KEGG   PATHWAY: bom04010
Entry
bom04010                    Pathway                                
Name
MAPK signaling pathway - Bos mutus (wild yak)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
bom04010  MAPK signaling pathway
bom04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Bos mutus (wild yak) [GN:bom]
Gene
102264458  DAXX; LOW QUALITY PROTEIN: death domain-associated protein 6 [KO:K02308]
102264559  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102264620  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102264669  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
102264670  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102264750  RASGRP2; RAS guanyl-releasing protein 2 isoform X3 [KO:K12361]
102264816  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102264869  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102264981  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102265023  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102265273  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
102265384  RAP1B; ras-related protein Rap-1b [KO:K07836]
102265427  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102265546  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102265554  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102265567  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102265606  CACNB3; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
102265783  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102265831  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102265990  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
102266032  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
102266290  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102266310  CDC42; cell division control protein 42 homolog [KO:K04393]
102266369  STMN1; stathmin [KO:K04381]
102266520  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
102266749  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102266763  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102266766  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102266839  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102266863  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
102266960  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102266971  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102266978  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102267018  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102267127  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
102267130  ANGPT1; angiopoietin-1 [KO:K05465]
102267423  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102267592  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102267601  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102267773  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102267776  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102267813  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102267837  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102267874  EFNA1; ephrin-A1 [KO:K05462]
102267895  JUN; transcription factor Jun [KO:K04448]
102267975  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102267985  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102268339  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
102268417  RELA; transcription factor p65 [KO:K04735]
102268507  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3 [KO:K04858]
102268519  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102268978  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
102269089  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102269124  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102269203  NRAS; GTPase NRas [KO:K07828]
102269496  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
102269500  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
102269548  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102269650  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102269660  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102269710  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102269741  [KO:K04381]
102269744  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102269800  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102269868  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102270134  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
102270413  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102270488  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
102270607  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
102270608  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
102270620  MAPT; microtubule-associated protein tau isoform X9 [KO:K04380]
102270743  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102270828  FGF19; fibroblast growth factor 19 [KO:K22603]
102270841  AREG; amphiregulin [KO:K09782]
102271030  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102271047  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102271113  FGF4; fibroblast growth factor 4 [KO:K04358]
102271186  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102271219  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102271320  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102271361  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102271394  FGF3; fibroblast growth factor 3 [KO:K04358]
102271481  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
102271527  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102271586  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
102271611  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
102271616  HSPB1; heat shock protein beta-1 [KO:K04455]
102271623  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X5 [KO:K04851]
102271639  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102271710  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
102271863  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102271993  FGF10; fibroblast growth factor 10 [KO:K04358]
102272008  FGF6; fibroblast growth factor 6 [KO:K04358]
102272009  IGF1; insulin-like growth factor 1 isoform X3 [KO:K05459]
102272113  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102272140  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
102272241  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102272271  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102272280  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102272298  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102272370  TP53; cellular tumor antigen p53 [KO:K04451]
102272421  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102272495  ANGPT2; angiopoietin-2 [KO:K05466]
102272535  EREG; proepiregulin isoform X1 [KO:K09784]
102272638  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102272711  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102272890  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
102272897  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
102272946  MAP4K2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102272962  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
102272974  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102272986  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102273045  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102273125  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102273253  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102273267  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102273425  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
102273440  PGF; placenta growth factor isoform X2 [KO:K16859]
102273447  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
102273668  FGF9; fibroblast growth factor 9 [KO:K04358]
102273820  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102273821  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
102273826  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102273898  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102273906  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102274050  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
102274075  MAP3K21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102274085  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
102274116  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102274152  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102274246  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102274299  FGF23; fibroblast growth factor 23 [KO:K22428]
102274304  MYC; LOW QUALITY PROTEIN: myc proto-oncogene protein [KO:K04377]
102274384  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102274400  INS; insulin [KO:K04526]
102274499  NRTN; neurturin [KO:K25414]
102274647  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102274689  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor 2 [KO:K13769]
102274702  FGF20; fibroblast growth factor 20 [KO:K04358]
102274804  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
102275053  FOS; protein c-Fos [KO:K04379]
102275116  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102275265  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
102275307  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102275520  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X20 [KO:K08018]
102275574  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102275841  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102275863  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102275883  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102276010  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
102276040  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102276116  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102276240  MRAS; ras-related protein M-Ras [KO:K07831]
102276438  MAP4K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
102276480  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
102276523  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102276588  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
102276738  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
102276849  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102276868  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102277011  HRAS; GTPase HRas isoform X1 [KO:K02833]
102277012  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102277019  [KO:K07836]
102277025  CRKL; crk-like protein [KO:K04438]
102277352  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102277585  SOS2; son of sevenless homolog 2 [KO:K03099]
102277590  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102277736  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102277837  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
102277911  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102277958  NTF4; neurotrophin-4 [KO:K12457]
102277976  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102277977  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
102278105  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102278237  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102278455  PSPN; persephin [KO:K25416]
102278516  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102278560  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
102278591  [KO:K02833]
102278631  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102278697  [KO:K03283]
102278724  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102278844  CRK; adapter molecule crk isoform X1 [KO:K04438]
102278856  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102278977  [KO:K03283]
102278998  CACNG1; voltage-dependent calcium channel gamma-1 subunit isoform X1 [KO:K04866]
102279034  FGF16; fibroblast growth factor 16 [KO:K04358]
102279268  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102279307  RRAS; ras-related protein R-Ras [KO:K07829]
102279617  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102279713  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102279714  BDNF; neurotrophic factor BDNF precursor form isoform X2 [KO:K04355]
102279944  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102279964  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102280279  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102280670  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102280941  VEGFC; vascular endothelial growth factor C [KO:K05449]
102281279  MAP3K12; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102281308  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102281443  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102281497  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
102281567  FLNA; filamin-A isoform X1 [KO:K04437]
102281578  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102281757  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102281886  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102281889  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102281905  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102281947  ANGPT4; angiopoietin-4 [KO:K05467]
102282019  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
102282265  FGF21; fibroblast growth factor 21 [KO:K22429]
102282330  IL1A; interleukin-1 alpha [KO:K04383]
102282456  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102282579  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102282587  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102282595  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102282598  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102282641  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102282862  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102282890  IL1B; interleukin-1 beta [KO:K04519]
102283049  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102283142  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102283195  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102283212  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102283357  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
102283364  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
102283491  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102283497  SRF; serum response factor [KO:K04378]
102283530  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102283542  [KO:K04381]
102283668  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102283685  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102283727  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102283891  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102283969  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
102284148  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102284170  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
102284187  KITLG; kit ligand isoform X1 [KO:K05461]
102284499  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
102284671  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
102284897  FGF2; fibroblast growth factor 2 [KO:K18497]
102284923  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102284956  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
102284968  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
102285079  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
102285226  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
102285317  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102285474  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102285544  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102285596  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102285629  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
102285634  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102285655  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
102285746  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102285848  MAPK12; LOW QUALITY PROTEIN: mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102285873  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102285891  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102285914  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102285944  HSPA1L; heat shock 70 kDa protein 1-like isoform X2 [KO:K03283]
102286083  FGF7; fibroblast growth factor 7 [KO:K04358]
102286114  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102286224  RAP1A; ras-related protein Rap-1A [KO:K04353]
102286241  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102286323  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
102286396  RELB; transcription factor RelB isoform X1 [KO:K09253]
102286500  KRAS; GTPase KRas isoform X1 [KO:K07827]
102286752  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102286805  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102286943  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102286969  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102286986  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102287207  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
102287270  FGF18; fibroblast growth factor 18 [KO:K04358]
102287278  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102287348  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102287352  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102287427  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102287477  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
102287518  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102287576  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102287719  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102287805  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102287968  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102288000  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102288007  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102288137  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
102288141  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 [KO:K04465]
102288216  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102288254  MAX; protein max isoform X1 [KO:K04453]
102288284  NF1; neurofibromin isoform X1 [KO:K08052]
102288339  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
106700998  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
106701244  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
138983909  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
138987258  ARTN; artemin isoform X1 [KO:K25415]
138988490  JUND; LOW QUALITY PROTEIN: transcription factor JunD [KO:K04449]
138991483  [KO:K07836]
138991725  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Gene 320:3-21 (2003)
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
bom04070  Phosphatidylinositol signaling system
bom04110  Cell cycle
bom04115  p53 signaling pathway
bom04210  Apoptosis
bom04310  Wnt signaling pathway
bom04668  TNF signaling pathway
KO pathway
ko04010   

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