KEGG   PATHWAY: panu04750
Entry
panu04750                   Pathway                                
Name
Inflammatory mediator regulation of TRP channels - Papio anubis (olive baboon)
Description
The TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive dorsal root ganglion (DRG) neuron cell bodies including their peripheral and central projections. These channels can be modulated indirectly by inflammatory mediators such as PGE2, bradykinin, ATP, NGF, and proinflammatory cytokines that are generated during tissue injury. While the noxious heat receptor TRPV1 is sensitized (that is, their excitability can be increased) by post-translational modifications upon activation of G-protein coupled receptors (GPCRs) or tyrosine kinase receptors, the receptors for inflammatory mediators, the same action appears to mainly desensitize TRPM8, the main somatic innocuous cold sensor. This aforementioned sensitization could allow the receptor to become active at body temperature, so it not only contributes toward thermal hypersensitivity but also is possibly a substrate for ongoing persistent pain.
Class
Organismal Systems; Sensory system
Pathway map
panu04750  Inflammatory mediator regulation of TRP channels
panu04750

Other DBs
GO: 0019233
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100137333  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100137386  TRPM8; transient receptor potential cation channel subfamily M member 8 [KO:K04983]
100137608  ASIC4; acid-sensing ion channel 4 [KO:K04831]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
100997036  CALM2; calmodulin-2 [KO:K02183]
100997114  PRKCH; protein kinase C eta type isoform X2 [KO:K18051] [EC:2.7.11.13]
100997835  CALML5; calmodulin-like protein 5 [KO:K02183]
100998237  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100998449  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100998471  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
100998530  CALML3; calmodulin-like protein 3 [KO:K02183]
100998582  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X3 [KO:K04971]
100998763  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100999120  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
100999243  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
100999996  TRPV3; transient receptor potential cation channel subfamily V member 3 [KO:K04972]
101000142  [KO:K16342] [EC:3.1.1.4]
101000833  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101001103  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101001272  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101001515  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X4 [KO:K04433] [EC:2.7.12.2]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101002393  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101002468  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101002819  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101003536  ASIC1; acid-sensing ion channel 1 isoform X3 [KO:K04829]
101003909  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101003920  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101004091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101004198  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
101004325  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101004867  TRPV1; transient receptor potential cation channel subfamily V member 1 [KO:K05222]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101005868  PRKCQ; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
101006152  ASIC2; acid-sensing ion channel 2 isoform X1 [KO:K04828]
101006469  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101006754  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101006785  [KO:K04632]
101007101  CALM1; calmodulin-1 isoform X1 [KO:K02183]
101007115  ADCY8; adenylate cyclase type 8 isoform X3 [KO:K08048] [EC:4.6.1.1]
101007440  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008785  ADCY6; adenylate cyclase type 6 isoform X3 [KO:K08046] [EC:4.6.1.1]
101008925  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10 [KO:K04515] [EC:2.7.11.17]
101009708  P2RY2; P2Y purinoceptor 2 [KO:K04269]
101009865  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101009984  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X37 [KO:K04515] [EC:2.7.11.17]
101010000  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
101010276  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101011087  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101011767  CALM3; calmodulin-3 isoform X2 [KO:K02183]
101011888  F2RL1; proteinase-activated receptor 2 [KO:K04234]
101012078  KNG1; kininogen-1 isoform X2 [KO:K03898]
101012165  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101012275  [KO:K07413] [EC:1.14.14.1]
101012580  [KO:K00458] [EC:1.13.11.31]
101012583  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
101012772  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101012903  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101012932  ALOX12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
101013075  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
101013424  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101013950  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
101014300  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X2 [KO:K04259]
101014305  BDKRB2; B2 bradykinin receptor [KO:K03916]
101014342  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101014828  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101014902  BDKRB1; B1 bradykinin receptor [KO:K03915]
101015175  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101015622  TRPV4; transient receptor potential cation channel subfamily V member 4 isoform X2 [KO:K04973]
101016118  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
101016452  TRPA1; transient receptor potential cation channel subfamily A member 1 isoform X1 [KO:K04984]
101016532  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
101017317  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101017420  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
101017532  CALML6; calmodulin-like protein 6 [KO:K02183]
101019572  HRH1; histamine H1 receptor [KO:K04149]
101019754  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019885  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18 [KO:K04515] [EC:2.7.11.17]
101020553  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101021139  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101022026  PRKCE; protein kinase C epsilon type isoform X2 [KO:K18050] [EC:2.7.11.13]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101022804  ASIC5; acid-sensing ion channel 5 [KO:K04832]
101023200  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101023446  IL1B; interleukin-1 beta [KO:K04519]
101024177  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101024189  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101024771  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101025530  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101025668  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101026117  [KO:K07413] [EC:1.14.14.1]
101026142  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101026251  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X15 [KO:K04345] [EC:2.7.11.11]
101026282  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101026648  ASIC3; acid-sensing ion channel 3 isoform X1 [KO:K04830]
103887915  [KO:K04632]
116269450  [KO:K04515] [EC:2.7.11.17]
116269451  [KO:K04515] [EC:2.7.11.17]
116272421  [KO:K04971]
116276324  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116276330  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
Compound
C00002  ATP
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00219  Arachidonate
C00388  Histamine
C00400  (-)-Menthol
C00469  Ethanol
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00780  Serotonin
C00808  (+)-Camphor
C00809  (-)-Camphor
C00903  Cinnamaldehyde
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04805  5(S)-HETE
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06254  Lysophospholipid
C06866  Capsaicin
C07600  Allicin
C09155  Phorbol
C09179  Resiniferatoxin
C09844  1,8-Cineole
C11695  Anandamide
C12083  (5Z,7E,9E,14Z,17Z)-Icosapentaenoate
C12271  N-Arachidonyldopamine
C14768  5,6-EET
C14769  8,9-EET
C19317  Allyl isothiocyanate
C20171  Icilin
C20698  2-Aminoethyl diphenylborinate
Reference
PMID:15820689
  Authors
Wang H, Woolf CJ
  Title
Pain TRPs.
  Journal
Neuron 46:9-12 (2005)
DOI:10.1016/j.neuron.2005.03.011
Reference
PMID:17321113
  Authors
Levine JD, Alessandri-Haber N
  Title
TRP channels: targets for the relief of pain.
  Journal
Biochim Biophys Acta 1772:989-1003 (2007)
DOI:10.1016/j.bbadis.2007.01.008
Reference
PMID:18427980
  Authors
Cheng JK, Ji RR
  Title
Intracellular signaling in primary sensory neurons and persistent pain.
  Journal
Neurochem Res 33:1970-8 (2008)
DOI:10.1007/s11064-008-9711-z
Reference
PMID:24099085
  Authors
Julius D
  Title
TRP channels and pain.
  Journal
Annu Rev Cell Dev Biol 29:355-84 (2013)
DOI:10.1146/annurev-cellbio-101011-155833
Reference
PMID:12838328
  Authors
Patapoutian A, Peier AM, Story GM, Viswanath V
  Title
ThermoTRP channels and beyond: mechanisms of temperature sensation.
  Journal
Nat Rev Neurosci 4:529-39 (2003)
DOI:10.1038/nrn1141
Reference
PMID:16776582
  Authors
Dhaka A, Viswanath V, Patapoutian A
  Title
Trp ion channels and temperature sensation.
  Journal
Annu Rev Neurosci 29:135-61 (2006)
DOI:10.1146/annurev.neuro.29.051605.112958
Reference
PMID:18615141
  Authors
Story GM
  Title
The emerging role of TRP channels in mechanisms of temperature and pain sensation.
  Journal
Curr Neuropharmacol 4:183-96 (2006)
DOI:10.2174/157015906778019482
Reference
PMID:17548207
  Authors
Velazquez KT, Mohammad H, Sweitzer SM
  Title
Protein kinase C in pain: involvement of multiple isoforms.
  Journal
Pharmacol Res 55:578-89 (2007)
DOI:10.1016/j.phrs.2007.04.006
Reference
PMID:16319926
  Authors
Zhang X, Huang J, McNaughton PA
  Title
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.
  Journal
EMBO J 24:4211-23 (2005)
DOI:10.1038/sj.emboj.7600893
Reference
PMID:19074743
  Authors
Bessac BF, Jordt SE
  Title
Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.
  Journal
Physiology (Bethesda) 23:360-70 (2008)
DOI:10.1152/physiol.00026.2008
Reference
PMID:17684094
  Authors
Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P
  Title
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
  Journal
Proc Natl Acad Sci U S A 104:13519-24 (2007)
DOI:10.1073/pnas.0705923104
Reference
PMID:21841075
  Authors
Latorre R, Brauchi S, Madrid R, Orio P
  Title
A cool channel in cold transduction.
  Journal
Physiology (Bethesda) 26:273-85 (2011)
DOI:10.1152/physiol.00004.2011
Reference
PMID:20932256
  Authors
Babes A, Ciobanu AC, Neacsu C, Babes RM
  Title
TRPM8, a sensor for mild cooling in mammalian sensory nerve endings.
  Journal
Curr Pharm Biotechnol 12:78-88 (2011)
DOI:10.2174/138920111793937835
Reference
PMID:23000387
  Authors
Loyd DR, Henry MA, Hargreaves KM
  Title
Serotonergic neuromodulation of peripheral nociceptors.
  Journal
Semin Cell Dev Biol 24:51-7 (2013)
DOI:10.1016/j.semcdb.2012.09.002
Reference
PMID:17124270
  Authors
Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW
  Title
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
  Journal
J Physiol 578:715-33 (2007)
DOI:10.1113/jphysiol.2006.121111
Reference
PMID:22470230
  Authors
Mandadi S, Armati PJ, Roufogalis BD
  Title
Protein kinase C modulation of thermo-sensitive transient receptor potential channels: Implications for pain signaling.
  Journal
J Nat Sci Biol Med 2:13-25 (2011)
DOI:10.4103/0976-9668.82311
Related
pathway
panu00590  Arachidonic acid metabolism
panu04010  MAPK signaling pathway
panu04020  Calcium signaling pathway
KO pathway
ko04750   

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