KEGG   PATHWAY: onl00280
Entry
onl00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Oreochromis niloticus (Nile tilapia)
Class
Metabolism; Amino acid metabolism
Pathway map
onl00280  Valine, leucine and isoleucine degradation
onl00280

Module
onl_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:onl00280]
onl_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:onl00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100689799  pcca; propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2 [KO:K01965] [EC:6.4.1.3]
100689827  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
100690782  hibch; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [KO:K05605] [EC:3.1.2.4]
100691111  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
100691671  [KO:K00020] [EC:1.1.1.31]
100691740  dbt; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
100692418  acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09478] [EC:1.3.8.5]
100692528  mcee; methylmalonyl-CoA epimerase, mitochondrial isoform X2 [KO:K05606] [EC:5.1.99.1]
100692833  aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
100693621  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
100693722  bckdhb; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [KO:K00167] [EC:1.2.4.4]
100693723  [KO:K00128] [EC:1.2.1.3]
100694545  mccc2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
100695605  [KO:K03334] [EC:1.4.3.2]
100696213  acad8; LOW QUALITY PROTEIN: isobutyryl-CoA dehydrogenase, mitochondrial [KO:K11538] [EC:1.3.99.-]
100696541  [KO:K00020] [EC:1.1.1.31]
100697026  [KO:K01969] [EC:6.4.1.4]
100697128  hmgcll1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
100697201  [KO:K03334] [EC:1.4.3.2]
100697484  [KO:K05607] [EC:4.2.1.18]
100698450  abat; 4-aminobutyrate aminotransferase, mitochondrial isoform X2 [KO:K13524] [EC:2.6.1.19 2.6.1.22]
100698670  [KO:K00128] [EC:1.2.1.3]
100698741  pccb; propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
100699093  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100699406  acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
100699540  acads; short-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00248] [EC:1.3.8.1]
100700973  [KO:K05607] [EC:4.2.1.18]
100701752  [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100702026  [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100702383  ivd; isovaleryl-CoA dehydrogenase, mitochondrial [KO:K00253] [EC:1.3.8.4]
100702912  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
100703044  [KO:K03334] [EC:1.4.3.2]
100703315  [KO:K03334] [EC:1.4.3.2]
100703423  [KO:K07515] [EC:4.2.1.17 1.1.1.211]
100703463  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100704158  [KO:K07515] [EC:4.2.1.17 1.1.1.211]
100704813  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
100705559  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
100705854  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
100706017  oxct1; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [KO:K01027] [EC:2.8.3.5]
100706080  bckdha; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [KO:K00166] [EC:1.2.4.4]
100706096  [KO:K00140] [EC:1.2.1.18 1.2.1.27]
100707145  mccc1; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial isoform X1 [KO:K01968] [EC:6.4.1.4]
100707184  aldh2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
100707441  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100707807  [KO:K00826] [EC:2.6.1.42]
100707810  acsf3; acyl-CoA synthetase family member 3, mitochondrial isoform X1 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
100707943  [KO:K03334] [EC:1.4.3.2]
100708434  aox6; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
100708775  mut; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
100708820  aldh6a1; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
100708936  hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100709434  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
100709781  hadhb; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
100709821  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
100710578  hmgcl; hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
100711018  [KO:K00826] [EC:2.6.1.42]
100712075  [KO:K01641] [EC:2.3.3.10]
102078228  [KO:K05607] [EC:4.2.1.18]
102078289  [KO:K00128] [EC:1.2.1.3]
102082725  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109194280  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109196929  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
onl00020  Citrate cycle (TCA cycle)
onl00240  Pyrimidine metabolism
onl00290  Valine, leucine and isoleucine biosynthesis
onl00640  Propanoate metabolism
onl00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

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