KEGG   PATHWAY: chx04914
Entry
chx04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Capra hircus (goat)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
chx04914  Progesterone-mediated oocyte maturation
chx04914

Other DBs
GO: 0001556
Organism
Capra hircus (goat) [GN:chx]
Gene
102175599  PGR; progesterone receptor [KO:K08556]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860765  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102185804  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108635583  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102180724  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
102171922  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102169019  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102185469  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102189798  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102169557  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102185858  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102184919  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102188104  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102173379  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102168790  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102171259  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
102168388  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
102169571  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
102173255  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
102176273  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X4 [KO:K02602]
102170057  SPDYA; speedy protein A isoform X2 [KO:K08694]
102171578  SPDYC; speedy protein C [KO:K08694]
102175356  speedy protein E4-like [KO:K08694]
100860751  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100861361  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102176051  CCNA1; cyclin-A1 [KO:K06627]
102190390  CCNA2; cyclin-A2 [KO:K06627]
102187061  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
100860851  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100861006  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102184607  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
108634353  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102179926  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102174475  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102191283  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102176487  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
102187875  G2/mitotic-specific cyclin-B1 [KO:K05868]
102188170  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
102179856  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
102186469  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
102179238  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
102171678  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
102181731  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
102179213  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
102187214  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
108634241  INS; insulin [KO:K04526]
100860838  IGF1; insulin-like growth factor I precursor [KO:K05459]
100861165  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102190893  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X2 [KO:K13296] [EC:3.1.4.17]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102169370  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102174360  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102172729  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
102170846  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
102191505  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
102183442  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
102178264  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
102170324  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
102181216  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
102170548  CDC27; cell division cycle protein 27 homolog isoform X5 [KO:K03350]
102183223  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
102172567  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
102178285  CDC16; cell division cycle protein 16 homolog [KO:K03353]
102175608  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
102186684  CDC23; cell division cycle protein 23 homolog [KO:K03355]
102177553  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
102169049  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
102170786  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
102170094  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102172283  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
102175744  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
102191666  KIF22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
chx04010  MAPK signaling pathway
chx04110  Cell cycle
KO pathway
ko04914   
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