KEGG   PATHWAY: aju04152
Entry
aju04152                    Pathway                                
Name
AMPK signaling pathway - Acinonyx jubatus (cheetah)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
aju04152  AMPK signaling pathway
aju04152

Other DBs
GO: 2000479
Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106983077  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
106983714  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
106972307  calcium-binding protein 39 [KO:K08272]
106972688  calcium-binding protein 39-like [KO:K08272]
106978688  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
106978266  STE20-related kinase adapter protein beta [KO:K17532]
106988453  leptin isoform X1 [KO:K05424]
106980341  leptin receptor isoform X1 [KO:K05062]
106967543  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
106966540  alpha-1A adrenergic receptor isoform X2 [KO:K04135]
106968005  adiponectin isoform X1 [KO:K07296]
106972550  adiponectin receptor protein 1 [KO:K07297]
106965409  adiponectin receptor protein 2 [KO:K07297]
106970910  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
106974988  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
106985832  5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
106971697  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
106969288  5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
106970101  5'-AMP-activated protein kinase subunit gamma-3 isoform X3 [KO:K07200]
106969553  5'-AMP-activated protein kinase subunit gamma-2 isoform X10 [KO:K07200]
106986459  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X6 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
106981793  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X2 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
106982334  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X2 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
106979216  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X7 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
106971478  fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
106971479  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
106969302  ATP-dependent 6-phosphofructokinase, muscle type isoform X2 [KO:K00850] [EC:2.7.1.11]
106985660  ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
106977731  ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
106968950  hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
106972623  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
106970303  glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
106974277  glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
106988891  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
106979460  phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
113598108  CREB-regulated transcription coactivator 2 [KO:K16333]
106967098  cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
106981255  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
106970423  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
106987262  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
106975473  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
106978069  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
106987665  cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047]
106986838  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2 [KO:K07202]
106970816  ELAV-like protein 1 [KO:K13088]
106971167  G1/S-specific cyclin-D1 [KO:K04503]
106977098  cyclin-A2 [KO:K06627]
106973846  cyclin-A1 isoform X1 [KO:K06627]
106970506  eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
106982155  elongation factor 2 [KO:K03234]
106972644  forkhead box protein O1 [KO:K07201]
106986643  forkhead box protein O3 isoform X1 [KO:K09408]
106967135  NAD-dependent protein deacetylase sirtuin-1 isoform X4 [KO:K11411] [EC:2.3.1.286]
106972419  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
106967981  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
106988702  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
106987707  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
106974837  3-hydroxy-3-methylglutaryl-Coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
106981387  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
106986313  fatty acid synthase [KO:K00665] [EC:2.3.1.85]
106980419  acetyl-CoA carboxylase 1 isoform X7 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106966865  stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
106971276  stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
106979653  acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106985619  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
106971087  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
106987645  carnitine O-palmitoyltransferase 1, muscle isoform isoform X2 [KO:K19523] [EC:2.3.1.21]
106983111  carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
106981471  cell death activator CIDE-A isoform X1 [KO:K25893]
106966583  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
106984892  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
106984444  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
106973000  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
106966536  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
106985785  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
106984955  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
106982733  protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
106987475  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X4 [KO:K11583]
106982041  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
106987100  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
106966766  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
106975965  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
106971318  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
106974042  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
106971234  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2 [KO:K11584]
106979166  TBC1 domain family member 1 isoform X1 [KO:K18341]
106973803  ras-related protein Rab-2A isoform X1 [KO:K07877]
106985924  ras-related protein Rab-8A [KO:K07901]
106967827  ras-related protein Rab-10 [KO:K07903]
106970775  ras-related protein Rab-11B [KO:K07905]
106986618  ras-related protein Rab-14 [KO:K07881]
106970664  cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
106982490  platelet glycoprotein 4 [KO:K06259]
106971906  insulin-like growth factor I isoform X4 [KO:K05459]
106975144  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
113595531  insulin [KO:K04526]
106979040  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
106972296  insulin receptor substrate 1 [KO:K16172]
113601123  insulin receptor substrate 2 [KO:K07187]
106987435  insulin receptor substrate 1-like isoform X2 [KO:K17445]
106973150  insulin receptor substrate 4 [KO:K17446]
106984896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106984265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106973880  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106976917  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106973297  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106969150  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106978772  3-phosphoinositide-dependent protein kinase 1 isoform X5 [KO:K06276] [EC:2.7.11.1]
106979622  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106975558  RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
106985046  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106982748  tuberin isoform X2 [KO:K07207]
106985348  hamartin isoform X1 [KO:K07206]
106969555  GTP-binding protein Rheb [KO:K07208]
106984907  serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
106981870  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
106983118  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
106972702  ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
106971103  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
106978406  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
106977134  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
106979514  serine/threonine-protein kinase ULK1 isoform X2 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
aju00010  Glycolysis / Gluconeogenesis
aju00061  Fatty acid biosynthesis
aju00500  Starch and sucrose metabolism
aju01040  Biosynthesis of unsaturated fatty acids
aju04110  Cell cycle
aju04140  Autophagy - animal
aju04150  mTOR signaling pathway
aju04151  PI3K-Akt signaling pathway
aju04910  Insulin signaling pathway
aju04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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