Entry
Name
AMPK signaling pathway - Balaenoptera musculus (blue whale)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Balaenoptera musculus (blue whale) [GN:
bmus ]
Gene
118886821 STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
118897932 STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532 ]
118888575 LOW QUALITY PROTEIN: adiponectin receptor protein 1-like [KO:K07297 ]
118890467 LOW QUALITY PROTEIN: adiponectin receptor protein 2-like [KO:K07297 ]
118898524 PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199 ]
118906832 PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199 ]
118898407 PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200 ]
118900839 PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
118902461 PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
118906201 CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333 ]
118898344 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
118898110 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
118898829 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048 ]
118893647 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
118900696 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
118896763 CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
118900738 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
118895621 PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202 ]
118886981 SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191 ]
118887057 SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197 ]
118892240 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
118885093 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
118899952 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456 ]
118886659 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354 ]
118893486 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
118895412 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
118883039 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354 ]
118896575 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
118906324 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like [KO:K11583 ]
118894234 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
118890272 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
118888640 PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583 ]
118904165 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
118899903 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584 ]
118888336 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
118890079 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
118884194 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584 ]
118890818 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
118892181 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118894592 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
118894671 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118891709 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
118892996 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
118901944 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
118886692 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
118887997 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
118903688 PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
Compound
C00354 D-Fructose 1,6-bisphosphate
C00665 beta-D-Fructose 2,6-bisphosphate
C00668 alpha-D-Glucose 6-phosphate
C01172 beta-D-Glucose 6-phosphate
C04677 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C09731 Epigallocatechin gallate
Reference
Authors
Steinberg GR, Kemp BE
Title
AMPK in Health and Disease.
Journal
Reference
Authors
Hardie DG.
Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
Journal
Reference
Authors
Russo GL, Russo M, Ungaro P
Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
Journal
Reference
Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
Title
AMPK in the brain: its roles in energy balance and neuroprotection.
Journal
Reference
Authors
Li J, McCullough LD
Title
Effects of AMP-activated protein kinase in cerebral ischemia.
Journal
Reference
Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
Journal
Reference
Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
Journal
Reference
Authors
Shackelford DB, Shaw RJ
Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
Journal
Reference
Authors
Chung JH, Manganiello V, Dyck JR
Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
Journal
Reference
Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Journal
Reference
Authors
Towler MC, Hardie DG
Title
AMP-activated protein kinase in metabolic control and insulin signaling.
Journal
Reference
Authors
Richter EA, Hargreaves M
Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
Journal
Reference
Authors
Kahn BB, Alquier T, Carling D, Hardie DG
Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Journal
Reference
Authors
Minokoshi Y, Toda C, Okamoto S
Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
Journal
Reference
Authors
Guggino WB, Stanton BA
Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
Journal
Reference
Authors
Cheng A, Saltiel AR
Title
More TORC for the gluconeogenic engine.
Journal
Reference
Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
Journal
Reference
Authors
Morris DL, Rui L
Title
Recent advances in understanding leptin signaling and leptin resistance.
Journal
Reference
Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
Title
Role of hypothalamic AMP-kinase in food intake regulation.
Journal
Reference
Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Journal
Related pathway
bmus01040 Biosynthesis of unsaturated fatty acids
KO pathway
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