KEGG   PATHWAY: mlk04810
Entry
mlk04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Mustela lutreola (European mink)
Class
Cellular Processes; Cell motility
Pathway map
mlk04810  Regulation of actin cytoskeleton
mlk04810

Other DBs
GO: 0030036
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131807301  PFN4; profilin-4 [KO:K05759]
131807351  CYRIA; CYFIP-related Rac1 interactor A isoform X1 [KO:K27976]
131807367  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
131807708  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
131807732  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
131808024  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
131808081  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
131808792  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
131808865  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
131808912  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131809015  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131809234  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
131809574  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
131809906  C8B; complement component C8 beta chain [KO:K03998]
131809957  C8A; complement component C8 alpha chain [KO:K03997]
131810028  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
131810066  [KO:K04393]
131810162  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
131810307  NRAS; GTPase NRas isoform X1 [KO:K07828]
131810405  WASF2; LOW QUALITY PROTEIN: actin-binding protein WASF2 [KO:K05748]
131810524  [KO:K07828]
131810819  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
131810837  [KO:K12757]
131810838  [KO:K12757]
131810869  PXN; paxillin isoform X1 [KO:K05760]
131811098  CRKL; crk-like protein [KO:K04438]
131811171  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
131811253  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
131811462  [KO:K05750]
131811594  [KO:K04393]
131811641  [KO:K04513]
131811692  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
131811758  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131811804  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
131811851  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
131812024  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
131812146  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
131812225  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
131812242  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
131812289  GSN; gelsolin isoform X1 [KO:K05768]
131812383  C5; complement C5 [KO:K03994]
131812389  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
131812504  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
131813085  C8G; complement component C8 gamma chain [KO:K03999]
131813113  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
131813574  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
131813743  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
131813822  FGF9; fibroblast growth factor 9 [KO:K04358]
131814017  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
131814083  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
131814284  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
131814328  ENAH; protein enabled homolog isoform X1 [KO:K05746]
131814674  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
131814757  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
131814797  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
131814907  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
131815063  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131815704  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
131815755  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
131815757  CFL1; cofilin-1 isoform X1 [KO:K05765]
131815789  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
131815914  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
131816001  ITGB3; integrin beta-3 [KO:K06493]
131816011  [KO:K05752]
131816016  PFN1; profilin-1 [KO:K05759]
131816057  CRK; adapter molecule crk isoform X1 [KO:K04438]
131816144  ACTG1; actin, cytoplasmic 2 [KO:K05692]
131816286  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
131816316  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
131816419  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
131816536  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
131816825  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
131816925  ITGAE; integrin alpha-E [KO:K06524]
131816959  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
131816967  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
131817118  MYH10; myosin-10 isoform X1 [KO:K10352]
131817353  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
131817465  RRAS; ras-related protein R-Ras [KO:K07829]
131817477  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
131817507  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131817536  MYH14; myosin-14 isoform X1 [KO:K10352]
131817733  INS; insulin isoform X1 [KO:K04526]
131817944  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
131817960  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
131818207  [KO:K05764]
131818337  HRAS; GTPase HRas isoform X1 [KO:K02833]
131818352  FGF21; fibroblast growth factor 21 [KO:K22429]
131818622  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
131818799  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
131818802  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
131819189  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
131819191  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
131819264  MYL11; myosin regulatory light chain 11 isoform X1 [KO:K12758]
131819299  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
131819303  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
131819467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
131819471  ITGAX; integrin alpha-X [KO:K06462]
131819539  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
131819566  MYL10; myosin regulatory light chain 10 [KO:K12756]
131819629  ITGAD; integrin alpha-D isoform X1 [KO:K06594]
131819692  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
131819729  MYL5; myosin light chain 5 [KO:K12753]
131819826  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
131819956  FGF5; fibroblast growth factor 5 [KO:K04358]
131820091  MYH11; myosin-11 isoform X1 [KO:K10352]
131820100  ACTB; actin, cytoplasmic 1 [KO:K05692]
131820131  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131820615  FGF20; fibroblast growth factor 20 [KO:K04358]
131820646  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
131820700  [KO:K05764]
131820748  TMSB4X; thymosin beta-4 [KO:K05764]
131820827  MSN; moesin [KO:K05763]
131821123  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
131821130  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
131821335  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
131821366  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
131821509  FGF16; fibroblast growth factor 16 [KO:K04358]
131821957  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
131822214  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
131822739  FGF19; fibroblast growth factor 19 [KO:K22603]
131822740  FGF4; fibroblast growth factor 4 [KO:K04358]
131822741  FGF3; fibroblast growth factor 3 [KO:K04358]
131823154  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
131823200  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
131823296  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
131823312  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
131823393  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
131823580  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
131823754  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
131823817  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
131823928  RHOA; transforming protein RhoA [KO:K04513]
131824031  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131824203  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
131824215  BRK1; protein BRICK1 [KO:K05752]
131824239  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131824375  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
131824425  [KO:K12757]
131824584  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
131824589  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131824634  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
131824645  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
131824683  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
131824751  KNG1; kininogen-1 isoform X1 [KO:K03898]
131824847  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131825004  PFN2; profilin-2 isoform X1 [KO:K05759]
131825301  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
131825470  ITGB2; integrin beta-2 [KO:K06464]
131825586  [KO:K05764]
131826035  [KO:K18584]
131826363  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
131826398  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
131826555  [KO:K05764]
131826886  [KO:K05769]
131826887  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
131826940  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
131826966  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
131826998  ITGAV; integrin alpha-V [KO:K06487]
131827010  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
131827022  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
131827091  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
131827098  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
131827176  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
131827465  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
131827486  FN1; fibronectin isoform X1 [KO:K05717]
131827509  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
131827546  ABI2; abl interactor 2 isoform X1 [KO:K05751]
131827856  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
131828225  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
131828696  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
131828809  VCL; vinculin isoform X1 [KO:K05700]
131828887  [KO:K05764]
131829017  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
131829150  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131829316  EGF; pro-epidermal growth factor [KO:K04357]
131829444  SCIN; scinderin [KO:K05768]
131829482  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
131829555  [KO:K05764]
131829700  WASL; actin nucleation-promoting factor WASL [KO:K23612]
131829812  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
131829849  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
131829971  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
131830281  FGF8; fibroblast growth factor 8 [KO:K04358]
131830329  [KO:K05752]
131830370  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
131830520  [KO:K05764]
131830547  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
131830605  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
131831363  PFN3; profilin-3 [KO:K05759]
131831687  C9; complement component C9 [KO:K04000]
131831691  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
131831697  C7; complement component C7 [KO:K03996]
131831699  C6; complement component C6 [KO:K03995]
131831722  FGF10; fibroblast growth factor 10 [KO:K04358]
131831727  ITGA2; integrin alpha-2 [KO:K06481]
131831728  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
131831763  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
131831831  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
131831909  FGF18; fibroblast growth factor 18 [KO:K04358]
131831964  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
131832182  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
131832196  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
131832309  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131832371  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
131832374  F2R; proteinase-activated receptor 1 [KO:K03914]
131832532  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
131833155  [KO:K04393]
131833415  EZR; ezrin isoform X1 [KO:K08007]
131833514  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
131834291  FGF17; fibroblast growth factor 17 [KO:K04358]
131834448  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
131834784  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
131835365  [KO:K05764]
131835552  RDX; radixin [KO:K05762]
131835568  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
131835734  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
131835957  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
131835979  ITGA11; integrin alpha-11 [KO:K06587]
131836062  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
131836104  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
131836265  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131836460  CFL2; cofilin-2 [KO:K05765]
131836536  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
131836725  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
131836961  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
131837056  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131837245  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
131838003  [KO:K04347]
131838170  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
131838241  ITGA8; integrin alpha-8 [KO:K06584]
131838306  ITGB1; integrin beta-1 [KO:K05719]
131838416  FGF23; fibroblast growth factor 23 [KO:K22428]
131838449  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
131838548  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
131838635  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
131838652  NCKAP1L; nck-associated protein 1-like [KO:K05750]
131838659  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
131838703  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
131838926  KRAS; GTPase KRas isoform X1 [KO:K07827]
131839209  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
131839417  MYH9; myosin-9 [KO:K10352]
131839444  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
131839489  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
131839915  FGF6; fibroblast growth factor 6 [KO:K04358]
131840212  ACTR2; actin-related protein 2 [KO:K17260]
131840354  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
131840500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131840593  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mlk04010  MAPK signaling pathway
mlk04510  Focal adhesion
mlk04520  Adherens junction
KO pathway
ko04810   

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