Entry Name GnRH secretion - Bos mutus (wild yak)
Description Hypothalamic gonadotropin-releasing hormone (GnRH) neurons are key regulators of reproduction. They release GnRH into the portal circulation. In turn, GnRH stimulates the pituitary gland to secrete follicle-stimulating hormone and luteinizing hormone (LH) to regulate gonadal functions. Gonadal steroids provide feedback to regulate GnRH release. GnRH neurons express the kisspeptin receptor, GPR 54, and kisspeptins potently stimulate the release of GnRH by depolarising and inducing sustained action potential firing in GnRH neurons. It is also demonstrated that Kisspeptin-GPR54 system positively regulates the GnRH expression with a time course consistent with activation of Akt and MAP kinase signaling pathways.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Ortholog table Organism Bos mutus (wild yak) [GN:
bom ]
Gene 102281593 HCN1; hyperpolarization activated cyclic nucleotide gated potassium channel 1 [KO:K04954 ]
102279911 HCN2; hyperpolarization activated cyclic nucleotide gated potassium channel 2 [KO:K04955 ]
102273426 HCN3; hyperpolarization activated cyclic nucleotide gated potassium channel 3 [KO:K04956 ]
102280279 CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854 ]
102276868 CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855 ]
102272298 CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856 ]
102267739 TRPC1; transient receptor potential cation channel subfamily C member 1 [KO:K04964 ]
102267732 TRPC4; transient receptor potential cation channel subfamily C member 4 [KO:K04967 ]
102276500 TRPC5; transient receptor potential cation channel subfamily C member 5 [KO:K04968 ]
102271347 KCNJ11; potassium voltage-gated channel subfamily J member 11 [KO:K05004 ]
102269266 KCNJ3; potassium voltage-gated channel subfamily J member 3 [KO:K04997 ]
102274100 KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000 ]
102271283 KCNJ9; potassium voltage-gated channel subfamily J member 9 [KO:K05002 ]
102266376 KCNJ5; potassium voltage-gated channel subfamily J member 5 [KO:K04999 ]
102266885 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
102269438 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615 ]
102282462 KCNN1; potassium calcium-activated channel subfamily N member 1 [KO:K04942 ]
102270681 KCNN2; potassium calcium-activated channel subfamily N member 2 [KO:K04943 ]
102264487 KCNN3; potassium calcium-activated channel subfamily N member 3 [KO:K04944 ]
102270776 KCNN4; potassium calcium-activated channel subfamily N member 4 [KO:K04945 ]
102272241 CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857 ]
102277590 CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850 ]
102271623 CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851 ]
102286805 CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853 ]
102266922 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
102280296 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
102286868 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Reference Authors Ronnekleiv OK, Kelly MJ
Title Kisspeptin excitation of GnRH neurons.
Journal Reference Authors Beltramo M, Dardente H, Cayla X, Caraty A
Title Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin.
Journal Reference Authors Oakley AE, Clifton DK, Steiner RA
Title Kisspeptin signaling in the brain.
Journal Reference Authors Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M
Title Kisspeptins and reproduction: physiological roles and regulatory mechanisms.
Journal Reference Authors d'Anglemont de Tassigny X, Colledge WH
Title The role of kisspeptin signaling in reproduction.
Journal Reference Authors Tena-Sempere M
Title Kisspeptin signaling in the brain: recent developments and future challenges.
Journal Reference Authors Colledge WH
Title Kisspeptins and GnRH neuronal signalling.
Journal Reference Authors Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, Tena-Sempere M
Title Kisspeptins and the control of gonadotropin secretion in male and female rodents.
Journal Reference Authors Piet R, de Croft S, Liu X, Herbison AE
Title Electrical properties of kisspeptin neurons and their regulation of GnRH neurons.
Journal Reference Authors Zhang C, Bosch MA, Ronnekleiv OK, Kelly MJ
Title Kisspeptin activation of TRPC4 channels in female GnRH neurons requires PIP2 depletion and cSrc kinase activation.
Journal Reference Authors Ronnekleiv OK, Bosch MA, Zhang C
Title Regulation of endogenous conductances in GnRH neurons by estrogens.
Journal Reference Authors Ronnekleiv OK, Zhang C, Bosch MA, Kelly MJ
Title Kisspeptin and Gonadotropin-Releasing Hormone Neuronal Excitability: Molecular Mechanisms Driven by 17beta-Estradiol.
Journal Reference Authors Zhang XB, Spergel DJ
Title Kisspeptin inhibits high-voltage activated Ca2+ channels in GnRH neurons via multiple Ca2+ influx and release pathways.
Journal Reference Authors Novaira HJ, Ng Y, Wolfe A, Radovick S
Title Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines.
Journal Reference Authors Glanowska KM, Moenter SM
Title Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice.
Journal Reference Authors Szereszewski JM, Pampillo M, Ahow MR, Offermanns S, Bhattacharya M, Babwah AV
Title GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Galpha(q/11) and beta-arrestin-dependent manner.
Journal Reference Authors Zhang C, Bosch MA, Rick EA, Kelly MJ, Ronnekleiv OK
Title 17Beta-estradiol regulation of T-type calcium channels in gonadotropin-releasing hormone neurons.
Journal Reference Authors Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson MA, Makino H
Title Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells.
Journal Reference Authors Radovick S, Levine JE, Wolfe A
Title Estrogenic regulation of the GnRH neuron.
Journal Reference Authors Dungan HM, Clifton DK, Steiner RA
Title Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion.
Journal Reference Authors Kato M, Tanaka N, Usui S, Sakuma Y
Title The SK channel blocker apamin inhibits slow afterhyperpolarization currents in rat gonadotropin-releasing hormone neurones.
Journal Reference Authors Zhang C, Ronnekleiv OK, Kelly MJ
Title Kisspeptin inhibits a slow afterhyperpolarization current via protein kinase C and reduces spike frequency adaptation in GnRH neurons.
Journal Related KO pathway LinkDB All DBs
