KEGG   PATHWAY: bom04151
Entry
bom04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Bos mutus (wild yak)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
bom04151  PI3K-Akt signaling pathway
bom04151

Other DBs
GO: 0043491
Organism
Bos mutus (wild yak) [GN:bom]
Gene
102264327  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102264670  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102264680  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
102264869  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102264981  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102264992  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102265040  RELN; reelin [KO:K06249] [EC:3.4.21.-]
102265047  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
102265105  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102265298  EPOR; erythropoietin receptor isoform X3 [KO:K05079]
102265427  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102265554  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102265732  LAMC3; laminin subunit gamma-3 [KO:K06247]
102265778  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102265783  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102265930  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
102265941  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102265959  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102266065  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102266141  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
102266170  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102266290  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102266344  BRCA1; breast cancer type 1 susceptibility protein isoform X5 [KO:K10605] [EC:2.3.2.27]
102266354  [KO:K05414]
102266436  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102266466  [KO:K05414]
102266601  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102266636  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102266681  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
102266700  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102266712  ITGA3; integrin alpha-3 [KO:K06482]
102266736  LAMA5; laminin subunit alpha-5 [KO:K06240]
102266890  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102266922  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102267028  COMP; cartilage oligomeric matrix protein [KO:K04659]
102267130  ANGPT1; angiopoietin-1 [KO:K05465]
102267150  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
102267202  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102267219  [KO:K07208]
102267343  TSC2; tuberin isoform X1 [KO:K07207]
102267423  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102267511  [KO:K16197]
102267556  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
102267601  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102267762  [KO:K05414]
102267776  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102267813  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102267837  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102267874  EFNA1; ephrin-A1 [KO:K05462]
102267975  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102267985  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102268051  LAMC1; laminin subunit gamma-1 [KO:K05635]
102268077  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102268088  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102268113  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
102268154  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102268167  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
102268179  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102268311  GHR; growth hormone receptor isoform X1 [KO:K05080]
102268327  LAMC2; laminin subunit gamma-2 [KO:K06246]
102268417  RELA; transcription factor p65 [KO:K04735]
102268478  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102268583  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
102268592  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
102268660  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102268672  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102268693  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
102268794  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102268820  HSP90B1; endoplasmin [KO:K09487]
102268835  TLR2; toll-like receptor 2 [KO:K10159]
102268918  ITGB3; integrin beta-3 [KO:K06493]
102269089  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102269203  NRAS; GTPase NRas [KO:K07828]
102269208  [KO:K05439]
102269313  PRLR; prolactin receptor [KO:K05081]
102269424  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1 [KO:K16340] [EC:3.1.3.16]
102269650  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102269660  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102269710  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102269744  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102269800  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102269855  [KO:K04542]
102269868  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102270172  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
102270414  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102270539  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102270546  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102270607  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
102270608  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
102270743  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102270828  FGF19; fibroblast growth factor 19 [KO:K22603]
102270841  AREG; amphiregulin [KO:K09782]
102270926  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102270944  ITGB5; integrin beta-5 [KO:K06588]
102270981  [KO:K05414]
102271008  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102271065  THBS3; thrombospondin-3 [KO:K04659]
102271079  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102271113  FGF4; fibroblast growth factor 4 [KO:K04358]
102271219  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102271235  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
102271261  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
102271380  [KO:K04570]
102271394  FGF3; fibroblast growth factor 3 [KO:K04358]
102271403  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
102271420  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
102271428  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
102271434  [KO:K05439]
102271535  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
102271554  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
102271562  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102271607  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
102271710  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
102271714  [KO:K05439]
102271756  PCK1; LOW QUALITY PROTEIN: phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
102271788  [KO:K05438]
102271854  OSM; oncostatin-M [KO:K05418]
102271993  FGF10; fibroblast growth factor 10 [KO:K04358]
102271999  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102272003  [KO:K05439]
102272008  FGF6; fibroblast growth factor 6 [KO:K04358]
102272009  IGF1; insulin-like growth factor 1 isoform X3 [KO:K05459]
102272039  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
102272045  IL4; interleukin-4 [KO:K05430]
102272072  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
102272113  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102272188  CSF3; granulocyte colony-stimulating factor [KO:K05423]
102272209  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102272280  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102272347  F2R; proteinase-activated receptor 1 [KO:K03914]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102272370  TP53; cellular tumor antigen p53 [KO:K04451]
102272379  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102272426  IL2; interleukin-2 [KO:K05429]
102272495  ANGPT2; angiopoietin-2 [KO:K05466]
102272535  EREG; proepiregulin isoform X1 [KO:K09784]
102272576  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102272842  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102272943  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
102272986  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102273003  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
102273019  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102273105  ITGA8; integrin alpha-8 [KO:K06584]
102273253  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102273267  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102273425  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
102273440  PGF; placenta growth factor isoform X2 [KO:K16859]
102273578  [KO:K16197]
102273668  FGF9; fibroblast growth factor 9 [KO:K04358]
102273730  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102273764  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
102273820  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102273972  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
102274299  FGF23; fibroblast growth factor 23 [KO:K22428]
102274304  MYC; LOW QUALITY PROTEIN: myc proto-oncogene protein [KO:K04377]
102274384  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102274400  INS; insulin [KO:K04526]
102274461  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102274499  NRTN; neurturin [KO:K25414]
102274553  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102274562  [KO:K05439]
102274580  SPP1; osteopontin [KO:K06250]
102274689  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor 2 [KO:K13769]
102274702  FGF20; fibroblast growth factor 20 [KO:K04358]
102274858  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102274942  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102274964  LAMB3; laminin subunit beta-3 [KO:K06244]
102275031  [KO:K05439]
102275204  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102275213  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102275218  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102275260  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102275376  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
102275472  VTN; vitronectin [KO:K06251]
102275509  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
102275522  IBSP; integrin-binding sialoprotein [KO:K06253]
102275560  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102275603  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102275760  IL3; interleukin-3 [KO:K04736]
102275793  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102275813  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
102275883  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102275926  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102275975  BAD; bcl2-associated agonist of cell death [KO:K02158]
102276010  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
102276040  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102276125  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
102276156  BCL2L11; LOW QUALITY PROTEIN: bcl-2-like protein 11 [KO:K16341]
102276200  ITGA5; integrin alpha-5 [KO:K06484]
102276245  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102276588  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
102276877  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102277011  HRAS; GTPase HRas isoform X1 [KO:K02833]
102277130  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102277321  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102277344  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
102277355  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102277419  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
102277548  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102277585  SOS2; son of sevenless homolog 2 [KO:K03099]
102277658  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
102277729  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
102277745  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
102277811  ITGA4; integrin alpha-4 [KO:K06483]
102277938  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102277958  NTF4; neurotrophin-4 [KO:K12457]
102278065  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102278105  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102278109  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
102278118  LAMB2; laminin subunit beta-2 [KO:K06243]
102278265  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102278368  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102278455  PSPN; persephin [KO:K25416]
102278458  COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
102278503  LAMB1; laminin subunit beta-1 [KO:K05636]
102278515  CD19; LOW QUALITY PROTEIN: B-lymphocyte antigen CD19 [KO:K06465]
102278533  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
102278545  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102278567  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
102278583  [KO:K03456]
102278591  [KO:K02833]
102278692  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102278724  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102278820  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
102278832  YWHAQ; 14-3-3 protein theta [KO:K16197]
102278863  STK11; serine/threonine-protein kinase STK11 isoform X4 [KO:K07298] [EC:2.7.11.1]
102278866  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
102278988  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
102279034  FGF16; fibroblast growth factor 16 [KO:K04358]
102279156  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
102279271  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
102279468  MTCP1; protein p13 MTCP-1 [KO:K16837]
102279608  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X3 [KO:K21290]
102279658  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
102279686  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102279714  BDNF; neurotrophic factor BDNF precursor form isoform X2 [KO:K04355]
102279821  EPO; erythropoietin [KO:K05437]
102279846  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
102279964  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102280095  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
102280180  FN1; fibronectin isoform X1 [KO:K05717]
102280257  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
102280296  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102280323  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102280497  [KO:K05415]
102280670  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102280709  TSC1; hamartin isoform X1 [KO:K07206]
102280934  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
102280941  VEGFC; vascular endothelial growth factor C [KO:K05449]
102281065  [KO:K05415]
102281111  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
102281308  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102281399  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
102281443  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102281505  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102281573  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
102281665  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X3 [KO:K07825]
102281727  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102281756  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102281886  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102281889  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102281947  ANGPT4; angiopoietin-4 [KO:K05467]
102281967  ITGA1; integrin alpha-1 [KO:K06480]
102281976  YWHAG; 14-3-3 protein gamma [KO:K16198]
102282136  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
102282139  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102282217  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
102282265  FGF21; fibroblast growth factor 21 [KO:K22429]
102282456  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102282466  [KO:K05415]
102282491  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102282540  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102282596  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
102282598  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102282731  VWF; von Willebrand factor [KO:K03900]
102282767  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102282841  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102283049  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102283195  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102283212  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102283263  ITGB8; integrin beta-8 [KO:K06591]
102283384  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
102283468  [KO:K06238]
102283502  TNC; tenascin isoform X4 [KO:K06252]
102283808  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
102283891  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102283906  TNR; tenascin-R isoform X1 [KO:K06252]
102284180  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102284187  KITLG; kit ligand isoform X1 [KO:K05461]
102284581  [KO:K05415]
102284624  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14 [KO:K05631]
102284629  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
102284639  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102284664  IRS1; insulin receptor substrate 1 [KO:K16172]
102284697  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
102284714  THBS4; thrombospondin-4 [KO:K04659]
102284897  FGF2; fibroblast growth factor 2 [KO:K18497]
102284923  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102285183  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
102285223  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
102285317  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102285344  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102285390  RPTOR; regulatory-associated protein of mTOR isoform X2 [KO:K07204]
102285417  [KO:K05414]
102285426  ITGA11; integrin alpha-11 [KO:K06587]
102285452  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
102285459  [KO:K05414]
102285482  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102285634  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102285710  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102285753  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102285810  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102285914  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102286011  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102286083  FGF7; fibroblast growth factor 7 [KO:K04358]
102286137  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102286241  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102286395  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
102286500  KRAS; GTPase KRas isoform X1 [KO:K07827]
102286624  CHAD; chondroadherin [KO:K06248]
102286767  IL7; interleukin-7 isoform X1 [KO:K05431]
102286868  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102286943  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102286969  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102287014  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
102287019  TNN; tenascin-N [KO:K06252]
102287154  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
102287197  YWHAH; 14-3-3 protein eta [KO:K16198]
102287216  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
102287270  FGF18; fibroblast growth factor 18 [KO:K04358]
102287332  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102287352  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102287363  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
102287427  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102287439  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102287455  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102287477  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
102287482  PPP2R2D; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
102287490  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
102287555  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
102287565  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102287620  LAMA2; laminin subunit alpha-2 [KO:K05637]
102287801  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102287919  IL6; interleukin-6 [KO:K05405]
102287925  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
102287968  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102288004  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102288007  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102288141  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 [KO:K04465]
102288145  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102288174  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
102288212  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X4 [KO:K09049]
102288216  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102288240  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102288249  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
106701100  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
106701364  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106701660  [KO:K05439]
138987258  ARTN; artemin isoform X1 [KO:K25415]
138988994  [KO:K05414]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
bom00010  Glycolysis / Gluconeogenesis
bom04010  MAPK signaling pathway
bom04012  ErbB signaling pathway
bom04062  Chemokine signaling pathway
bom04064  NF-kappa B signaling pathway
bom04068  FoxO signaling pathway
bom04110  Cell cycle
bom04115  p53 signaling pathway
bom04150  mTOR signaling pathway
bom04210  Apoptosis
bom04370  VEGF signaling pathway
bom04510  Focal adhesion
bom04620  Toll-like receptor signaling pathway
bom04630  JAK-STAT signaling pathway
bom04662  B cell receptor signaling pathway
bom04910  Insulin signaling pathway
KO pathway
ko04151   

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