KEGG   PATHWAY: bman03040
Entry
bman03040                   Pathway                                
Name
Spliceosome - Bombyx mandarina (wild silkworm)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
bman03040  Spliceosome
bman03040

Other DBs
GO: 0005681
Organism
Bombyx mandarina (wild silkworm) [GN:bman]
Gene
114250106  U1 spliceosomal RNA [KO:K14276]
114250070  U1 spliceosomal RNA [KO:K14276]
114248704  U1 spliceosomal RNA [KO:K14276]
114244487  U2 spliceosomal RNA [KO:K14277]
114242766  U2 spliceosomal RNA [KO:K14277]
114244490  U2 spliceosomal RNA [KO:K14277]
114244484  U2 spliceosomal RNA [KO:K14277]
114250176  U4 spliceosomal RNA [KO:K14278]
114253420  U4 spliceosomal RNA [KO:K14278]
114250457  U4 spliceosomal RNA [KO:K14278]
114250364  U4 spliceosomal RNA [KO:K14278]
114240234  U5 spliceosomal RNA [KO:K14279]
114240233  U5 spliceosomal RNA [KO:K14279]
114242689  U5 spliceosomal RNA [KO:K14279]
114243423  U5 spliceosomal RNA [KO:K14279]
114241273  U6 spliceosomal RNA [KO:K14280]
114239521  U6 spliceosomal RNA [KO:K14280]
114240861  U6 spliceosomal RNA [KO:K14280]
114245029  U6 spliceosomal RNA [KO:K14280]
114249345  U6 spliceosomal RNA [KO:K14280]
114248037  U6 spliceosomal RNA [KO:K14280]
114239660  U6 spliceosomal RNA [KO:K14280]
114240559  U6 spliceosomal RNA [KO:K14280]
114241432  U6 spliceosomal RNA [KO:K14280]
114251604  U6 spliceosomal RNA [KO:K14280]
114244131  probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
114243661  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
114248388  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
114243326  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
114247368  pre-mRNA-processing factor 17 [KO:K12816]
114246478  pre-mRNA-splicing factor 18 [KO:K12817]
114248902  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
114251961  pre-mRNA-splicing factor Slu7 [KO:K12819]
114244169  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
114248970  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
114243461  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
114241505  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
114246749  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
114243309  probable small nuclear ribonucleoprotein E isoform X1 [KO:K11097]
114241364  small nuclear ribonucleoprotein F-like [KO:K11098]
114241401  small nuclear ribonucleoprotein F-like [KO:K11098]
114253522  probable small nuclear ribonucleoprotein G [KO:K11099]
114243897  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
114240793  U1 small nuclear ribonucleoprotein C [KO:K11095]
114244752  pre-mRNA-processing factor 40 homolog A [KO:K12821]
114244712  pre-mRNA-processing factor 40 homolog B-like [KO:K12821]
114244128  LOW QUALITY PROTEIN: RNA-binding protein 25-like [KO:K12822]
114242285  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
114247499  ATP-dependent RNA helicase p62 isoform X1 [KO:K12823] [EC:5.6.2.7]
114247532  ATP-dependent RNA helicase DBP2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
114243835  transcription elongation regulator 1 isoform X1 [KO:K12824]
114251379  RNA-binding protein cabeza-like isoform X1 [KO:K13098]
114249001  U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092]
114239959  splicing factor 3A subunit 1 [KO:K12825]
114250835  splicing factor 3A subunit 2 [KO:K12826]
114241398  splicing factor 3A subunit 3 [KO:K12827]
114251214  splicing factor 3B subunit 1 [KO:K12828]
114243941  splicing factor 3B subunit 2 [KO:K12829]
114247547  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
114245057  splicing factor 3B subunit 5 [KO:K12832]
114248592  splicing factor 3B subunit 6 [KO:K12833]
114247273  PHD finger-like domain-containing protein 5A [KO:K12834]
114247269  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
114246097  splicing factor U2af 38 kDa subunit [KO:K12836]
114240610  splicing factor U2AF 50 kDa subunit isoform X1 [KO:K12837]
114240303  poly(U)-binding-splicing factor half pint [KO:K12838]
114249395  survival of motor neuron-related-splicing factor 30 [KO:K12839]
114249272  splicing factor 45 [KO:K12840]
114243027  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
114242851  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
114249790  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
114244146  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
114250472  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
114240607  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
114240923  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
114251582  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
114246497  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
114248467  U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
114248484  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
114248731  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
114243223  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
114251531  NHP2-like protein 1 [KO:K12845]
114248448  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
114245480  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
114247291  U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984]
114244770  zinc finger matrin-type protein 2 [KO:K12848]
114243368  pre-mRNA-splicing factor 38 [KO:K12849]
114242638  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
114242553  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
114244133  pre-mRNA-processing factor 6 [KO:K12855]
114242990  pre-mRNA-processing-splicing factor 8 [KO:K12856]
114244043  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
114245778  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
114248017  thioredoxin-like protein 4A [KO:K12859]
114247030  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
114239730  cell division cycle 5-like protein [KO:K12860]
114243680  pre-mRNA-splicing factor SPF27 [KO:K12861]
114246962  pleiotropic regulator 1 isoform X1 [KO:K12862]
114251782  protein CWC15 homolog [KO:K12863]
114248228  beta-catenin-like protein 1 [KO:K12864]
114252937  heat shock 70 kDa protein cognate 2-like [KO:K03283]
114252521  heat shock protein 68-like isoform X1 [KO:K03283]
114253502  heat shock protein 68-like isoform X1 [KO:K03283]
114253503  heat shock protein 68-like [KO:K03283]
114245244  heat shock 70 kDa protein cognate 4 [KO:K03283]
114251668  heat shock protein 68-like [KO:K03283]
114245846  polyglutamine-binding protein 1 [KO:K12865]
114248030  puff-specific protein Bx42 [KO:K06063]
114244582  pre-mRNA-splicing factor SYF1 [KO:K12867]
114242407  pre-mRNA-splicing factor Syf2 [KO:K12868]
114246354  protein crooked neck [KO:K12869]
114245938  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
114246736  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1 [KO:K12733] [EC:5.2.1.8]
114248573  peptidyl-prolyl cis-trans isomerase [KO:K09564] [EC:5.2.1.8]
114247589  coiled-coil domain-containing protein 12 [KO:K12871]
114241499  pre-mRNA-splicing factor RBM22 [KO:K12872]
114245391  protein BUD31 homolog [KO:K12873]
114247839  RNA helicase aquarius isoform X1 [KO:K12874]
114243954  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
114241900  RNA-binding protein 8A [KO:K12876]
114250339  protein mago nashi homolog [KO:K12877]
114241392  THO complex subunit 1 [KO:K12878]
114245339  THO complex subunit 2 [KO:K12879]
114241506  THO complex subunit 3 [KO:K12880]
114249920  THO complex subunit 4 [KO:K12881]
114251102  nuclear cap-binding protein subunit 1 [KO:K12882]
114252728  nuclear cap-binding protein subunit 2 [KO:K12883]
114239873  heterogeneous nuclear ribonucleoprotein 87F-like [KO:K12741]
114239941  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [KO:K12741]
114239288  heterogeneous nuclear ribonucleoprotein K [KO:K12886]
114246308  serine/arginine-rich splicing factor 1A [KO:K12890]
114253314  serine/arginine-rich splicing factor 2 [KO:K12891]
114242899  serine-arginine protein 55 isoform X1 [KO:K12893]
114245921  serine/arginine-rich splicing factor 7-like [KO:K12896]
114242579  RNA-binding protein 1 isoform X1 [KO:K12896]
114247246  transformer-2 protein homolog beta isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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