KEGG   PATHWAY: anu04530
Entry
anu04530                    Pathway                                
Name
Tight junction - Arvicanthis niloticus (African grass rat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
anu04530  Tight junction
anu04530

Other DBs
GO: 0005923
Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117705498  Crb3; protein crumbs homolog 3 [KO:K06090]
117720853  Cldn12; claudin-12 [KO:K06087]
117722060  claudin-22-like [KO:K06087]
117711467  Cldn6; claudin-6 [KO:K06087]
117711550  Cldn9; claudin-9 [KO:K06087]
117711646  Cldn7; claudin-7 [KO:K06087]
117697673  Cldn4; claudin-4 [KO:K06087]
117705465  Cldn10; claudin-10 isoform X1 [KO:K06087]
117698041  Cldn3; claudin-3 [KO:K06087]
117698088  claudin-13-like [KO:K06087]
117698089  claudin-13-like [KO:K06087]
117698090  claudin-13-like [KO:K06087]
117698091  claudin-13-like [KO:K06087]
117698174  Cldn15; claudin-15 [KO:K06087]
117698869  Cldn25; putative claudin-25 [KO:K06087]
117706978  Cldn11; claudin-11 [KO:K06087]
117717839  Cldn5; claudin-5 [KO:K06087]
117700167  Cldn20; claudin-20 [KO:K06087]
117708198  Cldn19; claudin-19 [KO:K06087]
117717897  Cldn17; claudin-17 [KO:K06087]
117717922  Cldn14; claudin-14 isoform X1 [KO:K06087]
117717931  Cldn8; claudin-8 [KO:K06087]
117718096  Cldn16; claudin-16 [KO:K06087]
117718227  Cldn1; LOW QUALITY PROTEIN: claudin-1 [KO:K06087]
117693587  Cldn18; claudin-18 isoform X1 [KO:K06087]
117693950  Cldn2; claudin-2 [KO:K06087]
117693995  claudin-34-like [KO:K06087]
117694026  claudin-34-like [KO:K06087]
117694071  claudin-34-like [KO:K06087]
117721466  claudin-22 [KO:K06087]
117721602  Cldn23; claudin-23 [KO:K06087]
117724046  Ocln; occludin isoform X1 [KO:K06088]
117722065  F11r; junctional adhesion molecule A [KO:K06089]
117717802  Jam2; junctional adhesion molecule B [KO:K06735]
117714250  Jam3; junctional adhesion molecule C [KO:K06785]
117724139  Bves; blood vessel epicardial substance [KO:K21108]
117708461  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117704526  Pard6b; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
117723270  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
117720011  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
117697171  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
117705306  Mpp4; LOW QUALITY PROTEIN: MAGUK p55 subfamily member 4 [KO:K21109]
117696500  Tjp3; tight junction protein ZO-3 [KO:K06097]
117709374  Mpdz; multiple PDZ domain protein isoform X1 [KO:K06095]
117708435  Prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
117706861  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117695267  Amot; angiomotin [KO:K16819]
117699736  Amotl1; angiomotin-like protein 1 isoform X1 [KO:K06104]
117693270  Amotl2; angiomotin-like protein 2 [KO:K06104]
117717217  Arhgap17; rho GTPase-activating protein 17 [KO:K20638]
117697870  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117712362  Nf2; merlin isoform X1 [KO:K16684]
117709982  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
117710525  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
117718155  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
117718883  Scrib; protein scribble homolog isoform X1 [KO:K16175]
117709998  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117721629  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117699505  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
117700879  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
117705373  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
117719763  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
117710161  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
117712931  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
117722857  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
117717813  Tiam1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
117703064  Tjp1; tight junction protein ZO-1 isoform X1 [KO:K05701]
117722216  Tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
117693998  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
117694133  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
117699624  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
117719576  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
117707648  Cgn; cingulin [KO:K06102]
117699876  Cgnl1; cingulin-like protein 1 [KO:K21110]
117706621  Arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
117715446  transforming protein RhoA-like [KO:K04513]
117725075  Rhoa; transforming protein RhoA [KO:K04513]
117705928  Gata4; transcription factor GATA-4 isoform X1 [KO:K09183]
117723019  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
117723859  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
117705037  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117709966  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117709069  Jun; transcription factor AP-1 [KO:K04448]
117707124  antigen-presenting glycoprotein CD1d-like isoform X1 [KO:K06448]
117707261  antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
117707352  antigen-presenting glycoprotein CD1d-like [KO:K06448]
117720697  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
117696408  Cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
117714789  Ybx3; Y-box-binding protein 3 [KO:K06099]
117715097  Y-box-binding protein 3-like [KO:K06099]
117697736  Y-box-binding protein 3-like [KO:K06099]
117697753  Y-box-binding protein 3-like [KO:K06099]
117705700  Y-box-binding protein 3-like [KO:K06099]
117716050  Y-box-binding protein 3-like [KO:K06099]
117716394  Y-box-binding protein 3-like [KO:K06099]
117716396  Y-box-binding protein 3-like [KO:K06099]
117716401  Y-box-binding protein 3-like [KO:K06099]
117723434  Y-box-binding protein 3-like [KO:K06099]
117723435  Y-box-binding protein 3-like [KO:K06099]
117723436  Y-box-binding protein 3-like [KO:K06099]
117698876  Y-box-binding protein 3-like [KO:K06099]
117698883  Y-box-binding protein 3-like [KO:K06099]
117701283  Y-box-binding protein 3-like [KO:K06099]
117701300  Y-box-binding protein 3-like [KO:K06099]
117708789  Y-box-binding protein 3-like [KO:K06099]
117701536  Y-box-binding protein 3-like [KO:K06099]
117701643  Y-box-binding protein 3-like [KO:K06099]
117702398  Y-box-binding protein 3-like [KO:K06099]
117695021  Y-box-binding protein 3-like [KO:K06099]
117710369  Y-box-binding protein 3-like [KO:K06099]
117713396  Y-box-binding protein 3-like [KO:K06099]
117695732  Y-box-binding protein 3-like [KO:K06099]
117696029  Y-box-binding protein 3-like [KO:K06099]
117696085  Y-box-binding protein 3-like [KO:K06099]
117708142  Sympk; symplekin isoform X1 [KO:K06100]
117704518  Pcna; proliferating cell nuclear antigen [KO:K04802]
117711496  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
117710649  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
117717806  Runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
117710038  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
117711668  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
117700121  Ezr; ezrin isoform X1 [KO:K08007]
117699413  Rdx; radixin [KO:K05762]
117694351  Msn; moesin [KO:K05763]
117717018  Prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
117697924  Actb; actin, cytoplasmic 1 [KO:K05692]
117710865  Actg1; actin, cytoplasmic 2 [KO:K05692]
117705045  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117701010  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117697775  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117703400  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117706998  Cttn; src substrate cortactin isoform X1 [KO:K06106]
117717805  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
117712651  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
117716097  Actr3; actin-related protein 3 [KO:K18584]
117720567  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
117697994  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117698281  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117705773  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117697653  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117714669  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117716311  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
117703049  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
117698079  Whamm; WASP homolog-associated protein with actin, membranes and microtubules isoform X1 [KO:K20479]
117694799  Was; wiskott-Aldrich syndrome protein [KO:K05747]
117717352  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117723055  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117706647  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117706701  Rab13; ras-related protein Rab-13 isoform X1 [KO:K06109]
117698074  Arhgef18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
117719597  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
117716790  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
117698422  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
117709330  Epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
117696120  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117723868  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117708512  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117698037  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
117707094  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
117705444  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
117719091  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117720702  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
117719233  Myh9; myosin-9 [KO:K10352]
117710172  Myh11; myosin-11 isoform X1 [KO:K10352]
117711001  Myh10; myosin-10 isoform X1 [KO:K10352]
117713822  Myh14; myosin-14 isoform X1 [KO:K10352]
117696658  Myl6b; myosin light chain 6B [KO:K12751]
117696659  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
117704222  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
117693346  myosin regulatory light chain RLC-A [KO:K12757]
117693665  myosin regulatory light chain 12B [KO:K12757]
117694454  myosin regulatory light chain 12B-like [KO:K12757]
117717659  Igsf5; immunoglobulin superfamily member 5 [KO:K06786]
117714733  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
117719734  Synpo; synaptopodin isoform X1 [KO:K21112]
117697098  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
117721403  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
117697693  Micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
117721534  Rab8a; ras-related protein Rab-8A [KO:K07901]
117699482  Rab8b; ras-related protein Rab-8B [KO:K07902]
117711427  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
117707587  Rap1a; ras-related protein Rap-1A [KO:K04353]
117723085  Itgb1; integrin beta-1 [KO:K05719]
117700252  Afdn; afadin isoform X1 [KO:K05702]
117710400  Tjp2; tight junction protein ZO-2 isoform X1 [KO:K06098]
117707165  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117694817  Rap2c; ras-related protein Rap-2c [KO:K07839]
117723751  Marveld2; MARVEL domain-containing protein 2 [KO:K17291]
117714897  tubulin alpha-3 chain [KO:K07374]
117714960  tubulin alpha-3 chain isoform X1 [KO:K07374]
117715120  Tuba8; tubulin alpha-8 chain [KO:K07374]
117705322  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
117712095  tubulin alpha chain-like [KO:K07374]
117718493  Tuba1a; tubulin alpha-1A chain [KO:K07374]
117718494  Tuba1b; tubulin alpha-1B chain [KO:K07374]
117718519  tubulin alpha-1C chain [KO:K07374]
117714111  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
anu04520  Adherens junction
anu04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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