KEGG   PATHWAY: mthb04662
Entry
mthb04662                   Pathway                                
Name
B cell receptor signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
Pathway map
mthb04662  B cell receptor signaling pathway
mthb04662

Other DBs
GO: 0050853
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126929669  [KO:K04371] [EC:2.7.11.24]
126930434  [KO:K05697] [EC:3.1.3.48]
126930824  [KO:K07828]
126931572  [KO:K07827]
126932568  [KO:K03084] [EC:3.1.3.86]
126933534  [KO:K03099]
126934067  [KO:K06268]
126934266  [KO:K12362]
126935021  [KO:K15909] [EC:3.1.3.86]
126935358  [KO:K04735]
126935856  [KO:K06508]
126935869  [KO:K02833]
126936564  [KO:K19831]
126936911  [KO:K05730]
126937655  [KO:K05855] [EC:2.7.10.2]
126937786  [KO:K06268]
126938082  [KO:K06504]
126939124  [KO:K07861]
126939255  [KO:K04364]
126939537  [KO:K06507]
126941438  [KO:K07369] [EC:3.4.22.-]
126941512  [KO:K04446]
126941789  [KO:K06506]
126941883  [KO:K06467]
126942032  [KO:K04456] [EC:2.7.11.1]
126942055  [KO:K02581]
126942202  [KO:K02649]
126942510  [KO:K05730]
126942673  [KO:K04369] [EC:2.7.12.2]
126943096  [KO:K04456] [EC:2.7.11.1]
126943198  [KO:K06512]
126943208  [KO:K06512]
126943234  [KO:K07368]
126943320  [KO:K06512]
126943321  [KO:K06512]
126943324  [KO:K06512]
126943325  [KO:K06512]
126943330  [KO:K06512]
126943331  [KO:K06512]
126943334  [KO:K06512]
126943961  [KO:K05859] [EC:3.1.4.11]
126944052  [KO:K17333]
126944386  [KO:K19662] [EC:2.7.11.13]
126944439  [KO:K06465]
126944456  [KO:K04371] [EC:2.7.11.24]
126945470  [KO:K07210]
126945989  [KO:K07370] [EC:2.7.10.2]
126947557  [KO:K00922] [EC:2.7.1.153]
126947777  [KO:K05730]
126948170  [KO:K00922] [EC:2.7.1.153]
126949054  [KO:K04366] [EC:2.7.11.1]
126949098  [KO:K04012]
126949239  [KO:K03083] [EC:2.7.11.26]
126950508  [KO:K04392]
126951498  [KO:K07367]
126952407  [KO:K05872]
126952893  [KO:K00922] [EC:2.7.1.153]
126954326  [KO:K04392]
126954988  [KO:K04348] [EC:3.1.3.16]
126955215  [KO:K12229]
126955390  [KO:K02580]
126955392  [KO:K26239]
126956531  [KO:K02649]
126957976  [KO:K04368] [EC:2.7.12.2]
126958499  [KO:K03099]
126958643  [KO:K19831]
126959170  [KO:K04734]
126959416  [KO:K04456] [EC:2.7.11.1]
126959543  [KO:K04379]
126960750  [KO:K07209] [EC:2.7.11.10]
126961061  [KO:K08890] [EC:2.7.10.2]
126961264  [KO:K04348] [EC:3.1.3.16]
126961422  [KO:K02649]
126961723  [KO:K05854] [EC:2.7.10.2]
126962070  [KO:K12230]
126962081  [KO:K07371]
126962430  [KO:K04348] [EC:3.1.3.16]
126962798  [KO:K04448]
126963067  [KO:K04467] [EC:2.7.11.10]
126963767  [KO:K07860]
126964374  [KO:K17332]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12461567
  Authors
Niiro H, Clark EA.
  Title
Regulation of B-cell fate by antigen-receptor signals.
  Journal
Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955
Reference
PMID:10358768
  Authors
Kurosaki T.
  Title
Genetic analysis of B cell antigen receptor signaling.
  Journal
Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555
Reference
PMID:15886119
  Authors
Nitschke L.
  Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
  Journal
Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005
Reference
PMID:15752555
  Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
  Title
Complement: central to innate immunity and bridging to adaptive responses.
  Journal
Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010
Reference
PMID:12033741
  Authors
Kurosaki T.
  Title
Regulation of B-cell signal transduction by adaptor proteins.
  Journal
Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801
Reference
PMID:15364057
  Authors
Nitschke L, Tsubata T.
  Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
  Journal
Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002
Reference
PMID:15771577
  Authors
Jumaa H, Hendriks RW, Reth M.
  Title
B cell signaling and tumorigenesis.
  Journal
Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606
Reference
PMID:15886112
  Authors
Rickert RC.
  Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
  Journal
Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001
Reference
PMID:15457440
  Authors
Zouali M, Sarmay G
  Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
  Journal
Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487
Reference
PMID:15322145
  Authors
Chiles TC.
  Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
  Journal
J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901
Reference
PMID:15626471
  Authors
Allam A, Marshall AJ
  Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
  Journal
Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019
Reference
PMID:12119152
  Authors
Gold MR
  Title
To make antibodies or not: signaling by the B-cell antigen receptor.
  Journal
Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X
Reference
PMID:9697839
  Authors
Fu C, Turck CW, Kurosaki T, Chan AC
  Title
BLNK: a central linker protein in B cell activation.
  Journal
Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9
Reference
PMID:11163197
  Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
  Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
  Journal
Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0
Reference
PMID:18086859
  Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
  Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
  Journal
J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379
Related
pathway
mthb04010  MAPK signaling pathway
mthb04020  Calcium signaling pathway
mthb04064  NF-kappa B signaling pathway
mthb04120  Ubiquitin mediated proteolysis
mthb04151  PI3K-Akt signaling pathway
mthb04610  Complement and coagulation cascades
mthb04810  Regulation of actin cytoskeleton
KO pathway
ko04662   

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