KEGG   PATHWAY: mlk04530
Entry
mlk04530                    Pathway                                
Name
Tight junction - Mustela lutreola (European mink)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mlk04530  Tight junction
mlk04530

Other DBs
GO: 0005923
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131807367  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
131807580  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
131807708  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
131807732  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
131808017  PCNA; proliferating cell nuclear antigen [KO:K04802]
131808516  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
131808844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
131808860  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
131808912  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131808931  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
131809019  JUN; transcription factor Jun [KO:K04448]
131809076  PATJ; inaD-like protein isoform X1 [KO:K06092]
131809476  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
131810021  CGN; cingulin isoform X1 [KO:K06102]
131810049  CLDN19; claudin-19 isoform X1 [KO:K06087]
131810066  [KO:K04393]
131810068  RAP1A; ras-related protein Rap-1A [KO:K04353]
131810812  [KO:K07374]
131810835  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
131810837  [KO:K12757]
131810838  [KO:K12757]
131811099  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
131811115  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
131811241  [KO:K07374]
131811253  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
131811421  CLDN5; claudin-5 [KO:K06087]
131811594  [KO:K04393]
131811641  [KO:K04513]
131811692  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
131811851  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
131811869  NF2; merlin isoform X1 [KO:K16684]
131812388  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
131813113  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
131813236  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
131813260  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
131814122  CLDN10; claudin-10 isoform X1 [KO:K06087]
131814283  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
131814384  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
131814449  [KO:K06087]
131814505  [KO:K06448]
131814603  [KO:K06448]
131814621  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
131814674  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
131814685  [KO:K06448]
131814751  [KO:K07374]
131814879  [KO:K06448]
131814955  [KO:K06448]
131814987  [KO:K06448]
131814994  [KO:K06448]
131815006  [KO:K06448]
131815021  [KO:K06448]
131815038  [KO:K06448]
131815669  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
131815737  CLDN7; claudin-7 [KO:K06087]
131815770  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131816144  ACTG1; actin, cytoplasmic 2 [KO:K05692]
131816228  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
131816781  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
131817001  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
131817118  MYH10; myosin-10 isoform X1 [KO:K10352]
131817156  CTTN; src substrate cortactin isoform X1 [KO:K06106]
131817379  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
131817536  MYH14; myosin-14 isoform X1 [KO:K10352]
131818245  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
131818528  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
131818624  SYMPK; symplekin isoform X1 [KO:K06100]
131818796  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
131818799  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
131819147  CLDN15; claudin-15 isoform X1 [KO:K06087]
131819189  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
131819191  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
131819477  CLDN6; claudin-6 [KO:K06087]
131819614  CLDN4; claudin-4 [KO:K06087]
131819650  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
131819705  [KO:K07374]
131819713  CLDN3; claudin-3 [KO:K06087]
131819734  CLDN9; claudin-9 [KO:K06087]
131819826  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
131819940  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
131820091  MYH11; myosin-11 isoform X1 [KO:K10352]
131820100  ACTB; actin, cytoplasmic 1 [KO:K05692]
131820315  CLDN25; putative claudin-25 [KO:K06087]
131820528  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
131820538  CLDN22; claudin-22 [KO:K06087]
131820539  CLDN24; putative claudin-24 [KO:K06087]
131820564  CLDN23; claudin-23 [KO:K06087]
131820827  MSN; moesin [KO:K05763]
131821216  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
131821312  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
131821406  AMOT; angiomotin [KO:K16819]
131821720  WAS; actin nucleation-promoting factor WAS isoform X1 [KO:K05747]
131821809  CLDN2; claudin-2 isoform X1 [KO:K06087]
131821848  [KO:K06099]
131821908  [KO:K06099]
131822033  CLDN34; claudin-34 [KO:K06087]
131823185  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
131823297  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
131823389  CRB3; protein crumbs homolog 3 [KO:K06090]
131823426  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
131823455  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
131823635  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
131823691  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
131823928  RHOA; transforming protein RhoA [KO:K04513]
131824037  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
131824103  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
131824203  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
131824412  [KO:K07374]
131824425  [KO:K12757]
131824562  AMOTL2; angiomotin-like protein 2 [KO:K06104]
131824576  CLDN18; claudin-18 isoform X1 [KO:K06087]
131824604  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
131824691  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
131824726  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
131824728  CLDN1; claudin-1 [KO:K06087]
131824874  CLDN11; claudin-11 [KO:K06087]
131824877  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
131825279  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
131825300  CLDN8; claudin-8 [KO:K06087]
131825301  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
131825345  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
131825358  CLDN14; claudin-14 [KO:K06087]
131825386  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
131825981  CLDN17; claudin-17 [KO:K06087]
131826035  [KO:K18584]
131826440  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
131826940  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
131827429  [KO:K07374]
131827445  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
131827465  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
131827746  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
131827971  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
131828723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131829353  CLDN12; claudin-12 [KO:K06087]
131829662  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
131829962  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
131829971  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
131830528  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
131831160  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
131831692  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
131831772  SYNPO; synaptopodin isoform X1 [KO:K21112]
131831843  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
131832007  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
131832034  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
131832215  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
131832249  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
131832318  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
131832321  OCLN; occludin [KO:K06088]
131832665  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
131833155  [KO:K04393]
131833346  AFDN; afadin isoform X1 [KO:K05702]
131833415  EZR; ezrin isoform X1 [KO:K08007]
131833436  CLDN20; claudin-20 [KO:K06087]
131833561  BVES; blood vessel epicardial substance [KO:K21108]
131833720  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
131833762  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
131833907  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
131834013  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
131835540  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
131835552  RDX; radixin [KO:K05762]
131835702  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
131835761  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
131835843  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
131835851  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
131835897  RAB8B; ras-related protein Rab-8B [KO:K07902]
131836704  PALS1; protein PALS1 isoform X1 [KO:K06091]
131836725  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
131837022  [KO:K07839]
131838055  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
131838306  ITGB1; integrin beta-1 [KO:K05719]
131838311  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
131838335  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
131838541  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
131838608  MYL6B; myosin light chain 6B [KO:K12751]
131838609  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
131838802  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
131838804  [KO:K07374]
131838805  [KO:K07374]
131838806  [KO:K07374]
131838812  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
131839038  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
131839085  AMOTL1; angiomotin-like protein 1 [KO:K06104]
131839417  MYH9; myosin-9 [KO:K10352]
131839931  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
131840212  ACTR2; actin-related protein 2 [KO:K17260]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mlk04520  Adherens junction
mlk04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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