KEGG   PATHWAY: mthb04151
Entry
mthb04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mthb04151  PI3K-Akt signaling pathway
mthb04151

Other DBs
GO: 0043491
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126954925  pro-epidermal growth factor isoform X1 [KO:K04357]
126934085  protransforming growth factor alpha isoform X1 [KO:K08774]
126954920  proepiregulin [KO:K09784]
126954907  amphiregulin [KO:K09782]
126957258  LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
126954986  fibroblast growth factor 2 [KO:K18497]
126942993  fibroblast growth factor 22 [KO:K04358]
126962737  fibroblast growth factor 8 isoform X1 [KO:K04358]
126931752  fibroblast growth factor 6 [KO:K04358]
126956981  fibroblast growth factor 18 [KO:K04358]
126957199  fibroblast growth factor 10 [KO:K04358]
126946335  fibroblast growth factor 16 [KO:K04358]
126958707  fibroblast growth factor 7 [KO:K04358]
126940532  fibroblast growth factor 9 [KO:K04358]
126935967  fibroblast growth factor 3 [KO:K04358]
126935973  fibroblast growth factor 4 [KO:K04358]
126960920  fibroblast growth factor 20 [KO:K04358]
126961295  fibroblast growth factor 17 isoform X1 [KO:K04358]
126935968  fibroblast growth factor 19 [KO:K22603]
126943598  fibroblast growth factor 21 [KO:K22429]
126931744  fibroblast growth factor 23 [KO:K22428]
126930848  beta-nerve growth factor [KO:K02582]
126934686  brain-derived neurotrophic factor isoform X1 [KO:K04355]
126930453  neurotrophin-3 isoform X1 [KO:K04356]
126943596  neurotrophin-4 [KO:K12457]
126935873  insulin isoform X1 [KO:K04526]
126931779  insulin-like growth factor I isoform X1 [KO:K05459]
126935883  insulin-like growth factor II [KO:K13769]
126950578  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126963759  platelet-derived growth factor subunit B [KO:K17386]
126936264  platelet-derived growth factor D isoform X1 [KO:K05450]
126954312  platelet-derived growth factor C [KO:K05450]
126929640  macrophage colony-stimulating factor 1 [KO:K05453]
126929998  kit ligand isoform X1 [KO:K05461]
126943138  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
126952424  vascular endothelial growth factor A isoform X1 [KO:K05448]
126935608  vascular endothelial growth factor B isoform X1 [KO:K16858]
126959573  placenta growth factor isoform X1 [KO:K16859]
126955710  vascular endothelial growth factor C isoform X1 [KO:K05449]
126946911  vascular endothelial growth factor D isoform X1 [KO:K05449]
126949900  hepatocyte growth factor isoform X1 [KO:K05460]
126961624  angiopoietin-1 isoform X1 [KO:K05465]
126961064  angiopoietin-2 isoform X1 [KO:K05466]
126964222  angiopoietin-4 isoform X1 [KO:K05467]
126942796  ephrin-A2 [KO:K05462]
126957121  ephrin-A5 isoform X1 [KO:K05462]
126934418  ephrin-A4 isoform X1 [KO:K05462]
126934582  ephrin-A3 isoform X1 [KO:K05462]
126934657  ephrin-A1 [KO:K05462]
126956073  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
126942809  neurturin [KO:K25414]
126960840  artemin isoform X1 [KO:K25415]
126942793  persephin [KO:K25416]
126950202  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126938415  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
126931198  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
126932508  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
126961189  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
126962662  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126955560  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
126956321  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
126939872  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126948042  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
126937627  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126959327  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
126954734  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126956582  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126956584  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126954735  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
126940719  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
126940714  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126956306  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
126954733  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126951204  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126937984  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
126956768  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
126962192  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
126939255  growth factor receptor-bound protein 2 [KO:K04364]
126933534  son of sevenless homolog 1 isoform X1 [KO:K03099]
126958499  son of sevenless homolog 2 isoform X1 [KO:K03099]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126932885  insulin receptor substrate 1 [KO:K16172]
126955690  toll-like receptor 2 [KO:K10159]
126936830  toll-like receptor 4 isoform X1 [KO:K10160]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126937655  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
126944439  B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
126962070  phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
126939474  growth hormone variant [KO:K05438]
126939475  growth hormone variant-like [KO:K05438]
126939476  LOW QUALITY PROTEIN: somatotropin-like [KO:K05438]
126939559  somatotropin isoform X1 [KO:K05438]
126939561  somatotropin-like [KO:K05438]
126939562  somatotropin-like isoform X1 [KO:K05438]
126939566  growth hormone variant-like [KO:K05438]
126953311  prolactin isoform X1 [KO:K05439]
126963983  oncostatin-M [KO:K05418]
126955754  interleukin-2 [KO:K05429]
126956031  interleukin-3 [KO:K04736]
126950025  interleukin-6 isoform X1 [KO:K05405]
126956021  interleukin-4 isoform X1 [KO:K05430]
126961637  interleukin-7 [KO:K05431]
126937598  interferon alpha-14 [KO:K05414]
126937600  interferon alpha-4-like [KO:K05414]
126937601  interferon alpha-17 [KO:K05414]
126937602  interferon alpha-17-like [KO:K05414]
126937603  interferon alpha-17-like [KO:K05414]
126937604  interferon alpha-17-like [KO:K05414]
126937605  LOW QUALITY PROTEIN: interferon alpha-10-like [KO:K05414]
126937606  interferon alpha-10-like [KO:K05414]
126937607  interferon alpha-1/13-like [KO:K05414]
126937608  interferon alpha-1/13 [KO:K05414]
126937609  interferon alpha-1/13-like [KO:K05414]
126937610  interferon alpha-6 [KO:K05414]
126937611  interferon alpha-4 [KO:K05414]
126937612  interferon alpha-8 [KO:K05414]
126937613  interferon alpha-2 [KO:K05414]
126937615  interferon alpha-21 [KO:K05414]
126947451  interferon alpha-10-like [KO:K05414]
126937702  interferon beta [KO:K05415]
126950416  erythropoietin isoform X1 [KO:K05437]
126938630  granulocyte colony-stimulating factor [KO:K05423]
126956470  growth hormone receptor isoform X1 [KO:K05080]
126956686  prolactin receptor [KO:K05081]
126956444  oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
126962923  interleukin-2 receptor subunit alpha [KO:K05068]
126963717  interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
126946182  cytokine receptor common subunit gamma isoform X1 [KO:K05070]
126946851  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
126947139  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
126934004  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
126944434  interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
126956291  interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
126951662  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
126951665  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
126942618  erythropoietin receptor [KO:K05079]
126959228  granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
126935739  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
126937558  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
126942179  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
126949926  collagen alpha-2(I) chain isoform X1 [KO:K06236]
126939864  collagen alpha-1(I) chain isoform X1 [KO:K06236]
126930148  collagen alpha-1(II) chain isoform X1 [KO:K19719]
126932884  collagen alpha-4(IV) chain isoform X1 [KO:K06237]
126932960  collagen alpha-3(IV) chain isoform X1 [KO:K06237]
126946614  collagen alpha-6(IV) chain isoform X1 [KO:K06237]
126946615  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
126940592  collagen alpha-1(IV) chain [KO:K06237]
126940593  collagen alpha-2(IV) chain [KO:K06237]
126932624  collagen alpha-3(VI) chain [KO:K06238]
126950596  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
126951507  collagen alpha-1(VI) chain [KO:K06238]
126947062  collagen alpha-5(VI) chain [KO:K06238]
126947078  collagen alpha-6(VI) chain [KO:K06238]
126947094  collagen alpha-4(VI) chain-like [KO:K06238]
126953938  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
126964093  collagen alpha-3(IX) chain [KO:K08131]
126959408  collagen alpha-2(IX) chain [KO:K08131]
126940995  laminin subunit alpha-1 isoform X1 [KO:K05637]
126953024  laminin subunit alpha-2 isoform X1 [KO:K05637]
126941333  laminin subunit alpha-3 isoform X1 [KO:K06240]
126929064  laminin subunit alpha-5 [KO:K06240]
126953585  laminin subunit alpha-4 isoform X1 [KO:K06241]
126951221  laminin subunit beta-1 [KO:K05636]
126948619  laminin subunit beta-2 [KO:K06243]
126949026  laminin subunit beta-3 [KO:K06244]
126951219  laminin subunit beta-4 isoform X1 [KO:K06245]
126950143  laminin subunit gamma-1 isoform X1 [KO:K05635]
126940264  laminin subunit gamma-2 [KO:K06246]
126936881  laminin subunit gamma-3 [KO:K06247]
126939616  chondroadherin [KO:K06248]
126949834  reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
126957930  thrombospondin-1 [KO:K16857]
126933159  thrombospondin-3 isoform X1 [KO:K04659]
126957575  thrombospondin-4 isoform X1 [KO:K04659]
126952464  thrombospondin-2 [KO:K04659]
126942208  cartilage oligomeric matrix protein [KO:K04659]
126932417  fibronectin isoform X1 [KO:K05717]
126954703  osteopontin [KO:K06250]
126938724  vitronectin [KO:K06251]
126938007  tenascin isoform X1 [KO:K06252]
126956954  tenascin-N [KO:K06252]
126940803  tenascin-R isoform X1 [KO:K06252]
126953208  LOW QUALITY PROTEIN: tenascin-X-like [KO:K06252]
126930424  von Willebrand factor isoform X1 [KO:K03900]
126954719  bone sialoprotein 2 [KO:K06253]
126956843  integrin alpha-1 [KO:K06480]
126956842  integrin alpha-2 [KO:K06481]
126938666  integrin alpha-IIb [KO:K06476]
126939866  integrin alpha-3 isoform X1 [KO:K06482]
126932061  integrin alpha-4 [KO:K06483]
126931101  integrin alpha-5 [KO:K06484]
126932479  integrin alpha-6 isoform X1 [KO:K06485]
126931100  integrin alpha-7 isoform X1 [KO:K06583]
126962394  LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
126948472  integrin alpha-9 isoform X1 [KO:K06585]
126931423  integrin alpha-10 isoform X1 [KO:K06586]
126958133  LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
126933042  integrin alpha-V isoform X1 [KO:K06487]
126962945  integrin beta-1 isoform X1 [KO:K05719]
126939509  integrin beta-3 [KO:K06493]
126939156  integrin beta-4 isoform X1 [KO:K06525]
126949108  integrin beta-5 [KO:K06588]
126932940  integrin beta-6 isoform X1 [KO:K06589]
126931103  integrin beta-7 isoform X1 [KO:K06590]
126951352  integrin beta-8 [KO:K06591]
126961367  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126957589  proteinase-activated receptor 1 [KO:K03914]
126935320  muscarinic acetylcholine receptor M1 [KO:K04129]
126949684  muscarinic acetylcholine receptor M2 [KO:K04130]
126937741  lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
126935655  lysophosphatidic acid receptor 1-like isoform X1 [KO:K04289]
126942297  lysophosphatidic acid receptor 2 [KO:K04291]
126963632  lysophosphatidic acid receptor 3 [KO:K04294]
126946250  lysophosphatidic acid receptor 4 [KO:K04275]
126930445  lysophosphatidic acid receptor 5 [KO:K08390]
126940444  lysophosphatidic acid receptor 6 [KO:K04273]
126952008  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126950415  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126930448  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126947562  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126959042  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
126958548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126935530  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
126942604  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126955333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126963646  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126951422  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126935723  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126942881  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126943523  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126937751  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126949943  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126942836  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126939573  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126944893  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126949942  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126939894  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126951240  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
126939669  phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
126939670  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
126944637  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
126944712  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
126942954  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
126956450  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
126932625  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
126962526  DNA damage-inducible transcript 4 protein [KO:K08270]
126936889  hamartin isoform X1 [KO:K07206]
126944570  tuberin isoform X1 [KO:K07207]
126951632  GTP-binding protein Rheb [KO:K07208]
126944692  target of rapamycin complex subunit LST8 [KO:K08266]
126952739  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
126939145  regulatory-associated protein of mTOR [KO:K07204]
126961225  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
126954783  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
126956370  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
126932386  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
126947183  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
126939388  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
126935360  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
126931107  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
126941758  eukaryotic translation initiation factor 4B-like [KO:K03258]
126937697  40S ribosomal protein S6 [KO:K02991]
126946738  40S ribosomal protein S6-like [KO:K02991]
126941928  40S ribosomal protein S6-like [KO:K02991]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126942421  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
126963737  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
126936908  LOW QUALITY PROTEIN: serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
126952874  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
126963835  serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
126961505  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126947634  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
126949884  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
126963336  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
126934473  acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
126961792  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
126955999  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
126943032  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
126935784  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
126961827  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
126955498  protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
126963299  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
126956781  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
126946849  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
126947137  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
126959165  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
126948134  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
126936807  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
126958423  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
126952394  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
126959744  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
126935580  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
126948635  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
126955457  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
126958418  heat shock protein HSP 90-alpha [KO:K04079]
126952392  heat shock protein HSP 90-beta [KO:K04079]
126930897  endoplasmin [KO:K09487]
126933482  CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
126943700  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
126941199  PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
126945514  protein p13 MTCP-1 [KO:K16837]
126951570  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
126938407  breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126930517  glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
126943552  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
126964013  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
126958803  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
126932332  glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
126938517  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
126938691  glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
126960612  myc proto-oncogene protein [KO:K04377]
126935963  G1/S-specific cyclin-D1 [KO:K04503]
126952813  cyclin-dependent kinase inhibitor 1 [KO:K06625]
126930782  cyclin-dependent kinase inhibitor 1B [KO:K06624]
126931216  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
126930400  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
126951304  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
126931745  G1/S-specific cyclin-D2 [KO:K10151]
126953804  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
126943618  G1/S-specific cyclin-E1 [KO:K06626]
126960826  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
126953626  forkhead box protein O3 [KO:K09408]
126944978  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
126941397  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126933423  bcl-2-like protein 11 isoform X1 [KO:K16341]
126954352  14-3-3 protein theta [KO:K16197]
126955364  14-3-3 protein theta-like [KO:K16197]
126963854  14-3-3 protein beta/alpha isoform X1 [KO:K16197]
126933791  14-3-3 protein theta isoform X1 [KO:K16197]
126960893  14-3-3 protein zeta/delta [KO:K16197]
126938876  14-3-3 protein epsilon isoform X1 [KO:K06630]
126950246  14-3-3 protein epsilon-like [KO:K06630]
126963946  14-3-3 protein eta isoform X1 [KO:K16198]
126950401  14-3-3 protein gamma [KO:K16198]
126935617  bcl2-associated agonist of cell death [KO:K02158]
126964283  bcl-2-like protein 1 isoform X1 [KO:K04570]
126941201  apoptosis regulator Bcl-2 [KO:K02161]
126929188  LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
126933094  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
126932678  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
126963745  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126942639  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
126938066  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
126951142  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
126934237  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
126935751  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
126950050  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
126953217  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
126932242  induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
126936987  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
126931034  nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126952852  transcriptional activator Myb isoform X1 [KO:K09420]
126931704  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
126939707  cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mthb00010  Glycolysis / Gluconeogenesis
mthb04010  MAPK signaling pathway
mthb04012  ErbB signaling pathway
mthb04062  Chemokine signaling pathway
mthb04064  NF-kappa B signaling pathway
mthb04068  FoxO signaling pathway
mthb04110  Cell cycle
mthb04115  p53 signaling pathway
mthb04150  mTOR signaling pathway
mthb04210  Apoptosis
mthb04370  VEGF signaling pathway
mthb04510  Focal adhesion
mthb04620  Toll-like receptor signaling pathway
mthb04630  JAK-STAT signaling pathway
mthb04662  B cell receptor signaling pathway
mthb04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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