KEGG   PATHWAY: aju04140
Entry
aju04140                    Pathway                                
Name
Autophagy - animal - Acinonyx jubatus (cheetah)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
aju04140  Autophagy - animal
aju04140

Other DBs
GO: 0006914
Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
113595531  insulin [KO:K04526]
106975144  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
106972296  insulin receptor substrate 1 [KO:K16172]
113601123  insulin receptor substrate 2 [KO:K07187]
106987435  insulin receptor substrate 1-like isoform X2 [KO:K17445]
106973150  insulin receptor substrate 4 [KO:K17446]
106984896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106984265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106973880  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106976917  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106973297  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106969150  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106978772  3-phosphoinositide-dependent protein kinase 1 isoform X5 [KO:K06276] [EC:2.7.11.1]
106979622  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106975558  RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
106985046  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106980972  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X4 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106987957  GTPase HRas isoform X1 [KO:K02833]
106968778  GTPase KRas isoform X1 [KO:K07827]
106969596  GTPase NRas [KO:K07828]
106976712  ras-related protein M-Ras isoform X2 [KO:K07831]
106983109  ras-related protein R-Ras isoform X1 [KO:K07829]
106971853  ras-related protein R-Ras2 isoform X2 [KO:K07830]
106977129  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106980282  dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
106975474  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106969232  mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
106990008  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106971299  hypoxia-inducible factor 1-alpha [KO:K08268]
106967205  DNA damage-inducible transcript 4 protein [KO:K08270]
106982748  tuberin isoform X2 [KO:K07207]
106985348  hamartin isoform X1 [KO:K07206]
106985778  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
106969555  GTP-binding protein Rheb [KO:K07208]
106981870  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
106987378  DEP domain-containing mTOR-interacting protein [KO:K20402]
106984907  serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
106983118  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
106978709  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
106972702  ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
106971103  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
106971469  LOW QUALITY PROTEIN: immunoglobulin-binding protein 1-like [KO:K17606]
106982397  immunoglobulin-binding protein 1 [KO:K17606]
106966583  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
106984892  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
106979514  serine/threonine-protein kinase ULK1 isoform X2 [KO:K21357] [EC:2.7.11.1]
106981411  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
106978034  autophagy-related protein 13 isoform X1 [KO:K08331]
106986456  autophagy-related protein 101 [KO:K19730]
106974082  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
106972195  autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
106971157  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
106984491  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
106975308  WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
106989018  WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [KO:K22991]
113596981  WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
106970097  autophagy-related protein 9A isoform X1 [KO:K17907]
106969576  autophagy-related protein 9B isoform X1 [KO:K17907]
106979583  transcription factor SPT20 homolog [KO:K21245]
106973839  transcription factor SPT20 homolog isoform X1 [KO:K21245]
113597740  transcription factor SPT20 homolog [KO:K21245]
106989771  transcription factor SPT20 homolog [KO:K21245]
106981397  guanine nucleotide exchange protein SMCR8 [KO:K23611]
106974822  WD repeat-containing protein 41 isoform X4 [KO:K23610]
106977831  C9orf72; guanine nucleotide exchange factor C9orf72 homolog [KO:K23609]
106985924  ras-related protein Rab-8A [KO:K07901]
106984423  ras-related protein Rab-39B [KO:K07925]
106969863  sequestosome-1 [KO:K14381]
106981360  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
106984620  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
106976239  ras-related protein Rab-1A [KO:K07874]
106985283  ras-related GTP-binding protein B isoform X1 [KO:K16185]
106969767  ras-related GTP-binding protein A [KO:K16185]
106972548  ras-related GTP-binding protein D [KO:K16186]
106973269  ras-related GTP-binding protein C [KO:K16186]
106983714  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
106970910  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
106974988  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
106973352  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106985791  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106987049  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
106969894  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106970668  mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
106989581  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106985187  apoptosis regulator Bcl-2 [KO:K02161]
106986010  bcl-2-like protein 1 [KO:K04570]
106981699  bcl2-associated agonist of cell death [KO:K02158]
106972618  beclin-1 isoform X1 [KO:K08334]
106975548  beclin-2 [KO:K08334]
106989876  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
106971603  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
106972936  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
106984342  beclin 1-associated autophagy-related key regulator [KO:K17889]
106978066  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
106976941  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106974017  tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
106972700  vacuole membrane protein 1 isoform X1 [KO:K21248]
106972061  syntaxin-17 [KO:K08491]
106976447  UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
106973330  endophilin-B1 isoform X2 [KO:K11248]
106983367  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
106967543  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
106983077  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
106978670  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106978946  inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
106987289  death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
106971447  death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
113596415  death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
113593044  LOW QUALITY PROTEIN: high mobility group protein B1-like [KO:K10802]
106985545  high mobility group protein B1 [KO:K10802]
106987510  proline-rich acidic protein 1 [KO:K21250]
106978143  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
106968549  eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
106971552  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106989945  myotubularin-related protein 4 isoform X2 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
106985452  myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
106972336  myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
106974450  zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
106978931  ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
106978885  autophagy protein 5 isoform X1 [KO:K08339]
106975898  autophagy-related protein 16-1 isoform X1 [KO:K17890]
106970930  protein Atg16l2 isoform X1 [KO:K20868]
106977116  ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
106967950  ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
106972282  ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
106987988  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
106976196  ras-related protein Rab-33B [KO:K07920]
106982347  protein kinase C theta type isoform X2 [KO:K18052] [EC:2.7.11.13]
106965636  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
106983422  gamma-aminobutyric acid receptor-associated protein-like 2 isoform X2 [KO:K08341]
106972484  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
106972090  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
106973543  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
106975556  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
106975561  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
113602522  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
106967335  cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
106980786  cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
106984607  cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
106980307  cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
106972580  next to BRCA1 gene 1 protein [KO:K17987]
106971030  optineurin isoform X1 [KO:K19946]
106980533  calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
106987664  tax1-binding protein 1 isoform X1 [KO:K21347]
106981373  WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
128311958  LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40-like [KO:K02927]
106969077  ubiquitin-60S ribosomal protein L40 [KO:K02927]
106976779  ubiquitin-40S ribosomal protein S27a [KO:K02977]
106973238  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
106978339  polyubiquitin-C [KO:K08770]
106990003  synaptosomal-associated protein 29 [KO:K08509]
106978205  vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
106968205  synaptobrevin homolog YKT6 isoform X1 [KO:K08516]
106976875  syntaxin-7 isoform X1 [KO:K08488]
106972960  ectopic P granules protein 5 homolog [KO:K23883]
106988154  pleckstrin homology domain-containing family M member 1 [KO:K23282]
106983903  vacuolar protein sorting-associated protein 11 homolog isoform X3 [KO:K20179]
106980140  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
106968528  vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
106967559  vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
106968511  vam6/Vps39-like protein [KO:K20183]
106974410  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
106967931  baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
106987793  Golgi reassembly-stacking protein 2 [KO:K26797]
106966654  Golgi reassembly-stacking protein 1 isoform X3 [KO:K26797]
106985293  LOW QUALITY PROTEIN: ras-related protein Rab-7a-like [KO:K07897]
106977704  ras-related protein Rab-7a [KO:K07897]
106972921  ras-related protein Rab-7b isoform X1 [KO:K07898]
106986702  lysosome-associated membrane glycoprotein 1 [KO:K06528]
106986117  lysosome-associated membrane glycoprotein 2 isoform X2 [KO:K06528]
106971074  cathepsin D [KO:K01379] [EC:3.4.23.5]
106971460  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
106971464  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
106971491  procathepsin L [KO:K01365] [EC:3.4.22.15]
106971473  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
113596115  procathepsin L-like isoform X2 [KO:K01365] [EC:3.4.22.15]
106971463  procathepsin L [KO:K01365] [EC:3.4.22.15]
113596116  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
106971474  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
106971459  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
106975817  cathepsin B isoform X3 [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
aju04010  MAPK signaling pathway
aju04141  Protein processing in endoplasmic reticulum
aju04142  Lysosome
aju04150  mTOR signaling pathway
aju04152  AMPK signaling pathway
aju04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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