KEGG   PATHWAY: mjv04810
Entry
mjv04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Manis javanica (Malayan pangolin)
Class
Cellular Processes; Cell motility
Pathway map
mjv04810  Regulation of actin cytoskeleton
mjv04810

Other DBs
GO: 0030036
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383250  RHOA; transforming protein RhoA [KO:K04513]
108383337  INSRR; insulin receptor-related protein isoform X2 [KO:K05086] [EC:2.7.10.1]
108383340  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X3 [KO:K05767]
108383439  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
108383513  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108383641  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
108383643  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
108383914  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108383974  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
108384170  [KO:K05740]
108384279  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108384368  SPATA13; spermatogenesis-associated protein 13 isoform X8 [KO:K05769]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X3 [KO:K04369] [EC:2.7.12.2]
108385122  ITGA3; integrin alpha-3 [KO:K06482]
108385316  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108385678  KNG1; kininogen-1 isoform X1 [KO:K03898]
108385741  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385895  SSH1; protein phosphatase Slingshot homolog 1 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108385968  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
108386296  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
108386414  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
108386713  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
108387031  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
108387363  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
108387620  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108387898  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
108388194  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108388833  ITGB2; integrin beta-2 [KO:K06464]
108389506  FGF4; fibroblast growth factor 4 [KO:K04358]
108389685  CFL1; cofilin-1 isoform X1 [KO:K05765]
108390154  PDGFD; platelet-derived growth factor D isoform X3 [KO:K05450]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390646  MSN; moesin [KO:K05763]
108390684  ITGB6; integrin beta-6 [KO:K06589]
108390736  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X5 [KO:K13710]
108391143  [KO:K03994]
108391144  [KO:K03994]
108391169  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108391302  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.39]
108391341  FGF23; fibroblast growth factor 23 [KO:K22428]
108391499  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108391646  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
108391826  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
108391894  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108392183  ACTR3; actin-related protein 3 [KO:K18584]
108392259  WASL; actin nucleation-promoting factor WASL isoform X2 [KO:K23612]
108392407  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
108392553  PFN4; profilin-4 [KO:K05759]
108392602  EZR; ezrin [KO:K08007]
108392664  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108392980  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
108393043  FGF9; fibroblast growth factor 9 [KO:K04358]
108393051  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4 [KO:K00889] [EC:2.7.1.68]
108393093  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108393153  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108393155  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
108393230  ITGA9; integrin alpha-9 [KO:K06585]
108393271  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108393279  FGF20; fibroblast growth factor 20 [KO:K04358]
108393349  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
108393368  PDGFC; platelet-derived growth factor C isoform X5 [KO:K05450]
108393520  C7; complement component C7 isoform X1 [KO:K03996]
108393666  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X4 [KO:K12330]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108394026  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
108394254  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
108394258  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108394533  CRK; adapter molecule crk isoform X1 [KO:K04438]
108394598  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
108394626  FGF3; fibroblast growth factor 3 [KO:K04358]
108394631  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108394983  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108395351  PFN1; profilin-1 [KO:K05759]
108395451  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
108395520  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108395928  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
108395975  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
108396063  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
108396170  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
108396203  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
108396233  [KO:K05759]
108396329  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X3 [KO:K17457]
108396343  FGF5; fibroblast growth factor 5 [KO:K04358]
108396424  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
108396573  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108397051  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108397055  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
108397161  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
108397295  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108397399  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108397691  PXN; paxillin isoform X1 [KO:K05760]
108397753  MYH9; myosin-9 [KO:K10352]
108397792  FGF10; fibroblast growth factor 10 [KO:K04358]
108397917  MYH14; myosin-14 isoform X1 [KO:K10352]
108397962  EGFR; epidermal growth factor receptor isoform X6 [KO:K04361] [EC:2.7.10.1]
108398047  NRAS; GTPase NRas [KO:K07828]
108398120  BAIAP2; BAR/IMD domain-containing adapter protein 2 isoform X1 [KO:K05627]
108398246  MYH10; myosin-10 isoform X2 [KO:K10352]
108398346  LIMK1; LIM domain kinase 1 isoform X6 [KO:K05743] [EC:2.7.11.1]
108398432  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108398550  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
108398692  [KO:K03916]
108398761  VCL; vinculin isoform X1 [KO:K05700]
108398868  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
108398904  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
108399261  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
108399501  ACTN4; alpha-actinin-4 isoform X8 [KO:K05699]
108399649  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
108400295  RRAS; ras-related protein R-Ras isoform X2 [KO:K07829]
108400332  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
108400389  ITGA10; integrin alpha-10 isoform X3 [KO:K06586]
108400557  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
108400560  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108400639  ITGB4; integrin beta-4 [KO:K06525]
108400663  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
108400668  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
108400695  ITGAM; integrin alpha-M [KO:K06461]
108400786  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
108400898  MYH11; myosin-11 isoform X3 [KO:K10352]
108401068  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108401199  ITGA11; integrin alpha-11 [KO:K06587]
108401250  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
108401289  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
108401592  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108401794  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108402058  CFL2; cofilin-2 isoform X1 [KO:K05765]
108402114  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108402385  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
108402388  C8B; complement component C8 beta chain isoform X3 [KO:K03998]
108402439  FGF16; fibroblast growth factor 16 [KO:K04358]
108402614  INS; insulin [KO:K04526]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108403141  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
108403142  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X2 [KO:K05757]
108403283  C9; complement component C9 [KO:K04000]
108403296  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
108403502  ENAH; protein enabled homolog isoform X6 [KO:K05746]
108403623  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
108403645  ITGAD; integrin alpha-D isoform X3 [KO:K06594]
108403647  [KO:K06462]
108403732  RGCC; regulator of cell cycle RGCC [KO:K26108]
108403789  ABI2; abl interactor 2 isoform X1 [KO:K05751]
108403861  C6; complement component C6 [KO:K03995]
108404158  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
108404503  MYL11; myosin regulatory light chain 11 [KO:K12758]
108404603  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
108404758  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
108404891  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108405100  GSN; gelsolin isoform X1 [KO:K05768]
108405384  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
108405577  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108406371  PFN3; profilin-3 [KO:K05759]
108406564  WASF2; actin-binding protein WASF2 [KO:K05748]
108406634  SSH2; protein phosphatase Slingshot homolog 2 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108406636  GIT1; ARF GTPase-activating protein GIT1 isoform X4 [KO:K05737]
108406677  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108406701  PFN2; profilin-2 isoform X2 [KO:K05759]
108406805  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
108406838  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
108407034  RDX; radixin isoform X1 [KO:K05762]
108407058  FN1; fibronectin isoform X1 [KO:K05717]
108407219  [KO:K12757]
108407220  [KO:K12757]
108407359  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108407726  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
108408073  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
108408094  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
108408141  BRK1; protein BRICK1 [KO:K05752]
108408449  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
108408507  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
108408533  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
108408598  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
108408639  APC; adenomatous polyposis coli protein isoform X11 [KO:K02085]
108408988  CRKL; crk-like protein [KO:K04438]
108409101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
108409892  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
108409981  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
108410024  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108410087  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
108410150  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
118966805  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
118967667  [KO:K02833]
118967966  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
118970652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118970663  FGF6; fibroblast growth factor 6 [KO:K04358]
118971119  FGF19; fibroblast growth factor 19 [KO:K22603]
118972785  TMSB4X; thymosin beta-4 [KO:K05764]
118973114  FGF7; fibroblast growth factor 7 [KO:K04358]
140842982  [KO:K02833]
140843067  [KO:K02833]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mjv04010  MAPK signaling pathway
mjv04510  Focal adhesion
mjv04520  Adherens junction
KO pathway
ko04810   

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