KEGG   PATHWAY: aful00230
Entry
aful00230                   Pathway                                
Name
Purine metabolism - Aythya fuligula (tufted duck)
Class
Metabolism; Nucleotide metabolism
Pathway map
aful00230  Purine metabolism
aful00230

Module
aful_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:aful00230]
aful_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:aful00230]
aful_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:aful00230]
aful_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:aful00230]
aful_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:aful00230]
aful_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:aful00230]
Other DBs
GO: 0006163 0042278
Organism
Aythya fuligula (tufted duck) [GN:aful]
Gene
116488725  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
116496663  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
116491303  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
116492112  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
116488876  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
116497215  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
116494366  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
116488854  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
116491147  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
116492550  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
116490881  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
116493901  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
116498047  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
116487998  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
116489910  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
116499317  cytosolic purine 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
116495387  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
116491292  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
116487218  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
116494063  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
116498785  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
116494089  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
116494303  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
116493193  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
116502256  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
116487366  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
116495147  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
116495148  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
116496389  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
116496390  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
116487468  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
116491223  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
116486172  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
116496933  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
116497037  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
116497038  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
116496521  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
116499462  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
116487878  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
116489667  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
116492022  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
116487376  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116500658  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
116492386  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
116486126  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
116501180  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
116485996  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
116494370  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
116487652  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
116486089  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
116488353  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
116499482  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
116489205  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
116494703  deoxycytidine kinase-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
116499661  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
116486732  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116488201  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116490539  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116499930  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
116494191  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
116486321  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116495186  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
116500764  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
116500997  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
116500999  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
116501003  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
116488968  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
116499568  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
116492460  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
116488482  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
116499811  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
116502019  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
116499522  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
116500975  LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
116501143  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
116485578  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
116490997  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
116501553  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
116492506  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
116489860  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
116489106  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
116500698  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
116491534  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
116492632  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
116496650  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
116501279  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
116501399  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
116487585  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
116490716  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
116487701  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
116490181  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
116498925  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
116498934  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
116489715  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
116491152  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
116495764  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
116494290  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
116492075  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
116492194  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
116498161  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
116489477  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
116496867  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
116496868  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
116500682  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
116500592  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
116496795  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
116488146  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
116487488  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116488133  ENPP3; LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116491974  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
116499203  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
116500409  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
116487767  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
116485824  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
116493441  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
116500761  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
116493262  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
116488297  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
116488492  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116491189  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116491890  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
aful00030  Pentose phosphate pathway
aful00220  Arginine biosynthesis
aful00250  Alanine, aspartate and glutamate metabolism
aful00260  Glycine, serine and threonine metabolism
aful00340  Histidine metabolism
aful00630  Glyoxylate and dicarboxylate metabolism
aful00730  Thiamine metabolism
aful00740  Riboflavin metabolism
aful00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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