KEGG   PATHWAY: aju04150
Entry
aju04150                    Pathway                                
Name
mTOR signaling pathway - Acinonyx jubatus (cheetah)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
aju04150  mTOR signaling pathway
aju04150

Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106973510  large neutral amino acids transporter small subunit 1 [KO:K13780]
106981745  4F2 cell-surface antigen heavy chain [KO:K06519]
106975250  sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
106977759  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
106967713  V-type proton ATPase subunit B, kidney isoform [KO:K02147]
106971859  V-type proton ATPase subunit B, brain isoform [KO:K02147]
106989243  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
106980052  V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
106971551  V-type proton ATPase subunit D isoform X1 [KO:K02149]
106965419  V-type proton ATPase subunit E 1 [KO:K02150]
106977229  V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
106976229  V-type proton ATPase subunit F-like [KO:K02151]
106973921  V-type proton ATPase subunit F [KO:K02151]
106978571  V-type proton ATPase subunit G 1 [KO:K02152]
106983969  V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
106974286  V-type proton ATPase subunit G 3 [KO:K02152]
106974079  V-type proton ATPase subunit H isoform X1 [KO:K02144]
106970936  ragulator complex protein LAMTOR1 [KO:K20397]
106981511  ragulator complex protein LAMTOR2 [KO:K20398]
106974541  ragulator complex protein LAMTOR3-like [KO:K04370]
113602725  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR3-like [KO:K04370]
106972162  ragulator complex protein LAMTOR3 [KO:K04370]
106987440  ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
106977961  ragulator complex protein LAMTOR5 [KO:K16344]
106981429  folliculin isoform X1 [KO:K09594]
106970690  folliculin-interacting protein 1 isoform X1 [KO:K20400]
106967454  folliculin-interacting protein 2 isoform X1 [KO:K20401]
106985283  ras-related GTP-binding protein B isoform X1 [KO:K16185]
106969767  ras-related GTP-binding protein A [KO:K16185]
106972548  ras-related GTP-binding protein D [KO:K16186]
106973269  ras-related GTP-binding protein C [KO:K16186]
106977533  sestrin-2 [KO:K20394]
106983320  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
106977505  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
106970016  GATOR complex protein MIOS [KO:K20407]
106989234  nucleoporin SEH1 isoform X1 [KO:K14299]
113594997  GATOR complex protein WDR24 [KO:K20408]
106988719  GATOR complex protein WDR59 isoform X1 [KO:K20409]
106972376  protein SEC13 homolog isoform X1 [KO:K14004]
106983296  GATOR complex protein DEPDC5 isoform X5 [KO:K20404]
106989738  GATOR complex protein NPRL2 [KO:K20405]
106977321  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
106979642  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
106979383  E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
106981870  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
106983118  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
106984907  serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
106987378  DEP domain-containing mTOR-interacting protein [KO:K20402]
106978709  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
106982764  telomere length regulation protein TEL2 homolog isoform X2 [KO:K11137]
106974504  TELO2-interacting protein 1 homolog isoform X2 [KO:K20403]
106967600  CAP-Gly domain-containing linker protein 1 isoform X4 [KO:K10421]
106968216  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
106977267  phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
106986074  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
106974494  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
106979514  serine/threonine-protein kinase ULK1 isoform X2 [KO:K21357] [EC:2.7.11.1]
106981411  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
106978406  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
106967332  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
106975891  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
106975364  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
106972702  ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
106971103  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
106986451  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
113600829  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
106971112  40S ribosomal protein S6 [KO:K02991]
106978688  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
106978266  STE20-related kinase adapter protein beta [KO:K17532]
106983714  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
106972307  calcium-binding protein 39 [KO:K08272]
106972688  calcium-binding protein 39-like [KO:K08272]
106970910  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
106974988  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
106985348  hamartin isoform X1 [KO:K07206]
106982748  tuberin isoform X2 [KO:K07207]
106974184  TBC1 domain family member 7 isoform X1 [KO:K20396]
106969555  GTP-binding protein Rheb [KO:K07208]
106967205  DNA damage-inducible transcript 4 protein [KO:K08270]
106969330  proto-oncogene Wnt-1 [KO:K03209]
106969623  protein Wnt-2b [KO:K00182]
106970665  protein Wnt-2 [KO:K00182]
106985206  protein Wnt-3a [KO:K00312]
106988834  proto-oncogene Wnt-3 isoform X3 [KO:K00312]
113599491  protein Wnt-4 isoform X1 [KO:K00408]
106967018  protein Wnt-5a isoform X1 [KO:K00444]
106965408  protein Wnt-5b isoform X3 [KO:K00444]
106970073  protein Wnt-6 [KO:K00445]
106978815  protein Wnt-7a isoform X1 [KO:K00572]
113602684  protein Wnt-7b isoform X2 [KO:K00572]
106966936  protein Wnt-8b [KO:K00714]
106968544  protein Wnt-8a [KO:K00714]
106985205  protein Wnt-9a isoform X1 [KO:K01064]
106988831  protein Wnt-9b [KO:K01064]
106970053  protein Wnt-10a [KO:K01357]
106969331  protein Wnt-10b [KO:K01357]
106976446  protein Wnt-11 [KO:K01384]
106970656  protein Wnt-16 [KO:K01558]
106978285  frizzled-7 [KO:K02432]
106987276  frizzled-1 [KO:K02432]
106974284  frizzled-2 [KO:K02235]
106983024  frizzled-3 isoform X2 [KO:K02329]
106967740  frizzled-4 [KO:K02354]
106967100  frizzled-5 [KO:K02375]
113603657  frizzled-8 [KO:K02375]
106980059  frizzled-6 [KO:K02376]
106986936  frizzled-10 [KO:K02842]
106980711  frizzled-9 [KO:K02842]
106965642  low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
106971089  low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
106988759  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
106983787  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
106972415  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
106968274  glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
106983958  tumor necrosis factor [KO:K03156]
106965450  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106990012  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
113595531  insulin [KO:K04526]
106971906  insulin-like growth factor I isoform X4 [KO:K05459]
106979040  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
106975144  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
106987795  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
106978987  son of sevenless homolog 1 isoform X1 [KO:K03099]
106989073  son of sevenless homolog 2 isoform X1 [KO:K03099]
106987957  GTPase HRas isoform X1 [KO:K02833]
106968778  GTPase KRas isoform X1 [KO:K07827]
106969596  GTPase NRas [KO:K07828]
106970441  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
106977129  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106980282  dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
106975474  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106969232  mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
106990008  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106977560  ribosomal protein S6 kinase alpha-1 isoform X4 [KO:K04373] [EC:2.7.11.1]
106986817  ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
106985519  ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
106985018  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
106972296  insulin receptor substrate 1 [KO:K16172]
106976917  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106973297  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106969150  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106984896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106984265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106973880  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106980972  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X4 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106978772  3-phosphoinositide-dependent protein kinase 1 isoform X5 [KO:K06276] [EC:2.7.11.1]
106979622  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106975558  RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
106985046  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106966935  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106965412  target of rapamycin complex 2 subunit MAPKAP1 isoform X3 [KO:K20410]
106970918  rapamycin-insensitive companion of mTOR isoform X4 [KO:K08267]
106967309  proline-rich protein 5 isoform X4 [KO:K20411]
106976939  proline-rich protein 5-like isoform X1 [KO:K20411]
106979239  transforming protein RhoA [KO:K04513]
106975306  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106970449  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106980855  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
106976864  serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
aju00561  Glycerolipid metabolism
aju04010  MAPK signaling pathway
aju04140  Autophagy - animal
aju04151  PI3K-Akt signaling pathway
aju04152  AMPK signaling pathway
aju04810  Regulation of actin cytoskeleton
aju04910  Insulin signaling pathway
KO pathway
ko04150   
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