KEGG   PATHWAY: omc04115
Entry
omc04115                    Pathway                                
Name
p53 signaling pathway - Onychostoma macrolepis
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
omc04115  p53 signaling pathway
omc04115

Organism
Onychostoma macrolepis [GN:omc]
Gene
131520335  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
131520898  sesn3; sestrin-3 [KO:K10141]
131520988  ppm1da; protein phosphatase, Mg2+/Mn2+ dependent, 1Da [KO:K10147] [EC:3.1.3.16]
131521209  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
131521806  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
131522268  adgrb1a; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
131523039  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
131523082  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
131523180  siva1; apoptosis regulatory protein Siva [KO:K22744]
131523186  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131523347  thbs1a; thrombospondin-1 [KO:K16857]
131523993  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
131524203  ppp1r13l; relA-associated inhibitor isoform X1 [KO:K27356]
131524311  bida; BH3 interacting domain death agonist [KO:K04726]
131524382  [KO:K05868]
131524512  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
131524729  cd82b; CD82 molecule b [KO:K06509]
131524820  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
131524878  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
131525323  sesn2; sestrin-2 [KO:K20394]
131525516  [KO:K06626]
131525744  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
131526064  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
131526424  [KO:K04596]
131526559  gorab; RAB6-interacting golgin [KO:K19748]
131527248  thbs1b; thrombospondin-1 [KO:K16857]
131527298  sesn1; sestrin-1 isoform X1 [KO:K10141]
131527633  [KO:K10808] [EC:1.17.4.1]
131527755  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
131528161  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
131528468  ccng2; cyclin-G2 [KO:K10146]
131529355  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
131529448  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
131529620  cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
131529954  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
131530521  [KO:K10135]
131531003  [KO:K10135]
131531547  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
131531774  bcl2l1; bcl-2-like protein 1 [KO:K04570]
131531782  znf385a; zinc finger protein 385A isoform X1 [KO:K26543]
131531881  rprm3; reprimo, TP53 dependent G2 arrest mediator homolog 3 [KO:K10128]
131532003  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
131533091  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
131534119  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
131534247  pidd1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
131536189  [KO:K02159]
131536309  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
131537993  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
131538564  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
131539000  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
131539081  ccnd2b; LOW QUALITY PROTEIN: G1/S-specific cyclin-D2b [KO:K10151]
131539332  igf1; insulin-like growth factor I [KO:K05459]
131539470  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
131540050  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
131540531  casp22; caspase-22 isoform X1 [KO:K04398] [EC:3.4.22.61]
131540649  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
131540908  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
131541038  tsc2; tuberin isoform X1 [KO:K07207]
131541085  rchy1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
131541252  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
131541605  ppm1db; protein phosphatase, Mg2+/Mn2+ dependent, 1Db [KO:K10147] [EC:3.1.3.16]
131541801  [KO:K08738]
131542074  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
131542287  casp20; caspase 20, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
131542291  rprmb; protein reprimo B [KO:K10128]
131542296  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
131543330  [KO:K04451]
131543753  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
131544085  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
131544284  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
131544494  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
131544625  zgc:153993; apoptosis regulator BAX [KO:K02159]
131544956  cd82a; CD82 molecule a [KO:K06509]
131545749  tp73; LOW QUALITY PROTEIN: tumor protein p73 [KO:K10148]
131545764  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
131546950  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
131547061  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
131547264  rprma; LOW QUALITY PROTEIN: protein reprimo A [KO:K10128]
131548465  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
131548719  pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
131549214  mdm4; protein Mdm4 isoform X1 [KO:K10127]
131549328  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
131549350  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
131549489  cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
131549575  zmat3; LOW QUALITY PROTEIN: zinc finger matrin-type protein 3 [KO:K10137]
131550661  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131552268  aifm2; apoptosis-inducing factor 2 [KO:K22745]
131552511  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
131552912  casp3b; caspase-3b isoform X1 [KO:K02187] [EC:3.4.22.56]
131553543  ccng1; cyclin-G1 [KO:K10145]
131553705  sesn4; sestrin-3 [KO:K10141]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
omc04110  Cell cycle
omc04210  Apoptosis
omc04218  Cellular senescence
KO pathway
ko04115   

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