KEGG   PATHWAY: oas04666
Entry
oas04666                    Pathway                                
Name
Fc gamma R-mediated phagocytosis - Ovis aries (sheep)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
oas04666  Fc gamma R-mediated phagocytosis
oas04666

Other DBs
GO: 0006909
Organism
Ovis aries (sheep) [GN:oas]
Gene
101113211  Ig mu chain C region membrane-bound form [KO:K06856]
100192431  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
101106730  low affinity immunoglobulin gamma Fc region receptor II-like isoform X3 [KO:K06472]
100192433  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A precursor [KO:K06463]
101102917  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
101113167  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
100302103  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
101105303  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101109759  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101110015  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101117348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101123247  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101111546  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101121455  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101118462  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101119242  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100294652  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101107371  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101109574  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101103341  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101122126  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101107639  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101110314  PRKCE; protein kinase C epsilon type isoform X2 [KO:K18050] [EC:2.7.11.13]
101103190  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101123635  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101111472  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101115372  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101115878  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
101116150  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
101116403  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
101103799  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101106083  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
101105729  MARCKSL1; MARCKS-related protein [KO:K13536]
101110687  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
101114661  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101102020  PLPP3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
101106938  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
101115312  PLPP1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
101105263  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
101106964  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
101110074  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101118410  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101116423  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
780489  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
100579169  GSN; gelsolin [KO:K05768]
101123369  SCIN; scinderin [KO:K05768]
101120709  VAV3; guanine nucleotide exchange factor VAV3 isoform X5 [KO:K05730]
101110137  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101107354  VAV1; proto-oncogene vav [KO:K05730]
101102792  CDC42; cell division control protein 42 homolog [KO:K04393]
114108599  cell division control protein 42 homolog [KO:K04393]
101114336  WAS; actin nucleation-promoting factor WAS [KO:K05747]
101113616  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101112965  ACTR2; actin-related protein 2 [KO:K17260]
101108990  ACTR3; actin-related protein 3 [KO:K18584]
101105653  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101113818  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101113558  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X2 [KO:K05757]
101105166  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
101110485  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101105028  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X2 [KO:K05756]
105601868  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
101106701  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100037671  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100101233  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101107592  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
101112488  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
101107336  WASF2; actin-binding protein WASF2 [KO:K05748]
101120599  LOW QUALITY PROTEIN: actin-binding protein WASF2-like [KO:K05748]
101114880  WASF3; actin-binding protein WASF3 isoform X2 [KO:K06083]
101111756  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101110900  LIMK1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
101114815  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
494432  CFL1; cofilin-1 [KO:K05765]
101118388  CFL2; cofilin-2 [KO:K05765]
101114069  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7 [KO:K00889] [EC:2.7.1.68]
101107667  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
101115537  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X7 [KO:K00889] [EC:2.7.1.68]
100302306  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101115380  CRK; adapter molecule crk isoform X1 [KO:K04438]
101117537  CRKL; crk-like protein [KO:K04438]
101117205  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
101122198  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6 [KO:K12488]
101120897  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
101102555  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
100192432  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b precursor [KO:K12560]
101112941  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
101121707  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
101115743  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
101110725  LAT; linker for activation of T-cells family member 1 isoform X3 [KO:K07362]
101115027  DNM2; dynamin-2 isoform X5 [KO:K23484] [EC:3.6.5.5]
101119119  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
101122270  AMPH; amphiphysin isoform X1 [KO:K12562]
101102178  MYO10; unconventional myosin-X isoform X2 [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
oas04020  Calcium signaling pathway
oas04142  Lysosome
oas04144  Endocytosis
oas04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
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