KEGG   PATHWAY: bta04640
Entry
bta04640                    Pathway                                
Name
Hematopoietic cell lineage - Bos taurus (cow)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
bta04640  Hematopoietic cell lineage
bta04640

Organism
Bos taurus (cow) [GN:bta]
Gene
281885  KITLG; kit ligand precursor [KO:K05461]
280827  IL7; interleukin-7 precursor [KO:K05431]
280824  IL4; interleukin-4 precursor [KO:K05430]
281095  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
282233  FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
280825  IL5; interleukin-5 precursor [KO:K05428]
281096  CSF3; granulocyte colony-stimulating factor precursor [KO:K05423]
280823  IL3; interleukin-3 precursor [KO:K04736]
280826  IL6; interleukin-6 precursor [KO:K05405]
100337295  IL11; interleukin-11 [KO:K05417]
281250  IL1A; interleukin-1 alpha precursor [KO:K04383]
281251  IL1B; interleukin-1 beta precursor [KO:K04519]
280943  TNF; tumor necrosis factor [KO:K03156]
281094  CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
280784  EPO; erythropoietin precursor [KO:K05437]
538672  THPO; thrombopoietin precursor [KO:K06854]
281051  CD34; hematopoietic progenitor cell antigen CD34 precursor [KO:K06474]
512700  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
281120  DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
282490  BOLA-DMA; HLA class II histocompatibility antigen, DM alpha chain precursor [KO:K06752]
282491  BOLA-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
282493  BOLA-DOB; HLA class II histocompatibility antigen, DO beta chain precursor [KO:K06752]
282494  BOLA-DQA5; major histocompatibility complex, class II, DQ alpha 5 precursor [KO:K06752]
282495  BOLA-DQB; major histocompatibility complex, class II, DQ beta precursor [KO:K06752]
282498  BOLA-DYB; major histocompatibility complex, class II, DY beta precursor [KO:K06752]
282535  BOLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
282530  BOLA-DRB3; major histocompatibility complex, class II, DRB3 [KO:K06752]
525727  BOLA-DOA; HLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
506214  BOLA-DRA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752]
539241  BLA-DQB; boLa class II histocompatibility antigen, DQB*0101 beta chain precursor [KO:K06752]
100848815  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like precursor [KO:K06752]
282497  BOLA-DYA; major histocompatibility complex, class II, DY alpha precursor [KO:K06752]
618722  DSB; MHC class II antigen DS beta [KO:K06752]
538700  BOLA-DRB2; HLA class II histocompatibility antigen, DR beta 5 chain isoform X3 [KO:K06752]
281057  CD44; CD44 antigen precursor [KO:K06256]
280832  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
281861  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
521554  IL7R; interleukin-7 receptor subunit alpha precursor [KO:K05072]
504698  TFRC; transferrin receptor protein 1 [KO:K06503]
327677  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
510073  CD7; T-cell antigen CD7 precursor [KO:K06457]
497022  CD2; T-cell surface antigen CD2 precursor [KO:K06449]
280745  CD5; T-cell surface glycoprotein CD5 precursor [KO:K06455]
509004  CD1B; CD1b molecule precursor [KO:K06448]
509005  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1b-2 [KO:K06448]
510832  CD1E; T-cell surface glycoprotein CD1e, membrane-associated precursor [KO:K06448]
515418  T-cell surface glycoprotein CD1a precursor [KO:K06448]
521663  CD1B5; CD1b molecule-like precursor [KO:K06448]
781011  CD1A; T-cell surface glycoprotein CD1a isoform 1 precursor [KO:K06448]
781726  T-cell surface glycoprotein CD1b-2 isoform X2 [KO:K06448]
782367  antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
788175  antigen-presenting glycoprotein CD1d [KO:K06448]
507767  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1b-1-like [KO:K06448]
516046  CD1D; CD1D antigen, d polypeptide [KO:K06448]
512286  antigen-presenting glycoprotein CD1d [KO:K06448]
407098  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
281060  CD8A; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
508633  CD8B; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459]
281053  CD3D; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
281054  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
281055  CD3G; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
536741  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
280746  CD9; CD9 antigen [KO:K06460]
517359  CD19; B-lymphocyte antigen CD19 precursor [KO:K06465]
514582  CD22; B-cell receptor CD22 isoform X2 [KO:K06467]
767920  CD24; signal transducer CD24 [KO:K06469]
505653  MS4A1; B-lymphocyte antigen CD20 [KO:K06466]
407126  CR2; complement receptor type 2 precursor [KO:K04012]
508751  CD37; leukocyte antigen CD37 [KO:K06475]
524810  IgM precursor [KO:K06856]
100300716  immunoglobulin heavy variable 4-38-2 [KO:K06856]
100300806  immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]
104968484  immunoglobulin heavy variable 4-59 [KO:K06856]
407106  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X4 [KO:K06468]
100138386  CR1L; LOW QUALITY PROTEIN: complement component receptor 1-like protein [KO:K04011]
100336606  CSF2RA; uncharacterized protein CSF2RA isoform X1 [KO:K05066]
100299249  IL3RA; interleukin-3 receptor subunit alpha isoform X3 [KO:K04737]
132342083  interleukin-3 receptor subunit alpha-like isoform X1 [KO:K04737]
508441  myeloid cell surface antigen CD33 isoform X3 [KO:K06473]
100138951  CD33 antigen-like precursor [KO:K06473]
404154  IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071]
507359  IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055]
282227  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
509418  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
404191  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
407124  ITGAM; integrin alpha-M precursor [KO:K06461]
281048  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
618294  IL9R; interleukin-9 receptor isoform X3 [KO:K05073]
515640  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
515700  IL1R2; interleukin-1 receptor type 2 precursor [KO:K04387]
132344945  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
615848  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
281144  EPOR; erythropoietin receptor precursor [KO:K05079]
281052  CD36; platelet glycoprotein 4 [KO:K06259]
518526  platelet glycoprotein 4 [KO:K06259]
617836  GYPA; glycophorin-A precursor [KO:K06575]
518609  CD55; complement decay-accelerating factor [KO:K04006]
505574  CD59; CD59 glycoprotein precursor [KO:K04008]
508932  IL11RA; interleukin-11 receptor subunit alpha precursor [KO:K05056]
282642  ITGB3; integrin beta-3 precursor [KO:K06493]
515011  ITGA2B; integrin alpha-IIb [KO:K06476]
617668  GP9; platelet glycoprotein IX [KO:K06263]
504977  GP1BA; LOW QUALITY PROTEIN: platelet glycoprotein Ib alpha chain [KO:K06261]
522692  GP5; platelet glycoprotein V [KO:K06260]
535951  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
281872  ITGA2; integrin alpha-2 precursor [KO:K06481]
508490  ITGA3; integrin alpha-3 precursor [KO:K06482]
282882  ITGA4; integrin alpha-4 precursor [KO:K06483]
281873  ITGA5; integrin alpha-5 [KO:K06484]
535043  ITGA6; integrin alpha-6 precursor [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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