KEGG   PATHWAY: mmu03013
Entry
mmu03013                    Pathway                                
Name
Nucleocytoplasmic transport - Mus musculus (house mouse)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
mmu03013  Nucleocytoplasmic transport
mmu03013

Other DBs
GO: 0050658
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100041953  Sap18b; Sin3-associated polypeptide 18B [KO:K14324]
100042165  Thoc2l; THO complex subunit 2-like [KO:K12879]
100043292  Alyreffm10; Aly/REF export factor family member 10 [KO:K12881]
100861880  Alyreffm11; Aly/REF export factor family member 11 [KO:K12881]
102640040  Gm11971; predicted gene 11971 [KO:K12160]
103468  Nup107; nucleoporin 107 [KO:K14301]
103573  Xpo1; exportin 1 [KO:K14290]
107829  Thoc5; THO complex 5 [KO:K13174]
107939  Pom121; nuclear pore membrane protein 121 [KO:K14316]
108989  Tpr; translocated promoter region, nuclear basket protein [KO:K09291]
110379  Sec13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
110750  Cse1l; chromosome segregation 1 like [KO:K18423]
114671  Semp2l2b; SUMO/sentrin specific peptidase 2-like 2B [KO:K03345] [EC:3.4.22.68]
13627  Eef1a1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]
13628  Eef1a2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231]
13680  Ddx19a; DEAD box helicase 19a [KO:K18655] [EC:5.6.2.7]
16211  Kpnb1; karyopherin subunit beta 1 [KO:K14293]
16646  Kpna1; karyopherin subunit alpha 1 [KO:K23940]
16647  Kpna2; karyopherin subunit alpha 2 [KO:K15043]
16648  Kpna3; karyopherin subunit alpha 3 [KO:K23583]
16649  Kpna4; karyopherin subunit alpha 4 [KO:K23583]
16650  Kpna6; karyopherin subunit alpha 6 [KO:K15042]
170722  Nxf7; nuclear RNA export factor 7 [KO:K14284]
170762  Nup155; nucleoporin 155 [KO:K14312]
170930  Sumo2; small ubiquitin-like modifier 2 [KO:K12160]
17149  Magoh; mago homolog, exon junction complex core component [KO:K12877]
18141  Nup50; nucleoporin 50 [KO:K14295]
18226  Nup62; nucleoporin 62 [KO:K14306]
18949  Pnn; pinin [KO:K13114]
19069  Nup88; nucleoporin 88 [KO:K14318]
192160  Casc3; exon junction complex subunit [KO:K14323]
192170  Eif4a3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
19384  Ran; RAN, member RAS oncogene family [KO:K07936]
19386  Ranbp2; RAN binding protein 2 [KO:K12172] [EC:2.3.2.-]
19387  Rangap1; RAN GTPase activating protein 1 [KO:K14319]
19428  Rasl2-9; RAS-like, family 2, locus 9 [KO:K07936]
195236  Pom121l2; POM121 transmembrane nucleoporin like 2 [KO:K14316]
19704  Upf1; UPF1 RNA helicase and ATPase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
19826  Rnps1; RNA binding protein with serine rich domain 1 [KO:K14325]
20220  Sap18; Sin3-associated polypeptide 18 [KO:K14324]
20610  Sumo3; small ubiquitin-like modifier 3 [KO:K12160]
212999  Tnpo2; transportin 2 (importin 3, karyopherin beta 2b) [KO:K18727]
21681  Alyref; Aly/REF export factor [KO:K12881]
218210  Nup153; nucleoporin 153 [KO:K14296]
22196  Ube2i; ubiquitin-conjugating enzyme E2I [KO:K10577]
22218  Sumo1; small ubiquitin-like modifier 1 [KO:K12160]
223921  Aaas; achalasia, adrenocortical insufficiency, alacrimia [KO:K14320]
225160  Thoc1; THO complex 1 [KO:K12878]
226432  Ipo9; importin 9 [KO:K20224]
226747  Ahctf1; AT hook containing transcription factor 1 [KO:K25129]
227699  Nup188; nucleoporin 188 [KO:K14311]
227720  Nup214; nucleoporin 214 [KO:K14317]
230673  Ipo13; importin 13 [KO:K25202]
231042  Nup42; nucleoporin 42 [KO:K14321]
231201  Semp2l2a; SUMO/sentrin specific peptidase 2-like 2A [KO:K03345] [EC:3.4.22.68]
233726  Ipo7; importin 7 [KO:K20223]
234733  Ddx19b; DEAD box helicase 19b [KO:K18655] [EC:5.6.2.7]
234865  Nup133; nucleoporin 133 [KO:K14300]
237082  Nxt2; nuclear transport factor 2-like export factor 2 [KO:K14285]
238799  Tnpo1; transportin 1 [KO:K18752]
245610  Nxf3; nuclear RNA export factor 3 [KO:K14284]
269113  Nup54; nucleoporin 54 [KO:K14308]
269966  Nup98; nucleoporin 98 [KO:K14297]
320727  Ipo8; importin 8 [KO:K18755]
320938  Tnpo3; transportin 3 [KO:K15436]
326622  Upf2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
331401  Thoc2; THO complex 2 [KO:K12879]
381686  Kpna7; karyopherin subunit alpha 7 [KO:K15043]
386612  Thoc6; THO complex 6 [KO:K13175]
408191  Semp2l1; SUMO/sentrin specific peptidase 2-like 1 [KO:K03345] [EC:3.4.22.68]
408192  Gm9839; predicted gene 9839 [KO:K03345] [EC:3.4.22.68]
433702  Ncbp1; nuclear cap binding protein subunit 1 [KO:K12882]
434050  Gm5576; predicted pseudogene 5576 [KO:K13025] [EC:5.6.2.7]
434080  Eif4a3l2; eukaryotic translation initiation factor 4A3 like 2 [KO:K13025] [EC:5.6.2.7]
445007  Nup85; nucleoporin 85 [KO:K14304]
51796  Srrm1; serine/arginine repetitive matrix 1 [KO:K13171]
53319  Nxf1; nuclear RNA export factor 1 [KO:K14284]
53817  Ddx39b; DEAD box helicase 39b [KO:K12812] [EC:5.6.2.7]
54563  Nup210; nucleoporin 210 [KO:K14314]
56009  Alyref2; Aly/REF export factor 2 [KO:K12881]
56215  Acin1; apoptotic chromatin condensation inducer 1 [KO:K12875]
56488  Nxt1; NTF2-related export protein 1 [KO:K14285]
56698  Phax; phosphorylated adaptor for RNA export [KO:K14291]
57258  Xpo4; exportin 4 [KO:K25203]
59015  Nup160; nucleoporin 160 [KO:K14303]
60365  Rbm8a; RNA binding motif protein 8a [KO:K12876]
65246  Xpo7; exportin 7 [KO:K18460]
66011  Ranbp17; RAN binding protein 17 [KO:K24115]
66069  Snupn; snurportin 1 [KO:K13151]
66231  Thoc7; THO complex 7 [KO:K13176]
66441  Magohb; mago homolog B, exon junction complex core component [KO:K12877]
66679  Rae1; ribonucleic acid export 1 [KO:K14298]
668137  Eif4a3l1; eukaryotic translation initiation factor 4A3 like 1 [KO:K13025] [EC:5.6.2.7]
67031  Upf3a; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
67878  Tmem33; transmembrane protein 33 [KO:K20724]
68092  Ncbp2; nuclear cap binding protein subunit 2 [KO:K12883]
68134  Upf3b; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
69482  Nup35; nucleoporin 35 [KO:K14313]
69736  Nup37; nucleoporin 37 [KO:K14302]
69912  Nup43; nucleoporin 43 [KO:K14305]
70572  Ipo5; importin 5 [KO:K20222]
70699  Nup205; nucleoporin 205 [KO:K14310]
71805  Nup93; nucleoporin 93 [KO:K14309]
71844  Nup58; nucleoporin 58 [KO:K14307]
72124  Seh1l; SEH1-like (S. cerevisiae [KO:K14299]
72322  Xpo5; exportin 5 [KO:K14289]
72787  Ndc1; NDC1 transmembrane nucleoporin [KO:K14315]
73192  Xpot; exportin, tRNA (nuclear export receptor for tRNAs) [KO:K14288]
73666  Thoc3; THO complex 3 [KO:K12880]
74204  Xpo6; exportin 6 [KO:K25204]
74412  Gle1; GLE1 RNA export mediator [KO:K18723]
75471  1700009N14Rik; RIKEN cDNA 1700009N14 gene [KO:K07936]
75751  Ipo4; importin 4 [KO:K20221]
75826  Senp2; SUMO/sentrin specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
76582  Ipo11; importin 11 [KO:K25201]
77595  Nup210l; nucleoporin 210-like [KO:K14314]
78428  Pym1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
83454  Nxf2; nuclear RNA export factor 2 [KO:K14284]
97112  Nmd3; NMD3 ribosome export adaptor [KO:K07562]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
mmu03015  mRNA surveillance pathway
KO pathway
ko03013   

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