386819  AFDN; afadin isoform X1 [KO:K05702]
108387031  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
108387363  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
108387488  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
108387496  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
108387557  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
108387631  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108387898  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108389064  NF2; merlin isoform X1 [KO:K16684]
108389250  [KO:K07374]
108389460  CLDN25; putative claudin-25 [KO:K06087]
108389902  RAB8B; ras-related protein Rab-8B [KO:K07902]
108390012  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108390518  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
108390646  MSN; moesin [KO:K05763]
108390850  TJP1; tight junction protein 1 isoform X1 [KO:K05701]
108390982  CLDN22; claudin-22 [KO:K06087]
108391302  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.39]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108391722  CLDN8; claudin-8 [KO:K06087]
108391723  CLDN17; claudin-17 [KO:K06087]
108391826  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
108392078  SYMPK; symplekin isoform X1 [KO:K06100]
108392084  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
108392183  ACTR3; actin-related protein 3 [KO:K18584]
108392300  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X7 [KO:K08018]
108392479  TUBA4B; LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
108392602  EZR; ezrin [KO:K08007]
108393012  [KO:K07374]
108393048  CLDN2; claudin-2 [KO:K06087]
108393089  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
108393268  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
108393451  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
108393544  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
108393653  CLDN11; claudin-11 [KO:K06087]
108393654  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
108393670  AMOTL1; angiomotin-like protein 1 isoform X4 [KO:K06104]
108394254  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
108394289  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
108394457  CLDN9; claudin-9 [KO:K06087]
108394463  CLDN6; claudin-6 [KO:K06087]
108394598  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
108394660  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
108395345  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
108395425  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
108395546  RAP1A; ras-related protein Rap-1A [KO:K04353]
108395822  CLDN15; claudin-15 [KO:K06087]
108395882  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
108395903  CLDN20; claudin-20 [KO:K06087]
108396272  TJP2; tight junction protein 2 isoform X1 [KO:K06098]
108396850  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
108396943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108397161  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
108397425  AMOT; angiomotin isoform X1 [KO:K16819]
108397753  MYH9; myosin-9 [KO:K10352]
108397917  MYH14; myosin-14 isoform X1 [KO:K10352]
108398139  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
108398142  MYL6; myosin light polypeptide 6 isoform X3 [KO:K12751]
108398246  MYH10; myosin-10 isoform X2 [KO:K10352]
108398341  CLDN3; claudin-3 [KO:K06087]
108398376  PCNA; proliferating cell nuclear antigen [KO:K04802]
108398443  CLDN4; claudin-4 [KO:K06087]
108398447  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X5 [KO:K08020]
108399306  CLDN18; claudin-18 isoform X1 [KO:K06087]
108399430  STK11; serine/threonine-protein kinase STK11 isoform X4 [KO:K07298] [EC:2.7.11.1]
108399501  ACTN4; alpha-actinin-4 isoform X8 [KO:K05699]
108399836  [KO:K06448]
108400560  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108400652  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
108400752  PATJ; inaD-like protein isoform X4 [KO:K06092]
108400898  MYH11; myosin-11 isoform X3 [KO:K10352]
108401061  JAM3; junctional adhesion molecule C [KO:K06785]
108401070  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X9 [KO:K06094]
108401094  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
108401154  PALS1; protein PALS1 isoform X1 [KO:K06091]
108401592  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108401657  EPB41L4B; band 4.1-like protein 4B isoform X4 [KO:K21111]
108401737  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
108402355  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108402362  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
108402609  CLDN1; claudin-1 isoform X2 [KO:K06087]
108403141  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
108403142  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X2 [KO:K05757]
108403327  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
108403637  DLG3; disks large homolog 3 isoform X5 [KO:K21098]
108403822  [KO:K07839]
108404092  CLDN12; claudin-12 [KO:K06087]
108405067  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X2 [KO:K12791]
108405702  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
108405988  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108406080  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108406145  SYNPO; synaptopodin isoform X1 [KO:K21112]
108406204  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
108406478  CLDN7; claudin-7 [KO:K06087]
108406669  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
108406773  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
108406860  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
108407034  RDX; radixin isoform X1 [KO:K05762]
108407171  F11R; junctional adhesion molecule A [KO:K06089]
108407219  [KO:K12757]
108407220  [KO:K12757]
108407295  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
108407529  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108408003  DLG1; disks large homolog 1 isoform X3 [KO:K12076]
108408149  CLDN14; claudin-14 [KO:K06087]
108408200  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X2 [KO:K07199]
108408205  RAB13; ras-related protein Rab-13 [KO:K06109]
108408223  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108408402  WAS; actin nucleation-promoting factor WAS isoform X3 [KO:K05747]
108408687  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
108409101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
108409166  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
108409616  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108409759  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
108410383  CLDN19; claudin-19 [KO:K06087]
140843024  [KO:K06087]
140845628  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
140848090  [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mjv04520  Adherens junction
mjv04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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