KEGG   PATHWAY: cgib04261
Entry
cgib04261                   Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Carassius gibelio (silver crucian carp)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
cgib04261  Adrenergic signaling in cardiomyocytes
cgib04261

Other DBs
GO: 0001997
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127969102  beta-1 adrenergic receptor [KO:K04141]
128025364  beta-1 adrenergic receptor-like [KO:K04141]
127971864  beta-2 adrenergic receptor-like [KO:K04142]
127971865  beta-2 adrenergic receptor-like [KO:K04142]
127985972  adrenoceptor beta 2, surface b [KO:K04142]
128027182  beta-2 adrenergic receptor-like [KO:K04142]
127959119  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
128015937  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
127983864  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
127938175  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
127938196  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
127950468  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
128022044  adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
127979001  adenylate cyclase type 2b [KO:K08042] [EC:4.6.1.1]
127974531  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
127935848  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
127974391  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
127938084  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
128031089  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
127984289  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
127964859  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
128020010  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
127944560  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
127944783  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
128011259  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
128011825  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
127961582  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
128016846  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
127983755  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
127934466  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
127938090  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
127950475  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
128031463  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
127943078  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
127953286  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
127955411  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
127988423  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
127974862  blood vessel epicardial substance isoform X1 [KO:K21108]
127965587  popeye domain-containing 2 isoform X1 [KO:K26206]
127974863  popeye domain-containing protein 3 [KO:K26207]
127984077  potassium channel subfamily K member 2b [KO:K04913]
127933482  potassium channel subfamily K member 2-like [KO:K04913]
127975909  potassium channel subfamily K member 2 [KO:K04913]
127951130  protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
127952862  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
127953664  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
127967775  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
127948750  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
128022625  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
128024411  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
128017857  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
127979328  sodium/potassium-transporting ATPase subunit alpha-3a [KO:K01539] [EC:7.2.2.13]
127974388  sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
127934746  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
127935626  sodium/potassium-transporting ATPase subunit alpha-3-like [KO:K01539] [EC:7.2.2.13]
127948930  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
127948931  sodium/potassium-transporting ATPase subunit alpha-1-like isoform X1 [KO:K01539] [EC:7.2.2.13]
127948932  sodium/potassium-transporting ATPase subunit alpha-1-like isoform X1 [KO:K01539] [EC:7.2.2.13]
127950903  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
128030739  sodium/potassium-transporting ATPase subunit alpha-3-like [KO:K01539] [EC:7.2.2.13]
128012821  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
128019995  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
128012895  sodium/potassium-transporting ATPase subunit alpha-1a.4 [KO:K01539] [EC:7.2.2.13]
127979057  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
127971977  protein ATP1B4 isoform X1 [KO:K01540]
127944898  sodium/potassium-transporting ATPase subunit beta-2-like isoform X1 [KO:K01540]
127972886  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
127958740  sodium/potassium-transporting ATPase subunit beta-2-like isoform X1 [KO:K01540]
127949216  sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
127959786  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
127950526  sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
128015589  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
128026987  sodium/potassium-transporting ATPase subunit beta-3-like isoform X1 [KO:K01540]
128027206  protein ATP1B4-like isoform X1 [KO:K01540]
128003574  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
128011484  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
128028728  sodium/potassium-transporting ATPase subunit beta-3b [KO:K01540]
127957936  sodium/potassium-transporting ATPase subunit gamma-like [KO:K01538]
127987958  sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
127974998  sodium/hydrogen exchanger 1-like [KO:K05742]
127935208  sodium/hydrogen exchanger 1b [KO:K05742]
128030322  sodium/hydrogen exchanger 1-like [KO:K05742]
127961897  uncharacterized protein LOC127961897 [KO:K04926]
128014027  potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
128016619  potassium voltage-gated channel subfamily KQT member 1-like isoform X1 [KO:K04926]
127963569  plasma membrane calcium-transporting ATPase 3a isoform X1 [KO:K05850] [EC:7.2.2.10]
127944638  plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
127956857  plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
127975219  plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
127947371  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
127968058  plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
127968658  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
128014481  plasma membrane calcium-transporting ATPase 1b [KO:K05850] [EC:7.2.2.10]
128022362  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
128011320  plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
128018873  plasma membrane calcium-transporting ATPase 3-like isoform X1 [KO:K05850] [EC:7.2.2.10]
127961711  solute carrier family 8 member 4b [KO:K05849]
127970774  sodium/calcium exchanger 3 isoform X1 [KO:K05849]
127942370  solute carrier family 8 member 4a [KO:K05849]
127933261  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
127972942  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
127957754  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
127967808  sodium/calcium exchanger 1a isoform X1 [KO:K05849]
127976295  sodium/calcium exchanger 1b isoform X1 [KO:K05849]
128022208  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
128026031  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
128004872  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
128029520  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
127951544  sodium channel, voltage gated, type XII, alpha a [KO:K04838]
127946327  sodium channel protein type 2 subunit alpha-like isoform X1 [KO:K04838]
128013502  sodium channel, voltage gated, type V-like, alpha b isoform X1 [KO:K04838]
127975507  sodium channel subunit beta-1-like [KO:K04845]
127935124  sodium channel, voltage-gated, type I, beta b [KO:K04845]
127978632  sodium channel subunit beta-1-like [KO:K04845]
128030427  sodium channel, voltage-gated, type I, beta a isoform X1 [KO:K04845]
128030428  si:ch211-225p5.8; sodium channel subunit beta-1 [KO:K04845]
127972621  sodium channel, voltage-gated, type IV, beta a [KO:K04848]
127958898  sodium channel subunit beta-4-like [KO:K04848]
128004050  sodium channel, voltage-gated, type IV, beta b [KO:K04848]
128028797  sodium channel subunit beta-4-like isoform X1 [KO:K04848]
127956189  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
127973732  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
127963129  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
127968377  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
128022121  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
127964170  calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
128018341  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
128018705  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
127963663  calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
127987679  calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
128018620  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
127953709  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
127947776  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
127961472  voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
128016436  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
127944565  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
127944786  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
128011118  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
128011305  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
127964447  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
127960198  voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
128015412  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
128020013  voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
127974291  voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
127956800  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
127934749  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
127977265  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
127942915  voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
127959340  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
128015996  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
127963142  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
127968378  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
128022123  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
127956880  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
127947311  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
127951872  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
127960078  calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
127940822  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
128015466  voltage-dependent calcium channel gamma-1 subunit-like isoform X1 [KO:K04866]
127951861  calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
127948971  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
127959422  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
128015303  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
127952906  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
127949345  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
127950910  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
127985664  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
127951825  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
127960076  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
127940731  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
127944433  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
127953426  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
127960077  calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
128015460  voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
127975235  voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
127934987  calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
127978774  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
128030773  voltage-dependent calcium channel gamma-6 subunit-like isoform X1 [KO:K04871]
127974515  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
127935046  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
127978718  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
128030171  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
127975547  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
127935042  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
127978724  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
128030775  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04873]
127962064  calmodulin-like protein 4a [KO:K02183]
127942142  calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
127984211  calmodulin-1b [KO:K02183]
127972837  calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
127933454  calmodulin-1 [KO:K02183]
127976239  calmodulin-1a [KO:K02183]
127938373  calmodulin-1 [KO:K02183]
127969054  calmodulin-1 [KO:K02183]
127970186  calmodulin-1 [KO:K02183]
128013890  calmodulin-like protein 4 [KO:K02183]
127985494  calmodulin-1 [KO:K02183]
128025263  calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
128016312  calmodulin-like protein 4 [KO:K02183]
128026459  calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
128028785  calmodulin-alpha isoform X1 [KO:K02183]
127942234  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127972945  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127966071  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
127968924  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127961197  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127969939  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
128025447  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127986448  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
128016599  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
128026274  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
128012275  calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
128020784  calcium/calmodulin-dependent protein kinase type II subunit delta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127976444  ryanodine receptor 2 [KO:K04962]
128025589  ryanodine receptor 2 isoform X1 [KO:K04962]
127941767  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
127971951  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
127965984  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
128021558  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
127986230  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
128027577  protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
127958614  protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
127994569  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
127942027  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
127971312  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
127971797  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
127963762  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
127972775  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
127966343  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
127948691  protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
127968986  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
128021333  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
127985682  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
128025486  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
128027623  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
128027799  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
128018996  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
127965011  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like isoform X1 [KO:K11583]
127950944  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
128031753  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
128029010  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like [KO:K11583]
128019974  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like isoform X1 [KO:K11583]
127983606  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
127983919  protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
127984003  protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
127933169  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
127938421  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
127938541  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
127938897  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
127961158  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
127969894  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
127970284  protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
128026000  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
128017098  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
128026494  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
127962352  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
127953668  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
127933422  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127966576  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
127958453  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B [KO:K06269] [EC:3.1.3.16]
127976372  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127949238  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
128014916  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like [KO:K06269] [EC:3.1.3.16]
128024914  protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
128017591  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127944441  troponin C, slow skeletal and cardiac muscles [KO:K05865]
128011574  troponin C type 1b (slow) [KO:K05865]
127944184  troponin T, cardiac muscle isoforms-like [KO:K12045]
127956147  troponin T, cardiac muscle isoforms-like [KO:K12045]
127956452  troponin T, slow skeletal muscle-like isoform X1 [KO:K12045]
127947474  LOW QUALITY PROTEIN: troponin T, cardiac muscle isoforms-like [KO:K12045]
127976166  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
127960008  troponin T, cardiac muscle isoforms [KO:K12045]
127977653  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
128014052  troponin T2d, cardiac [KO:K12045]
128016014  troponin T, cardiac muscle isoforms-like [KO:K12045]
128011979  troponin T, cardiac muscle isoforms-like [KO:K12045]
127961807  tropomyosin alpha-1 chain-like [KO:K10373]
127978924  tropomyosin alpha-3 chain isoform X1 [KO:K10373]
127935180  tropomyosin alpha-3 chain-like isoform X1 [KO:K10373]
127947331  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
128014098  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
128016989  tropomyosin alpha-1 chain [KO:K10373]
127966368  tropomyosin beta chain isoform X1 [KO:K10374]
128021429  tropomyosin beta chain-like isoform X1 [KO:K10374]
127942743  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
127938098  tropomyosin 4b isoform X1 [KO:K10375]
127951105  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
127987911  tropomyosin 4a isoform X1 [KO:K10375]
127970770  actin alpha 1, skeletal muscle b [KO:K12314]
127983981  actin, alpha, cardiac muscle 2 [KO:K12314]
127984180  actin, alpha cardiac muscle 1a [KO:K12314]
127933287  actin, alpha cardiac muscle 1b [KO:K12314]
127947436  actin, alpha cardiac muscle 1-like [KO:K12314]
127949120  actin, alpha skeletal muscle 2-like [KO:K12314]
127976778  actin, alpha skeletal muscle [KO:K12314]
127938823  actin, alpha cardiac muscle 1 [KO:K12314]
127938914  actin, alpha cardiac muscle [KO:K12314]
128014725  beta-actin-like protein 2 [KO:K12314]
128026230  actin, alpha skeletal muscle 2-like [KO:K12314]
128020021  actin, alpha skeletal muscle 2 [KO:K12314]
127938477  myosin-6 [KO:K17751]
127950773  myosin-7-like [KO:K17751]
127950774  myosin-7 [KO:K17751]
128028498  myosin-7-like isoform X1 [KO:K17751]
128028524  myosin-7-like [KO:K17751]
128012824  slow myosin heavy chain 1 [KO:K17751]
127963050  myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
127957130  myosin regulatory light chain 2a [KO:K10351]
128019022  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
127942857  myosin light chain 4 [KO:K12750]
127957160  cardiac myosin light chain-1 [KO:K12750]
127957162  myosin light chain 4-like [KO:K12750]
127969344  myosin light chain 3, skeletal muscle isoform-like [KO:K12750]
128025035  myosin light chain 4-like isoform X1 [KO:K12750]
127988805  myosin light chain 4-like [KO:K12750]
127989724  myosin light chain 4-like [KO:K12750]
127933416  cardiac phospholamban-like [KO:K05852]
127976170  cardiac phospholamban-like [KO:K05852]
127938410  cardiac phospholamban-like [KO:K05852]
127941595  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
127952356  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
127963602  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
127957211  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
127948414  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
127949384  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
128024912  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
127985745  sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
128017069  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
128007784  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
128018909  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
127970357  angiotensinogen-like [KO:K09821]
128026239  serpin A3-1-like [KO:K09821]
127945824  type-1 angiotensin II receptor A-like [KO:K04166]
127950581  type-1 angiotensin II receptor B [KO:K04166]
128028883  type-1 angiotensin II receptor-like [KO:K04166]
128013037  type-1 angiotensin II receptor A [KO:K04166]
127957540  type-2 angiotensin II receptor [KO:K04167]
128011687  type-2 angiotensin II receptor-like [KO:K04167]
127964033  alpha-1A adrenergic receptor-like [KO:K04135]
127966344  alpha-1A adrenergic receptor [KO:K04135]
128021674  alpha-1A adrenergic receptor-like [KO:K04135]
128018993  adrenoceptor alpha 1Aa [KO:K04135]
127941529  alpha-1A adrenergic receptor-like [KO:K04136]
127971449  adrenoceptor alpha 1Bb [KO:K04136]
127986557  alpha-1A adrenergic receptor [KO:K04136]
128027494  alpha-1A adrenergic receptor-like [KO:K04136]
127949252  alpha-1D adrenergic receptor-like [KO:K04137]
128017398  alpha-1D adrenergic receptor-like [KO:K04137]
127943103  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
127957746  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
127993703  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
127983494  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
127975794  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
127976340  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
127976341  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127976952  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
127938266  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127938267  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
127961413  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
128031331  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like isoform X1 [KO:K05858] [EC:3.1.4.11]
128031818  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
127944331  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
127953362  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
127959456  protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
128015459  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
127952654  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
127957801  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
127948455  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
128013953  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127933346  ribosomal protein S6 kinase alpha-5-like isoform X1 [KO:K04445] [EC:2.7.11.1]
127976337  ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
127965540  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
127948728  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
127949322  cyclic AMP-responsive element-binding protein 1a [KO:K05870]
128015946  cyclic AMP-responsive element-binding protein 1-like isoform X1 [KO:K05870]
128019847  cyclic AMP-responsive element-binding protein 1 [KO:K05870]
127965330  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
128019591  cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]
127953568  activating transcription factor 4b [KO:K04374]
127946235  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
127959420  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
128015302  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
127942500  cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
127962682  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
127963943  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
127956618  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
127937701  cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
127950428  cyclic AMP-responsive element-binding protein 3-like protein 3-A isoform X1 [KO:K09048]
127978518  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
128016808  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
127987842  cyclic AMP-responsive element-binding protein 3-like protein 3-A isoform X1 [KO:K09048]
128018511  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
128030265  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
127974585  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
127934923  cyclic AMP-responsive element-binding protein 5-like [KO:K09047]
127978585  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
128030994  cyclic AMP-responsive element-binding protein 5-like isoform X1 [KO:K09047]
127979193  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
127934886  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
127951116  cAMP-responsive element modulator isoform X1 [KO:K09052]
127934620  cAMP-responsive element modulator-like isoform X1 [KO:K09052]
128013162  cAMP responsive element modulator b [KO:K09052]
127946353  apoptosis regulator Bcl-2-like [KO:K02161]
127950859  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
128025189  apoptosis regulator Bcl-2 [KO:K02161]
128013154  apoptosis regulator Bcl-2-like [KO:K02161]
127945124  rap guanine nucleotide exchange factor 3-like [KO:K08014]
128011334  rap guanine nucleotide exchange factor 3-like isoform X1 [KO:K08014]
127965430  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
127960269  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
128015343  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
128019598  rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
127963306  mitogen-activated protein kinase 13-like isoform X1 [KO:K04441] [EC:2.7.11.24]
127963308  mitogen-activated protein kinase 13-like isoform X1 [KO:K04441] [EC:2.7.11.24]
127963612  mitogen-activated protein kinase 13-like isoform X1 [KO:K04441] [EC:2.7.11.24]
127944337  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
127963713  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
127956834  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
127934697  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
127968271  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
127977806  mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
127977816  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127939204  mitogen-activated protein kinase 14B-like isoform X1 [KO:K04441] [EC:2.7.11.24]
127977875  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128022597  mitogen-activated protein kinase 14B-like isoform X1 [KO:K04441] [EC:2.7.11.24]
128018668  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
128011117  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
128018929  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
127964082  guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
127956482  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
127973019  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
127947216  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
127967826  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
127959201  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
128014314  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
128022163  guanine nucleotide-binding protein G(i) subunit alpha-2-like isoform X1 [KO:K04630]
128015985  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
128018643  guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630]
127944295  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
127956869  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
127978781  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
127951860  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
127945127  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
127959275  phosphoinositide 3-kinase regulatory subunit 5-like isoform X1 [KO:K21290]
127959276  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
128015506  phosphoinositide 3-kinase regulatory subunit 5-like isoform X1 [KO:K21290]
128015507  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
127983655  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127933301  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127965879  v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
127934477  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127976560  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127949632  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127977516  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127941373  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127969870  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
128026318  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
128020093  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
cgib04020  Calcium signaling pathway
cgib04260  Cardiac muscle contraction
KO pathway
ko04261   
LinkDB

DBGET integrated database retrieval system