KEGG   PATHWAY: bom04020
Entry
bom04020                    Pathway                                
Name
Calcium signaling pathway - Bos mutus (wild yak)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
bom04020  Calcium signaling pathway
bom04020

Other DBs
GO: 0019722
Organism
Bos mutus (wild yak) [GN:bom]
Gene
102264349  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102264452  EDNRA; endothelin-1 receptor [KO:K04197]
102264471  SLC8A1; sodium/calcium exchanger 1 isoform X3 [KO:K05849]
102264521  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
102264532  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102264662  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102264670  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102264869  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102264884  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102264981  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102264989  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102265099  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102265198  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5 [KO:K13755] [EC:3.1.4.17]
102265554  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102265630  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
102265770  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
102265783  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102265831  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102265893  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
102266024  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102266153  [KO:K04632]
102266155  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
102266290  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102266295  [KO:K02183]
102266307  TACR2; substance-K receptor [KO:K04223]
102266592  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102266749  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102266763  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102266839  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102266852  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102266916  VDAC1; non-selective voltage-gated ion channel VDAC1 [KO:K05862]
102266966  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102267116  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102267139  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
102267356  GRPR; gastrin-releasing peptide receptor [KO:K04169]
102267381  AVPR1B; vasopressin V1b receptor [KO:K04227]
102267440  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
102267556  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
102267776  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102267813  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102267837  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102267975  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102267985  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102268061  CALM2; calmodulin-2 isoform X2 [KO:K02183]
102268062  TBXA2R; thromboxane A2 receptor [KO:K04264]
102268185  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
102268290  ADORA2B; adenosine receptor A2b [KO:K04267]
102268378  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
102268410  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
102268455  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
102268465  MCOLN2; mucolipin-2 [KO:K04993]
102268648  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
102268851  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
102269013  ITPR2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
102269080  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
102269088  ITPR1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
102269089  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102269124  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102269125  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
102269433  ATP2B3; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
102269437  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102269641  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
102269657  [KO:K02183]
102269660  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102269744  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102269828  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102269868  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102269922  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102270254  TPCN2; LOW QUALITY PROTEIN: two pore channel protein 2 [KO:K14077]
102270277  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
102270402  ADRB1; beta-1 adrenergic receptor [KO:K04141]
102270607  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
102270608  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
102270743  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102270828  FGF19; fibroblast growth factor 19 [KO:K22603]
102270847  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X5 [KO:K05850] [EC:7.2.2.10]
102270854  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
102270875  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102271039  ITPR3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 [KO:K04960]
102271113  FGF4; fibroblast growth factor 4 [KO:K04358]
102271178  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
102271219  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102271262  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2 [KO:K07190]
102271361  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102271367  SLN; sarcolipin [KO:K22642]
102271394  FGF3; fibroblast growth factor 3 [KO:K04358]
102271451  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
102271623  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X5 [KO:K04851]
102271803  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102271938  STIM1; stromal interaction molecule 1 isoform X4 [KO:K16059]
102271961  [KO:K02183]
102271993  FGF10; fibroblast growth factor 10 [KO:K04358]
102272008  FGF6; fibroblast growth factor 6 [KO:K04358]
102272042  OXTR; oxytocin receptor [KO:K04229]
102272241  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102272271  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102272298  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102272347  F2R; proteinase-activated receptor 1 [KO:K03914]
102272403  CASQ1; calsequestrin-1 [KO:K23468]
102272478  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
102272710  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
102272741  [KO:K04809]
102272964  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102273043  HRH1; histamine H1 receptor [KO:K04149]
102273267  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102273282  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
102273347  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102273490  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
102273574  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102273668  FGF9; fibroblast growth factor 9 [KO:K04358]
102273820  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102274116  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102274117  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102274230  [KO:K16056]
102274299  FGF23; fibroblast growth factor 23 [KO:K22428]
102274303  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
102274384  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102274558  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
102274680  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
102274702  FGF20; fibroblast growth factor 20 [KO:K04358]
102275057  ADORA2A; adenosine receptor A2a [KO:K04266]
102275085  TACR1; substance-P receptor [KO:K04222]
102275553  ORAI3; protein orai-3 [KO:K16058]
102275567  RYR1; ryanodine receptor 1 [KO:K04961]
102275601  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102275745  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
102275761  MCOLN3; mucolipin-3 isoform X2 [KO:K04994]
102275863  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102275883  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102275926  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102275932  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102275962  P2RX2; P2X purinoceptor 2 [KO:K05216]
102276010  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
102276054  HTR5A; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5A [KO:K04161]
102276211  P2RX4; P2X purinoceptor 4 [KO:K05218]
102276260  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
102276267  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
102276558  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
102276600  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102276673  [KO:K05862]
102276868  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102276953  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102277347  DRD1; D(1A) dopamine receptor [KO:K04144]
102277590  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102277605  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102277668  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
102277736  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102277836  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
102277862  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
102277870  DRD5; D(1B) dopamine receptor [KO:K05840]
102277937  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
102278016  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
102278227  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
102278484  PLN; cardiac phospholamban [KO:K05852]
102278561  P2RX1; P2X purinoceptor 1 isoform X2 [KO:K05215]
102278698  MST1R; LOW QUALITY PROTEIN: macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
102278724  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102278785  ORAI2; protein orai-2 [KO:K16057]
102278896  TNNC2; troponin C, skeletal muscle [KO:K12042]
102278948  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102279034  FGF16; fibroblast growth factor 16 [KO:K04358]
102279045  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
102279229  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
102279381  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
102279772  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
102280002  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
102280125  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102280127  CCKAR; cholecystokinin receptor type A [KO:K04194]
102280240  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
102280279  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102280361  [KO:K02183]
102280395  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
102280425  BDKRB2; B2 bradykinin receptor [KO:K03916]
102280537  NOS1; nitric oxide synthase 1 isoform X2 [KO:K13240] [EC:1.14.13.39]
102280707  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
102280853  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102280888  AVPR1A; vasopressin V1a receptor [KO:K04226]
102280941  VEGFC; vascular endothelial growth factor C [KO:K05449]
102280999  RYR2; ryanodine receptor 2 [KO:K04962]
102281006  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
102281077  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
102281085  EDNRB; endothelin receptor type B [KO:K04198]
102281153  [KO:K04282]
102281308  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102281314  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102281423  PTAFR; platelet-activating factor receptor [KO:K04279]
102281520  [KO:K04282]
102281667  CALM1; calmodulin-1 isoform X1 [KO:K02183]
102281757  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102281822  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102281864  P2RX3; P2X purinoceptor 3 [KO:K05217]
102281905  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102282196  P2RX7; LOW QUALITY PROTEIN: P2X purinoceptor 7 [KO:K05220]
102282265  FGF21; fibroblast growth factor 21 [KO:K22429]
102282456  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102282476  CALM3; calmodulin-3 [KO:K02183]
102282524  TRDN; triadin isoform X1 [KO:K23449]
102282598  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102282732  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102282911  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
102283195  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102283501  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
102283599  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
102283831  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
102284101  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
102284112  MCOLN1; mucolipin-1 [KO:K04992]
102284142  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
102284406  CALML4; calmodulin-like protein 4 [KO:K02183]
102284420  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
102284455  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
102284539  TPCN1; LOW QUALITY PROTEIN: two pore channel protein 1 [KO:K16896]
102284554  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
102284897  FGF2; fibroblast growth factor 2 [KO:K18497]
102284923  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102284948  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
102285100  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
102285123  SPHK1; sphingosine kinase 1 isoform X4 [KO:K04718] [EC:2.7.1.91]
102285300  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102285411  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102285474  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102285634  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102285642  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102285914  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102285919  ADRA1B; LOW QUALITY PROTEIN: alpha-1B adrenergic receptor [KO:K04136]
102285921  ARLN; uncharacterized protein C4orf3 homolog [KO:K26467]
102285968  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102286083  FGF7; fibroblast growth factor 7 [KO:K04358]
102286123  [KO:K04632]
102286168  ADCY4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102286445  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102286523  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
102286625  TACR3; neuromedin-K receptor [KO:K04224]
102286650  NTSR1; neurotensin receptor type 1 [KO:K04211]
102286708  ERLN; small integral membrane protein 6 [KO:K26468]
102286752  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102286805  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102287077  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102287133  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
102287147  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
102287270  FGF18; fibroblast growth factor 18 [KO:K04358]
102287352  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102287374  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
102287375  [KO:K02183]
102287414  [KO:K04634]
102287477  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
102287542  CASQ2; calsequestrin-2 [KO:K23445]
102287572  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102287661  GNA11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102287715  TFEB; transcription factor EB [KO:K15590]
102287774  [KO:K04161]
102287887  ADRB2; beta-2 adrenergic receptor [KO:K04142]
102288004  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102288007  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102288136  P2RX5; P2X purinoceptor 5 isoform X4 [KO:K05219]
106700756  MRLN; myoregulin isoform X2 [KO:K22643]
138989375  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
bom04010  MAPK signaling pathway
bom04070  Phosphatidylinositol signaling system
bom04210  Apoptosis
bom04720  Long-term potentiation
bom04730  Long-term depression
KO pathway
ko04020   

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